Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217170401> ?p ?o ?g. }
- W3217170401 endingPage "2224" @default.
- W3217170401 startingPage "2209" @default.
- W3217170401 abstract "The process of recombination between variable (V), diversity (D), and joining (J) immunoglobulin (Ig) gene segments determines an individual's naive Ig repertoire and, consequently, (auto)antigen recognition. VDJ recombination follows probabilistic rules that can be modeled statistically. So far, it remains unknown whether VDJ recombination rules differ between individuals. If these rules differed, identical (auto)antigen-specific Ig sequences would be generated with individual-specific probabilities, signifying that the available Ig sequence space is individual specific. We devised a sensitivity-tested distance measure that enables inter-individual comparison of VDJ recombination models. We discovered, accounting for several sources of noise as well as allelic variation in Ig sequencing data, that not only unrelated individuals but also human monozygotic twins and even inbred mice possess statistically distinguishable immunoglobulin recombination models. This suggests that, in addition to genetic, there is also nongenetic modulation of VDJ recombination. We demonstrate that population-wide individualized VDJ recombination can result in orders of magnitude of difference in the probability to generate (auto)antigen-specific Ig sequences. Our findings have implications for immune receptor-based individualized medicine approaches relevant to vaccination, infection, and autoimmunity." @default.
- W3217170401 created "2021-12-06" @default.
- W3217170401 creator A5000751357 @default.
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- W3217170401 creator A5088612281 @default.
- W3217170401 creator A5089158926 @default.
- W3217170401 date "2021-11-23" @default.
- W3217170401 modified "2023-10-16" @default.
- W3217170401 title "Individualized VDJ recombination predisposes the available Ig sequence space" @default.
- W3217170401 cites W1423495995 @default.
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- W3217170401 cites W1999033892 @default.
- W3217170401 cites W2011301426 @default.
- W3217170401 cites W2022824615 @default.
- W3217170401 cites W2027515257 @default.
- W3217170401 cites W2029525307 @default.
- W3217170401 cites W2055519354 @default.
- W3217170401 cites W2073626079 @default.
- W3217170401 cites W2089041106 @default.
- W3217170401 cites W2108147510 @default.
- W3217170401 cites W2115122333 @default.
- W3217170401 cites W2134555277 @default.
- W3217170401 cites W2170654913 @default.
- W3217170401 cites W2172104507 @default.
- W3217170401 cites W2295956658 @default.
- W3217170401 cites W2310172832 @default.
- W3217170401 cites W2317651087 @default.
- W3217170401 cites W2337033889 @default.
- W3217170401 cites W2491494855 @default.
- W3217170401 cites W2509135402 @default.
- W3217170401 cites W2528563747 @default.
- W3217170401 cites W2547929624 @default.
- W3217170401 cites W2565989705 @default.
- W3217170401 cites W2580786722 @default.
- W3217170401 cites W2593304336 @default.
- W3217170401 cites W2594174650 @default.
- W3217170401 cites W2605177850 @default.
- W3217170401 cites W2605350170 @default.
- W3217170401 cites W2613371971 @default.
- W3217170401 cites W2615390960 @default.
- W3217170401 cites W2616207459 @default.
- W3217170401 cites W2623523065 @default.
- W3217170401 cites W2774014537 @default.
- W3217170401 cites W2902244694 @default.
- W3217170401 cites W2910384850 @default.
- W3217170401 cites W2912715963 @default.
- W3217170401 cites W2915323148 @default.
- W3217170401 cites W2924247059 @default.
- W3217170401 cites W2928755087 @default.
- W3217170401 cites W2950234903 @default.
- W3217170401 cites W2950612260 @default.
- W3217170401 cites W2951124440 @default.
- W3217170401 cites W2955930170 @default.
- W3217170401 cites W2962886702 @default.
- W3217170401 cites W2971575097 @default.
- W3217170401 cites W2975204303 @default.
- W3217170401 cites W2977872441 @default.
- W3217170401 cites W2991336382 @default.
- W3217170401 cites W3004586992 @default.
- W3217170401 cites W3004894219 @default.
- W3217170401 cites W3007865917 @default.
- W3217170401 cites W3019459038 @default.
- W3217170401 cites W3022219237 @default.
- W3217170401 cites W3034425032 @default.
- W3217170401 cites W3045578670 @default.
- W3217170401 cites W3049166744 @default.
- W3217170401 cites W3049464942 @default.
- W3217170401 cites W3081495071 @default.
- W3217170401 cites W3083146163 @default.
- W3217170401 cites W3087502482 @default.
- W3217170401 cites W3088674399 @default.
- W3217170401 cites W3094103060 @default.
- W3217170401 cites W3095930322 @default.
- W3217170401 cites W3100486620 @default.
- W3217170401 cites W3102596196 @default.
- W3217170401 cites W3102740321 @default.
- W3217170401 cites W3111056735 @default.
- W3217170401 cites W3120048001 @default.
- W3217170401 cites W3120990821 @default.
- W3217170401 cites W3122747834 @default.
- W3217170401 cites W3124309814 @default.
- W3217170401 cites W3125723159 @default.
- W3217170401 cites W3135351475 @default.
- W3217170401 cites W3137476122 @default.
- W3217170401 cites W3138783506 @default.