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• W3217214903 startingPage "2672" @default.
• W3217214903 abstract "We hereby describe the process of design and selection of nonantibody protein binders mimicking cytokine signaling. We chose to mimic signaling of IFN-λ1, type 3 interferon (also known as IL-29) for its novelty and the importance of its biological functions. All four known interferons λ signal through binding to the extracellular domains of IL-28 receptor 1 (IL-28R1) and IL-10 receptor 2 (IL-10R2). Our binders were therefore trained to bind both receptors simultaneously. The bifunctional binder molecules were developed by yeast display, a method of directed evolution. The signaling capacity of the bivalent binders was tested by measuring phosphorylation of the JAK/STAT signaling pathway and production of mRNA of six selected genes naturally induced by IFN- λ1 in human cell lines. The newly developed bivalent binders offer opportunities to study cytokine-related biological functions and modulation of the cell behavior by receptor activation on the cell surfaces alternative to the use of natural IFN-λ." @default.
• W3217214903 created "2021-12-06" @default.
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• W3217214903 date "2021-12-07" @default.
• W3217214903 modified "2023-10-10" @default.
• W3217214903 title "<i>De novo</i> developed protein binders mimicking Interferon lambda signaling" @default.
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• W3217214903 doi "https://doi.org/10.1111/febs.16300" @default.
• W3217214903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34826176" @default.
• W3217214903 hasPublicationYear "2021" @default.
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