FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217102359> ?p ?o ?g. }

• W3217102359 endingPage "5677" @default.
• W3217102359 startingPage "5666" @default.
• W3217102359 abstract "Systemic lupus erythematosus (SLE) causes damaging inflammation in multiple organs via the accumulation of immune complexes. These complexes activate plasmacytoid dendritic cells (pDCs) via toll-like receptors (TLRs), contributing to disease pathogenesis by driving the secretion of inflammatory type I interferons (IFNs). Antimalarial drugs, such as chloroquine (CQ), are TLR antagonists used to alleviate inflammation in SLE. However, they require ∼3 months of continuous use before achieving therapeutic efficacy and can accumulate in the retinal pigment epithelium with chronic use, resulting in retinopathy. We hypothesized that poly(ethylene glycol)-b-poly(propylene sulfide) filamentous nanocarriers, filomicelles (FMs), could directly deliver CQ to pDCs via passive, morphology-based targeting to concentrate drug delivery to specific immune cells, improve drug activity by increased inhibition of type I IFN, and enhance efficacy per dose. Healthy human peripheral blood mononuclear cells were treated with soluble CQ or CQ-loaded FMs, stimulated with TLR agonists or SLE patient sera, and type I IFN secretion was quantified via multi-subtype IFN-α ELISA and MX1 gene expression using real-time reverse transcription-quantitative polymerase chain reaction. Our results showed that 50 μg CQ/mg FM decreased MX1 expression and IFN-α production after TLR activation with either synthetic nucleic acid agonists or immune complex-rich sera from SLE patients. Cellular uptake and biodistribution studies showed that FMs preferentially accumulate in human pDCs and monocytes in vitro and in tissues frequently damaged in SLE patients (i.e., kidneys), while sparing the eye in vivo. These results showed that nanocarrier morphology enables drug delivery, and CQ-FMs may be equally effective and more targeted than soluble CQ at inhibiting SLE-relevant pathways." @default.
• W3217102359 created "2021-12-06" @default.
• W3217102359 creator A5001884475 @default.
• W3217102359 creator A5013361011 @default.
• W3217102359 creator A5023962863 @default.
• W3217102359 creator A5035108532 @default.
• W3217102359 creator A5037038581 @default.
• W3217102359 creator A5058829916 @default.
• W3217102359 creator A5063157829 @default.
• W3217102359 creator A5082433711 @default.
• W3217102359 creator A5088029154 @default.
• W3217102359 date "2021-11-23" @default.
• W3217102359 modified "2023-10-15" @default.
• W3217102359 title "Targeted Delivery of Chloroquine to Antigen-Presenting Cells Enhances Inhibition of the Type I Interferon Response" @default.
• W3217102359 cites W1540878706 @default.
• W3217102359 cites W1547552531 @default.
• W3217102359 cites W1636022800 @default.
• W3217102359 cites W1652582743 @default.
• W3217102359 cites W1959724402 @default.
• W3217102359 cites W1969072247 @default.
• W3217102359 cites W1971065423 @default.
• W3217102359 cites W1980174384 @default.
• W3217102359 cites W1985181188 @default.
• W3217102359 cites W1986315531 @default.
• W3217102359 cites W1986803467 @default.
• W3217102359 cites W1988458651 @default.
• W3217102359 cites W1991133811 @default.
• W3217102359 cites W1993116843 @default.
• W3217102359 cites W1993751578 @default.
• W3217102359 cites W1994133347 @default.
• W3217102359 cites W2004726009 @default.
• W3217102359 cites W2005771030 @default.
• W3217102359 cites W2015497529 @default.
• W3217102359 cites W2019151860 @default.
• W3217102359 cites W2032913523 @default.
• W3217102359 cites W2035242178 @default.
• W3217102359 cites W2051101763 @default.
• W3217102359 cites W2054745605 @default.
• W3217102359 cites W2055264375 @default.
• W3217102359 cites W2057910069 @default.
• W3217102359 cites W2058790172 @default.
• W3217102359 cites W2059486762 @default.
• W3217102359 cites W2064064548 @default.
• W3217102359 cites W2064093384 @default.
• W3217102359 cites W2066685510 @default.
• W3217102359 cites W2084122112 @default.
• W3217102359 cites W2085435601 @default.
• W3217102359 cites W2095161148 @default.
• W3217102359 cites W2096753387 @default.
• W3217102359 cites W2097463789 @default.
• W3217102359 cites W2099769485 @default.
• W3217102359 cites W2101039659 @default.
• W3217102359 cites W2103495463 @default.
• W3217102359 cites W2104558356 @default.
• W3217102359 cites W2108813495 @default.
• W3217102359 cites W2109231206 @default.
• W3217102359 cites W2110634891 @default.
• W3217102359 cites W2114932791 @default.
• W3217102359 cites W2117491442 @default.
• W3217102359 cites W2118400571 @default.
• W3217102359 cites W2118537722 @default.
• W3217102359 cites W2119483296 @default.
• W3217102359 cites W2130775443 @default.
• W3217102359 cites W2134595043 @default.
• W3217102359 cites W2136603226 @default.
• W3217102359 cites W2136752250 @default.
• W3217102359 cites W2137059909 @default.
• W3217102359 cites W2143463421 @default.
• W3217102359 cites W2146674508 @default.
• W3217102359 cites W2159430424 @default.
• W3217102359 cites W2161308892 @default.
• W3217102359 cites W2162286513 @default.
• W3217102359 cites W2168888135 @default.
• W3217102359 cites W2171887211 @default.
• W3217102359 cites W2176745654 @default.
• W3217102359 cites W2279875163 @default.
• W3217102359 cites W2410325454 @default.
• W3217102359 cites W2556359407 @default.
• W3217102359 cites W2558778180 @default.
• W3217102359 cites W2600481111 @default.
• W3217102359 cites W2753260601 @default.
• W3217102359 cites W2766476830 @default.
• W3217102359 cites W2785308950 @default.
• W3217102359 cites W2800716076 @default.
• W3217102359 cites W2807310111 @default.
• W3217102359 cites W2883589380 @default.
• W3217102359 cites W2885564016 @default.
• W3217102359 cites W2901509748 @default.
• W3217102359 cites W2914579784 @default.
• W3217102359 cites W2927871970 @default.
• W3217102359 cites W2938469046 @default.
• W3217102359 cites W2950592329 @default.
• W3217102359 cites W2962616530 @default.
• W3217102359 cites W2967918238 @default.
• W3217102359 cites W2995521654 @default.
• W3217102359 cites W2996290697 @default.
• W3217102359 cites W3004709581 @default.
• W3217102359 cites W3017437420 @default.

• next