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- W3217184585 abstract "Alcohol use disorder (AUD) is a chronic, relapsing brain disorder, characterized by compulsive alcohol seeking and disrupted brain function. In individuals with AUD, abstinence from alcohol often precipitates withdrawal symptoms than can be life threatening. Here, we review evidence for nutritional ketosis as a potential means to reduce withdrawal and alcohol craving. We also review the underlying mechanisms of action of ketosis. Several findings suggest that during alcohol intoxication there is a shift from glucose to acetate metabolism that is enhanced in individuals with AUD. During withdrawal, there is a decline in acetate levels that can result in an energy deficit and could contribute to neurotoxicity. A ketogenic diet or ingestion of a ketone ester elevates ketone bodies (acetoacetate, β-hydroxybutyrate and acetone) in plasma and brain, resulting in nutritional ketosis. These effects have been shown to reduce alcohol withdrawal symptoms, alcohol craving, and alcohol consumption in both preclinical and clinical studies. Thus, nutritional ketosis may represent a unique treatment option for AUD: namely, a nutritional intervention that could be used alone or to augment the effects of medications." @default.
- W3217184585 created "2021-12-06" @default.
- W3217184585 creator A5002969658 @default.
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- W3217184585 creator A5085936446 @default.
- W3217184585 date "2021-11-30" @default.
- W3217184585 modified "2023-10-03" @default.
- W3217184585 title "Nutritional Ketosis as a Potential Treatment for Alcohol Use Disorder" @default.
- W3217184585 cites W106360673 @default.
- W3217184585 cites W1702768646 @default.
- W3217184585 cites W1759750343 @default.
- W3217184585 cites W1932004110 @default.
- W3217184585 cites W1963876508 @default.
- W3217184585 cites W1966181749 @default.
- W3217184585 cites W1966556786 @default.
- W3217184585 cites W1968091833 @default.
- W3217184585 cites W1969275215 @default.
- W3217184585 cites W1971675645 @default.
- W3217184585 cites W1972648828 @default.
- W3217184585 cites W1974633668 @default.
- W3217184585 cites W1976994483 @default.
- W3217184585 cites W1977491864 @default.
- W3217184585 cites W1983397453 @default.
- W3217184585 cites W1991222922 @default.
- W3217184585 cites W1993891203 @default.
- W3217184585 cites W1994749127 @default.
- W3217184585 cites W1995315224 @default.
- W3217184585 cites W2000147796 @default.
- W3217184585 cites W2001639140 @default.
- W3217184585 cites W2004320707 @default.
- W3217184585 cites W2004813308 @default.
- W3217184585 cites W2004923528 @default.
- W3217184585 cites W2005063766 @default.
- W3217184585 cites W2008316295 @default.
- W3217184585 cites W2010511534 @default.
- W3217184585 cites W2011578117 @default.
- W3217184585 cites W2017228134 @default.
- W3217184585 cites W2020958481 @default.
- W3217184585 cites W2031994161 @default.
- W3217184585 cites W2037590564 @default.
- W3217184585 cites W2037882044 @default.
- W3217184585 cites W2038863889 @default.
- W3217184585 cites W2041862342 @default.
- W3217184585 cites W2042377182 @default.
- W3217184585 cites W2043095313 @default.
- W3217184585 cites W2046864229 @default.
- W3217184585 cites W2047898810 @default.
- W3217184585 cites W2049290442 @default.
- W3217184585 cites W2050055596 @default.
- W3217184585 cites W2058707813 @default.
- W3217184585 cites W2063780307 @default.
- W3217184585 cites W2069302715 @default.
- W3217184585 cites W2070376390 @default.
- W3217184585 cites W2074611211 @default.
- W3217184585 cites W2074899354 @default.
- W3217184585 cites W2075276600 @default.
- W3217184585 cites W2077741298 @default.
- W3217184585 cites W2079709825 @default.
- W3217184585 cites W2080137002 @default.
- W3217184585 cites W2081262717 @default.
- W3217184585 cites W2082915290 @default.
- W3217184585 cites W2085025746 @default.
- W3217184585 cites W2086294393 @default.
- W3217184585 cites W2087201094 @default.
- W3217184585 cites W2088349062 @default.
- W3217184585 cites W2088700698 @default.
- W3217184585 cites W2089753821 @default.
- W3217184585 cites W2095013890 @default.
- W3217184585 cites W2097823370 @default.
- W3217184585 cites W2099287991 @default.
- W3217184585 cites W2100322766 @default.
- W3217184585 cites W2101304481 @default.
- W3217184585 cites W2104284600 @default.
- W3217184585 cites W2106036385 @default.
- W3217184585 cites W2106175914 @default.
- W3217184585 cites W2106923624 @default.
- W3217184585 cites W2109421548 @default.
- W3217184585 cites W2111704780 @default.
- W3217184585 cites W2112929255 @default.
- W3217184585 cites W2113650366 @default.
- W3217184585 cites W2114020311 @default.
- W3217184585 cites W2116035317 @default.
- W3217184585 cites W2117309102 @default.
- W3217184585 cites W2117482209 @default.
- W3217184585 cites W2117497424 @default.
- W3217184585 cites W2119197433 @default.
- W3217184585 cites W2120386072 @default.
- W3217184585 cites W2125365870 @default.
- W3217184585 cites W2126594232 @default.
- W3217184585 cites W2130935482 @default.
- W3217184585 cites W2134619125 @default.
- W3217184585 cites W2136503478 @default.
- W3217184585 cites W2137516476 @default.
- W3217184585 cites W2138269418 @default.