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• W3217102710 abstract "Variant allele frequencies (VAF) encode ongoing evolution and subclonal selection in growing tumours. However, existing methods that utilize VAF information for cancer evolutionary inference are compressive, slow, or incorrectly specify the underlying cancer evolutionary dynamics. Here, we provide a proof-of-principle synthetic supervised learning method, TumE, that integrates simulated models of cancer evolution with Bayesian neural networks, to infer ongoing selection in bulk-sequenced single tumour biopsies. Analyses in synthetic and patient tumours shows that TumE significantly improves both accuracy and inference time per sample when detecting positive selection, deconvoluting selected subclonal populations, and estimating subclone frequency. Importantly, we show how transfer learning can leverage stored knowledge within TumE models for related evolutionary inference tasks — substantially reducing data and computational time for further model development and providing a library of recyclable deep learning models for the cancer evolution community. This extensible framework provides a foundation and future directions for harnessing progressive computational methods for the benefit of cancer genomics and, in turn, the cancer patient. TumE is publicly available for use at https://github.com/tomouellette/TumE." @default.
• W3217102710 created "2021-12-06" @default.
• W3217102710 creator A5005537625 @default.
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• W3217102710 date "2021-11-22" @default.
• W3217102710 modified "2023-09-27" @default.
• W3217102710 title "Inferring ongoing cancer evolution from single tumour biopsies using synthetic supervised learning" @default.
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• W3217102710 doi "https://doi.org/10.1101/2021.11.22.469566" @default.
• W3217102710 hasPublicationYear "2021" @default.
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