Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217102385> ?p ?o ?g. }
- W3217102385 endingPage "12469" @default.
- W3217102385 startingPage "12469" @default.
- W3217102385 abstract "The aim of this study was to analyze the expression of peroxisome proliferator-activated receptor γ (PPARγ) and retinoid X receptor α (RxRα), a binding heterodimer playing a pivotal role in the successful trophoblast invasion, in the placental tissue of preeclamptic patients. Furthermore, we aimed to characterize a possible interaction between PPARγ and H3K4me3 (trimethylated lysine 4 of the histone H3), respectively H3K9ac (acetylated lysine 9 of the histone H3), to illuminate the role of histone modifications in a defective trophoblast invasion in preeclampsia (PE). Therefore, the expression of PPARγ and RxRα was analyzed in 26 PE and 25 control placentas by immunohistochemical peroxidase staining, as well as the co-expression with H3K4me3 and H3K9ac by double immunofluorescence staining. Further, the effect of a specific PPARγ-agonist (Ciglitazone) and PPARγ-antagonist (T0070907) on the histone modifications H3K9ac and H3K4me3 was analyzed in vitro. In PE placentas, we found a reduced expression of PPARγ and RxRα and a reduced co-expression with H3K4me3 and H3K9ac in the extravillous trophoblast (EVT). Furthermore, with the PPARγ-antagonist treated human villous trophoblast (HVT) cells and primary isolated EVT cells showed higher levels of the histone modification proteins whereas treatment with the PPARγ-agonist reduced respective histone modifications. Our results show that the stimulation of PPARγ-activity leads to a reduction of H3K4me3 and H3K9ac in trophoblast cells, but paradoxically decreases the nuclear PPARγ expression. As the importance of PPARγ, being involved in a successful trophoblast invasion has already been investigated, our results reveal a pathophysiologic connection between PPARγ and the epigenetic modulation via H3K4me3 and H3K9ac in PE." @default.
- W3217102385 created "2021-12-06" @default.
- W3217102385 creator A5004434507 @default.
- W3217102385 creator A5027564901 @default.
- W3217102385 creator A5045019134 @default.
- W3217102385 creator A5047035598 @default.
- W3217102385 creator A5050124544 @default.
- W3217102385 creator A5050620070 @default.
- W3217102385 creator A5056412323 @default.
- W3217102385 creator A5061067586 @default.
- W3217102385 creator A5063206238 @default.
- W3217102385 creator A5064774672 @default.
- W3217102385 creator A5074768700 @default.
- W3217102385 creator A5075514056 @default.
- W3217102385 creator A5089842210 @default.
- W3217102385 date "2021-11-18" @default.
- W3217102385 modified "2023-10-16" @default.
- W3217102385 title "Regulation of Epigenetic Modifications in the Placenta during Preeclampsia: PPARγ Influences H3K4me3 and H3K9ac in Extravillous Trophoblast Cells" @default.
- W3217102385 cites W1479945039 @default.
- W3217102385 cites W1493790476 @default.
- W3217102385 cites W1968703258 @default.
- W3217102385 cites W1971997894 @default.
- W3217102385 cites W1983874629 @default.
- W3217102385 cites W1984472867 @default.
- W3217102385 cites W1986588381 @default.
- W3217102385 cites W1987613776 @default.
- W3217102385 cites W1989838345 @default.
- W3217102385 cites W1995640546 @default.
- W3217102385 cites W2004382470 @default.
- W3217102385 cites W2007721877 @default.
- W3217102385 cites W2011657944 @default.
- W3217102385 cites W2012129725 @default.
- W3217102385 cites W2017621318 @default.
- W3217102385 cites W2022542452 @default.
- W3217102385 cites W2040558778 @default.
- W3217102385 cites W2046532245 @default.
- W3217102385 cites W2051808143 @default.
- W3217102385 cites W2060583339 @default.
- W3217102385 cites W2076891180 @default.
- W3217102385 cites W2086984024 @default.
- W3217102385 cites W2088258048 @default.
- W3217102385 cites W2100265114 @default.
- W3217102385 cites W2107954313 @default.
- W3217102385 cites W2113497156 @default.
- W3217102385 cites W2119468520 @default.
- W3217102385 cites W2122595500 @default.
- W3217102385 cites W2126584395 @default.
- W3217102385 cites W2133571440 @default.
- W3217102385 cites W2136871997 @default.
- W3217102385 cites W2138046813 @default.
- W3217102385 cites W2141003443 @default.
- W3217102385 cites W2145277495 @default.
- W3217102385 cites W2150557496 @default.
- W3217102385 cites W2150967160 @default.
- W3217102385 cites W2163810943 @default.
- W3217102385 cites W2167950650 @default.
- W3217102385 cites W2168547139 @default.
- W3217102385 cites W2168876209 @default.
- W3217102385 cites W2170052737 @default.
- W3217102385 cites W2315930926 @default.
- W3217102385 cites W2346555940 @default.
- W3217102385 cites W2511292728 @default.
- W3217102385 cites W2516635595 @default.
- W3217102385 cites W2547439540 @default.
- W3217102385 cites W2569817636 @default.
- W3217102385 cites W2571378738 @default.
- W3217102385 cites W2577081443 @default.
- W3217102385 cites W2735588762 @default.
- W3217102385 cites W2752391781 @default.
- W3217102385 cites W2769952995 @default.
- W3217102385 cites W2889635553 @default.
- W3217102385 cites W2890206059 @default.
- W3217102385 cites W2923589336 @default.
- W3217102385 cites W2929300773 @default.
- W3217102385 cites W2931032704 @default.
- W3217102385 cites W2942680836 @default.
- W3217102385 cites W2944581763 @default.
- W3217102385 cites W2946094393 @default.
- W3217102385 cites W2950248832 @default.
- W3217102385 cites W2963386507 @default.
- W3217102385 cites W2966060798 @default.
- W3217102385 cites W2979112144 @default.
- W3217102385 cites W2979996325 @default.
- W3217102385 cites W2998013717 @default.
- W3217102385 cites W3007353241 @default.
- W3217102385 cites W3008711333 @default.
- W3217102385 cites W3010893915 @default.
- W3217102385 cites W3014025896 @default.
- W3217102385 cites W3123169824 @default.
- W3217102385 cites W3129977560 @default.
- W3217102385 cites W3148077615 @default.
- W3217102385 cites W4248638442 @default.
- W3217102385 cites W2904415784 @default.
- W3217102385 doi "https://doi.org/10.3390/ijms222212469" @default.
- W3217102385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8622744" @default.
- W3217102385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34830351" @default.
- W3217102385 hasPublicationYear "2021" @default.
- W3217102385 type Work @default.