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• W3217177281 abstract "Melanoma brain metastasis (MBM) generally portends a dismal prognosis. Simultaneous use of radiotherapy (RT) and immune checkpoint inhibitor (ICI) therapy demonstrated tremendous promise and emerged as the new standard. This meta-analysis was conducted to evaluate survival outcomes and toxicities of this combination in patients with MBM. Data analyses were performed using Comprehensive Meta-Analysis software (version 2) and IBM SPSS software (version 27). A systematic literature search of PubMed, EMBASE, and the Cochrane Library (via Wiley) was conducted using PICOS/PRISMA selection protocol and included studies to evaluate survival and safety-associated outcomes of ICI + RT for the treatment of MBM. A total 44 studies involving 2498 patients were reviewed. The pooled effect size (ES) for overall survival (OS) to compare the ICI + RT arm and ICI alone arm (HR: 0.693 [0.526–0.913, p = .001]), and compare the ICI + RT arm and brain RT alone (HR: 0.595 [0.489–0.723, p < .001)] indicated better survival outcomes in ICI + RT versus RT alone and ICI alone arms. Comparing central nervous system toxicity in the ICI + RT arm and RT alone arm, the pooled ES Grade ≥ 3 neurologic adverse events (NAEs) risk ratio ([RR] = 1.425; 95% confidence interval [CI]: 0.485–4.183; p = .519) indicated that ICI + RT nonsignificantly increased Grade 3–4 NAEs. Comparing Grade ≥ 3 radiation necrosis in the ICI + RT arm and RT alone arm, the pooled ES RR (RR = 2.73; 95% CI: 0.59–12.59; p = .199) indicated that ICI + RT nonsignificantly increased Grade ≥ 3 radiation necrosis. Concurrent administration of RT and ICI evinced favorable OS outcomes and acceptable safety profile in MBM patients. Planned prospective trials are required to demonstrate the issue." @default.
• W3217177281 created "2021-12-06" @default.
• W3217177281 creator A5005841852 @default.
• W3217177281 creator A5008126259 @default.
• W3217177281 creator A5009091027 @default.
• W3217177281 date "2021-12-01" @default.
• W3217177281 modified "2023-10-18" @default.
• W3217177281 title "Radiotherapy and immunotherapy in melanoma brain metastases" @default.
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• W3217177281 doi "https://doi.org/10.1016/j.hemonc.2021.11.001" @default.
• W3217177281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36634277" @default.

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