FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217194476> ?p ?o ?g. }

• W3217194476 endingPage "100011" @default.
• W3217194476 startingPage "100011" @default.
• W3217194476 abstract "Abnormal proliferation of T cells plays an essential role in the pathogenesis of Systemic lupus erythematosus (SLE). The pharmaceutical effect of Hedyotis Diffusa Willd (HDW) on SLE has been investigated previously. Nevertheless, the biomedical mechanism is still left unclear. This study has been arranged to evaluate the therapeutic effect of the ethyl acetate fraction of HDW (EAHDW) on lupus mice and explore the potential therapeutic mechanism. EAHDW was prepared with 80% ethanol reflex extraction followed by successive extraction, and analyzed with HPLC and UPLC-Q/TOP-MS. The potential targets and STAT3 affinity regulators were predicted with network pharmacology. The pharmaceutic effect of EAHDW was studied with MRL/lpr mice. Cytokines and autoantibodies were quantified with ELISA assays. The pathological damage of glomerulus and STAT3 expression in the kidney was detected with histochemical and immunohistochemical techniques. The cell cycle properties in cell proliferation were identified with the flow cytometry. The western blot and dual-Luciferase reporter assay were applied to evaluate translational and transcriptional activity of STAT3, respectively. In this study, the extraction ratio of EAHDW was 2.7±1%, in which 19 ingredients were identified. Network pharmacological analysis showed that the target genes of EAHDW were highly focused on influencing the abnormal T cell proliferation in SLE. EAHDW showed the beneficial effects on pathological changes and STAT3 expression in the glomerulus of lupus mice, and the levels of cytokines and autoantibodies in serum. In cytological study, EAHDW treatment attenuated the transcription and phosphorylation of STAT3, which inhibited T cell proliferation by prolonged S-phase of the cell cycle. A total of 5 compounds in EAHDW exhibited high docking affinity to the DNA-binding site of STAT3. EAHDW could reduce the inflammatory response and inhibit the proliferation of T cells by interfering with the STAT3 signaling pathway, thereby playing a therapeutic effect on SLE." @default.
• W3217194476 created "2021-12-06" @default.
• W3217194476 creator A5003920013 @default.
• W3217194476 creator A5015418052 @default.
• W3217194476 creator A5043318906 @default.
• W3217194476 creator A5060002817 @default.
• W3217194476 creator A5067910249 @default.
• W3217194476 creator A5068085404 @default.
• W3217194476 creator A5077104843 @default.
• W3217194476 creator A5087086522 @default.
• W3217194476 creator A5088579241 @default.
• W3217194476 date "2021-12-01" @default.
• W3217194476 modified "2023-09-27" @default.
• W3217194476 title "Ethyl Acetate Fraction in Hedyotis Diffusa Willd Inhibits T Cell Proliferation to Improve the Pathogenesis of Systemic Lupus Erythematosus" @default.
• W3217194476 cites W1824670638 @default.
• W3217194476 cites W1859966362 @default.
• W3217194476 cites W1964046646 @default.
• W3217194476 cites W1966771484 @default.
• W3217194476 cites W1972245033 @default.
• W3217194476 cites W1973603971 @default.
• W3217194476 cites W1980025905 @default.
• W3217194476 cites W1982595442 @default.
• W3217194476 cites W1985533946 @default.
• W3217194476 cites W2072377663 @default.
• W3217194476 cites W2086840459 @default.
• W3217194476 cites W2103540095 @default.
• W3217194476 cites W2131746203 @default.
• W3217194476 cites W2201109758 @default.
• W3217194476 cites W2513992493 @default.
• W3217194476 cites W2761098930 @default.
• W3217194476 cites W2765434473 @default.
• W3217194476 cites W2775811092 @default.
• W3217194476 cites W2792167994 @default.
• W3217194476 cites W2802456429 @default.
• W3217194476 cites W2811490671 @default.
• W3217194476 cites W2897169825 @default.
• W3217194476 cites W2900950647 @default.
• W3217194476 cites W2948214599 @default.
• W3217194476 cites W2954498505 @default.
• W3217194476 cites W2972099417 @default.
• W3217194476 cites W2975203734 @default.
• W3217194476 cites W2979308218 @default.
• W3217194476 cites W2982116988 @default.
• W3217194476 cites W2986126697 @default.
• W3217194476 cites W2995560263 @default.
• W3217194476 cites W3071028727 @default.
• W3217194476 cites W3142830093 @default.
• W3217194476 doi "https://doi.org/10.1016/j.ccmp.2021.100011" @default.
• W3217194476 hasPublicationYear "2021" @default.
• W3217194476 type Work @default.
• W3217194476 sameAs 3217194476 @default.
• W3217194476 citedByCount "0" @default.
• W3217194476 crossrefType "journal-article" @default.
• W3217194476 hasAuthorship W3217194476A5003920013 @default.
• W3217194476 hasAuthorship W3217194476A5015418052 @default.
• W3217194476 hasAuthorship W3217194476A5043318906 @default.
• W3217194476 hasAuthorship W3217194476A5060002817 @default.
• W3217194476 hasAuthorship W3217194476A5067910249 @default.
• W3217194476 hasAuthorship W3217194476A5068085404 @default.
• W3217194476 hasAuthorship W3217194476A5077104843 @default.
• W3217194476 hasAuthorship W3217194476A5087086522 @default.
• W3217194476 hasAuthorship W3217194476A5088579241 @default.
• W3217194476 hasBestOaLocation W32171944761 @default.
• W3217194476 hasConcept C104317684 @default.
• W3217194476 hasConcept C126322002 @default.
• W3217194476 hasConcept C185592680 @default.
• W3217194476 hasConcept C190283241 @default.
• W3217194476 hasConcept C203014093 @default.
• W3217194476 hasConcept C2776415932 @default.
• W3217194476 hasConcept C2778923194 @default.
• W3217194476 hasConcept C2779134260 @default.
• W3217194476 hasConcept C2779912601 @default.
• W3217194476 hasConcept C2780942790 @default.
• W3217194476 hasConcept C29537977 @default.
• W3217194476 hasConcept C553184892 @default.
• W3217194476 hasConcept C55493867 @default.
• W3217194476 hasConcept C62112901 @default.
• W3217194476 hasConcept C71924100 @default.
• W3217194476 hasConcept C86803240 @default.
• W3217194476 hasConcept C98274493 @default.
• W3217194476 hasConceptScore W3217194476C104317684 @default.
• W3217194476 hasConceptScore W3217194476C126322002 @default.
• W3217194476 hasConceptScore W3217194476C185592680 @default.
• W3217194476 hasConceptScore W3217194476C190283241 @default.
• W3217194476 hasConceptScore W3217194476C203014093 @default.
• W3217194476 hasConceptScore W3217194476C2776415932 @default.
• W3217194476 hasConceptScore W3217194476C2778923194 @default.
• W3217194476 hasConceptScore W3217194476C2779134260 @default.
• W3217194476 hasConceptScore W3217194476C2779912601 @default.
• W3217194476 hasConceptScore W3217194476C2780942790 @default.
• W3217194476 hasConceptScore W3217194476C29537977 @default.
• W3217194476 hasConceptScore W3217194476C553184892 @default.
• W3217194476 hasConceptScore W3217194476C55493867 @default.
• W3217194476 hasConceptScore W3217194476C62112901 @default.
• W3217194476 hasConceptScore W3217194476C71924100 @default.
• W3217194476 hasConceptScore W3217194476C86803240 @default.
• W3217194476 hasConceptScore W3217194476C98274493 @default.
• W3217194476 hasFunder F4320321001 @default.

• next