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• W3217104904 abstract "Gynecological illness accounts for around 4.5% of the global disease burden, which is higher than other key global health concerns such as malaria (1.04%), TB (1.9%), ischemic heart disease (2.2%), and maternal disorders (3.5%). Gynecological conditions in women of reproductive age are linked to both in terms of diagnosis and treatment, especially in low-income economies, which poses a serious social problem. A greater understanding of health promotion and illness management can help to prevent diseases in gynecology. Due to the lack of established biomarkers, the identification of gynecological diseases, including malignancies, has proven to be challenging in most situations, and histological exams remain the gold standard. Metalloproteinases (MMPs, ADAMs, ADAMTSs) and their endogenous inhibitors (TIMPs) modulate the protease-dependent bioavailability of local niche components (e.g., growth factors), matrix turnover, and cellular interactions to govern specific physical and biochemical characteristics of the environment. Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM), and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc-dependent endopeptidases that contribute significantly to the disintegration of extracellular matrix proteins and shedding of membrane-bound receptor molecules in several diseases, including arthritis. MMPs are noteworthy genes associated with cancer development, functional angiogenesis, invasion, metastasis, and immune surveillance evasion. These genes are often elevated in cancer and multiple benign gynecological disorders like endometriosis, according to research. Migration through the extracellular matrix, which involves proteolytic activity, is an essential step in tumor cell extravasation and metastasis. However, none of the MMPs' expression patterns, as well as their diagnostic and prognostic potential, have been studied in a pan-cancer context. The latter plays a very important role in cell signaling and might be used as a cancer treatment target. ADAMs are implicated in tumor cell proliferation, angiogenesis, and metastasis. This review will focus on the contribution of the aforementioned metalloproteinases in regulating gynecological disorders and their subsequent manipulation for therapeutic intervention." @default.
• W3217104904 created "2021-12-06" @default.
• W3217104904 creator A5017938926 @default.
• W3217104904 creator A5042847141 @default.
• W3217104904 creator A5056350390 @default.
• W3217104904 date "2021-11-29" @default.
• W3217104904 modified "2023-09-26" @default.
• W3217104904 title "Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases" @default.
• W3217104904 cites W1648593433 @default.
• W3217104904 cites W1930964488 @default.
• W3217104904 cites W1965037168 @default.
• W3217104904 cites W1965147884 @default.
• W3217104904 cites W1966399531 @default.
• W3217104904 cites W1969780570 @default.
• W3217104904 cites W1972019822 @default.
• W3217104904 cites W1974024530 @default.
• W3217104904 cites W1977861166 @default.
• W3217104904 cites W1981610638 @default.
• W3217104904 cites W1986738035 @default.
• W3217104904 cites W1987825791 @default.
• W3217104904 cites W1989003785 @default.
• W3217104904 cites W1992816401 @default.
• W3217104904 cites W2003500892 @default.
• W3217104904 cites W2005334224 @default.
• W3217104904 cites W2008765508 @default.
• W3217104904 cites W2009212230 @default.
• W3217104904 cites W2009507265 @default.
• W3217104904 cites W2010480763 @default.
• W3217104904 cites W2017183206 @default.
• W3217104904 cites W2034992352 @default.
• W3217104904 cites W2035084522 @default.
• W3217104904 cites W2040886298 @default.
• W3217104904 cites W2049797121 @default.
• W3217104904 cites W2051994734 @default.
• W3217104904 cites W2054953379 @default.
• W3217104904 cites W2061399161 @default.
• W3217104904 cites W2072219853 @default.
• W3217104904 cites W2082879053 @default.
• W3217104904 cites W2084298626 @default.
• W3217104904 cites W2086244192 @default.
• W3217104904 cites W2087973465 @default.
• W3217104904 cites W2089529051 @default.
• W3217104904 cites W2089646972 @default.
• W3217104904 cites W2103815419 @default.
• W3217104904 cites W2107166923 @default.
• W3217104904 cites W2108235071 @default.
• W3217104904 cites W2111230843 @default.
• W3217104904 cites W2114668235 @default.
• W3217104904 cites W2118000014 @default.
• W3217104904 cites W2132557164 @default.
• W3217104904 cites W2147469407 @default.
• W3217104904 cites W2151187602 @default.
• W3217104904 cites W2156470937 @default.
• W3217104904 cites W2159454395 @default.
• W3217104904 cites W2163519496 @default.
• W3217104904 cites W2170164215 @default.
• W3217104904 cites W2170192667 @default.
• W3217104904 cites W2172041325 @default.
• W3217104904 cites W2173069051 @default.
• W3217104904 cites W2232385876 @default.
• W3217104904 cites W2236813975 @default.
• W3217104904 cites W2338795774 @default.
• W3217104904 cites W2470057209 @default.
• W3217104904 cites W2507856777 @default.
• W3217104904 cites W2514975235 @default.
• W3217104904 cites W2529643212 @default.
• W3217104904 cites W2549249510 @default.
• W3217104904 cites W2563114544 @default.
• W3217104904 cites W2587816384 @default.
• W3217104904 cites W2589500190 @default.
• W3217104904 cites W2594569109 @default.
• W3217104904 cites W2617464025 @default.
• W3217104904 cites W2617674122 @default.
• W3217104904 cites W2623637971 @default.
• W3217104904 cites W2659780310 @default.
• W3217104904 cites W2754385197 @default.
• W3217104904 cites W2771491442 @default.
• W3217104904 cites W2786987313 @default.
• W3217104904 cites W2789129937 @default.
• W3217104904 cites W2793141200 @default.
• W3217104904 cites W2800376069 @default.
• W3217104904 cites W2802126353 @default.
• W3217104904 cites W2804585777 @default.
• W3217104904 cites W2805560872 @default.
• W3217104904 cites W2807713137 @default.
• W3217104904 cites W2808032469 @default.
• W3217104904 cites W2883797574 @default.
• W3217104904 cites W2889646458 @default.
• W3217104904 cites W2891602242 @default.
• W3217104904 cites W2891836094 @default.
• W3217104904 cites W2895377702 @default.
• W3217104904 cites W2906120852 @default.
• W3217104904 cites W2919287544 @default.
• W3217104904 cites W2937993724 @default.
• W3217104904 cites W2940989432 @default.
• W3217104904 cites W2941734048 @default.
• W3217104904 cites W2942550960 @default.
• W3217104904 cites W2970104014 @default.
• W3217104904 cites W2970147026 @default.
• W3217104904 cites W2976200440 @default.

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