FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217208723> ?p ?o ?g. }

• W3217208723 abstract "In addition to the well-known role of vitamin D in calcium homeostasis and bone metabolism, vitamin D is important in the modulation of the immune system and inflammatory processes. Vitamin D deficiency is common in patients with systemic lupus erythematosus (SLE), possibly as a result of sun avoidance. The aim of this prospective open-label study was to assess the effect of the treatment of vitamin D deficiency and insufficiency in SLE patients, particularly with regards to disease activity, fatigue and interferon signature gene expression.31 SLE patients, 13 with vitamin D deficiency and 18 with vitamin D insufficiency were treated with vitamin D3. They were supplemented with vitamin D3 8000 IU daily for 8 weeks if they were vitamin D deficient, or 8000 IU daily for 4 weeks if they were insufficient. This was followed by 2000 IU daily maintenance. They were assessed at baseline, after 6 and 12 months by means of an interview, filling in questionnaires and blood tests. The expression of 12 interferon signature genes in RNA extracted from whole blood was measured by using QuantiGene Plex technology.An improvement in disease activity measured by systemic lupus erythematosus disease activity index-2K (SLEDAI-2K; p = 0.028) and fatigue measured by fatigue severity scale (FSS; p = 0.071) at 12 months were noted. A significant decrease in anti-double stranded deoxyribonucleic acid (dsDNA) titre (p = 0.045) was also noted. The mean interferon signature gene expression score decreased from baseline to 6 months, however statistical significance was not achieved (p = 0.165).Improved disease activity and fatigue have been noted when Vitamin D has been supplemented in vitamin D deficient/insufficient SLE patients. One possible mechanism could be the suppression of the interferon signature gene expression.The study was registered with the ISRCTN registry on 12/04/2021 (Trial ID: ISRCTN59058825)." @default.
• W3217208723 created "2021-12-06" @default.
• W3217208723 creator A5014975313 @default.
• W3217208723 creator A5024064605 @default.
• W3217208723 creator A5027708771 @default.
• W3217208723 creator A5040104614 @default.
• W3217208723 creator A5041012266 @default.
• W3217208723 date "2021-12-01" @default.
• W3217208723 modified "2023-10-16" @default.
• W3217208723 title "Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression" @default.
• W3217208723 cites W1608831349 @default.
• W3217208723 cites W1982176411 @default.
• W3217208723 cites W1984323294 @default.
• W3217208723 cites W1985782704 @default.
• W3217208723 cites W1998411000 @default.
• W3217208723 cites W2022977540 @default.
• W3217208723 cites W2054089787 @default.
• W3217208723 cites W2054341704 @default.
• W3217208723 cites W2064179993 @default.
• W3217208723 cites W2094999646 @default.
• W3217208723 cites W2099546294 @default.
• W3217208723 cites W2101904342 @default.
• W3217208723 cites W2112398552 @default.
• W3217208723 cites W2114242035 @default.
• W3217208723 cites W2115891889 @default.
• W3217208723 cites W2121281629 @default.
• W3217208723 cites W2123989297 @default.
• W3217208723 cites W2146660377 @default.
• W3217208723 cites W2151487996 @default.
• W3217208723 cites W2152772362 @default.
• W3217208723 cites W2159860161 @default.
• W3217208723 cites W2166281097 @default.
• W3217208723 cites W2167518746 @default.
• W3217208723 cites W2171394603 @default.
• W3217208723 cites W2253972201 @default.
• W3217208723 cites W2416242818 @default.
• W3217208723 cites W2620741325 @default.
• W3217208723 cites W2733456605 @default.
• W3217208723 cites W3092233366 @default.
• W3217208723 cites W3201965154 @default.
• W3217208723 cites W911382732 @default.
• W3217208723 doi "https://doi.org/10.1186/s41927-021-00223-1" @default.
• W3217208723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34857051" @default.
• W3217208723 hasPublicationYear "2021" @default.
• W3217208723 type Work @default.
• W3217208723 sameAs 3217208723 @default.
• W3217208723 citedByCount "12" @default.
• W3217208723 countsByYear W32172087232022 @default.
• W3217208723 countsByYear W32172087232023 @default.
• W3217208723 crossrefType "journal-article" @default.
• W3217208723 hasAuthorship W3217208723A5014975313 @default.
• W3217208723 hasAuthorship W3217208723A5024064605 @default.
• W3217208723 hasAuthorship W3217208723A5027708771 @default.
• W3217208723 hasAuthorship W3217208723A5040104614 @default.
• W3217208723 hasAuthorship W3217208723A5041012266 @default.
• W3217208723 hasBestOaLocation W32172087231 @default.
• W3217208723 hasConcept C124490489 @default.
• W3217208723 hasConcept C126322002 @default.
• W3217208723 hasConcept C134018914 @default.
• W3217208723 hasConcept C159654299 @default.
• W3217208723 hasConcept C203014093 @default.
• W3217208723 hasConcept C2775915377 @default.
• W3217208723 hasConcept C2776178377 @default.
• W3217208723 hasConcept C2776912625 @default.
• W3217208723 hasConcept C2776940978 @default.
• W3217208723 hasConcept C2779134260 @default.
• W3217208723 hasConcept C2779740938 @default.
• W3217208723 hasConcept C71924100 @default.
• W3217208723 hasConcept C8891405 @default.
• W3217208723 hasConceptScore W3217208723C124490489 @default.
• W3217208723 hasConceptScore W3217208723C126322002 @default.
• W3217208723 hasConceptScore W3217208723C134018914 @default.
• W3217208723 hasConceptScore W3217208723C159654299 @default.
• W3217208723 hasConceptScore W3217208723C203014093 @default.
• W3217208723 hasConceptScore W3217208723C2775915377 @default.
• W3217208723 hasConceptScore W3217208723C2776178377 @default.
• W3217208723 hasConceptScore W3217208723C2776912625 @default.
• W3217208723 hasConceptScore W3217208723C2776940978 @default.
• W3217208723 hasConceptScore W3217208723C2779134260 @default.
• W3217208723 hasConceptScore W3217208723C2779740938 @default.
• W3217208723 hasConceptScore W3217208723C71924100 @default.
• W3217208723 hasConceptScore W3217208723C8891405 @default.
• W3217208723 hasIssue "1" @default.
• W3217208723 hasLocation W32172087231 @default.
• W3217208723 hasLocation W32172087232 @default.
• W3217208723 hasLocation W32172087233 @default.
• W3217208723 hasLocation W32172087234 @default.
• W3217208723 hasLocation W32172087235 @default.
• W3217208723 hasOpenAccess W3217208723 @default.
• W3217208723 hasPrimaryLocation W32172087231 @default.
• W3217208723 hasRelatedWork W1824985903 @default.
• W3217208723 hasRelatedWork W1967386430 @default.
• W3217208723 hasRelatedWork W1975759361 @default.
• W3217208723 hasRelatedWork W2009546961 @default.
• W3217208723 hasRelatedWork W2071103727 @default.
• W3217208723 hasRelatedWork W2107762597 @default.
• W3217208723 hasRelatedWork W2107879638 @default.
• W3217208723 hasRelatedWork W2147487489 @default.
• W3217208723 hasRelatedWork W3022354617 @default.
• W3217208723 hasRelatedWork W4229053620 @default.

• next