Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217221444> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3217221444 abstract "Background and aims: The rectosigmoid brake, characterized by retrograde cyclic motor patterns on high-resolution colonic manometry has been postulated as a contributor to the maintenance of bowel continence. Sacral neuromodulation (SNM) is an effective therapy for faecal incontinence, but its mechanism of action is unclear. This study aims to investigate the colonic motility patterns in the distal colon of patients with faecal incontinence, and how these are modulated by SNM. Methods: A high-resolution fibre-optic colonic manometry catheter, containing 36 sensors spaced at 1-cm intervals, was positioned in patients with faecal incontinence undergoing Stage 1 SNM. One hour of pre-meal and post-meal recordings were obtained followed by pre- and post-meal recordings with suprasensory SNM. A 700-kcal meal was given. Data were analysed to identify propagating contractions. Results: Fifteen patients with faecal incontinence were analysed. Patients had an abnormal meal response (fewer retrograde propagating contractions compared to controls; p=0.027) and failed to show a postmeal increase in propagating contractions (mean 17 +/- 6/h pre-meal vs 22 +/- 9/h post-meal, p = 0.438). Compared to baseline, SNM significantly increased the number of retrograde propagating contractions in the distal colon (8 +/- 3/h pre-meal vs 14 +/- 3/h pre-meal with SNM, p = 0.028). Consuming a meal did not further increase the number of propagating contractions beyond the baseline upregulating effect of SNM. Conclusion: The rectosigmoid brake was suppressed in this cohort of patients with faecal incontinence. SNM may exert a therapeutic effect by modulating this rectosigmoid brake." @default.
- W3217221444 created "2021-12-06" @default.
- W3217221444 creator A5000581854 @default.
- W3217221444 creator A5018212696 @default.
- W3217221444 creator A5021506723 @default.
- W3217221444 creator A5031958340 @default.
- W3217221444 creator A5039076247 @default.
- W3217221444 creator A5053277333 @default.
- W3217221444 creator A5076032906 @default.
- W3217221444 creator A5082961579 @default.
- W3217221444 date "2021-12-02" @default.
- W3217221444 modified "2023-10-17" @default.
- W3217221444 title "Faecal incontinence is associated with an impaired rectosigmoid brake and improved by sacral neuromodulation" @default.
- W3217221444 cites W1487696982 @default.
- W3217221444 cites W1668885871 @default.
- W3217221444 cites W1895501895 @default.
- W3217221444 cites W1975664399 @default.
- W3217221444 cites W1977240909 @default.
- W3217221444 cites W1985949625 @default.
- W3217221444 cites W1986422164 @default.
- W3217221444 cites W1987603660 @default.
- W3217221444 cites W1993275171 @default.
- W3217221444 cites W2002599909 @default.
- W3217221444 cites W2006721040 @default.
- W3217221444 cites W2019217335 @default.
- W3217221444 cites W2025917924 @default.
- W3217221444 cites W2028088566 @default.
- W3217221444 cites W2032552897 @default.
- W3217221444 cites W2042834504 @default.
- W3217221444 cites W2060658682 @default.
- W3217221444 cites W2073248260 @default.
- W3217221444 cites W2078406145 @default.
- W3217221444 cites W2107720245 @default.
- W3217221444 cites W2117300470 @default.
- W3217221444 cites W2125390509 @default.
- W3217221444 cites W2148360412 @default.
- W3217221444 cites W2152852254 @default.
- W3217221444 cites W2167468463 @default.
- W3217221444 cites W2324348422 @default.
- W3217221444 cites W2333269694 @default.
- W3217221444 cites W2419427347 @default.
- W3217221444 cites W2528347737 @default.
- W3217221444 cites W2802920109 @default.
- W3217221444 cites W2897586315 @default.
- W3217221444 cites W3108226978 @default.
- W3217221444 cites W3165460212 @default.
- W3217221444 cites W3202068022 @default.
- W3217221444 cites W95841808 @default.
- W3217221444 doi "https://doi.org/10.1101/2021.11.30.21266844" @default.
- W3217221444 hasPublicationYear "2021" @default.
- W3217221444 type Work @default.
- W3217221444 sameAs 3217221444 @default.
- W3217221444 citedByCount "0" @default.
- W3217221444 crossrefType "posted-content" @default.
- W3217221444 hasAuthorship W3217221444A5000581854 @default.
- W3217221444 hasAuthorship W3217221444A5018212696 @default.
- W3217221444 hasAuthorship W3217221444A5021506723 @default.
- W3217221444 hasAuthorship W3217221444A5031958340 @default.
- W3217221444 hasAuthorship W3217221444A5039076247 @default.
- W3217221444 hasAuthorship W3217221444A5053277333 @default.
- W3217221444 hasAuthorship W3217221444A5076032906 @default.
- W3217221444 hasAuthorship W3217221444A5082961579 @default.
- W3217221444 hasBestOaLocation W32172214441 @default.
- W3217221444 hasConcept C126322002 @default.
- W3217221444 hasConcept C126894567 @default.
- W3217221444 hasConcept C24998067 @default.
- W3217221444 hasConcept C2778345441 @default.
- W3217221444 hasConcept C2780375056 @default.
- W3217221444 hasConcept C71924100 @default.
- W3217221444 hasConcept C90924648 @default.
- W3217221444 hasConceptScore W3217221444C126322002 @default.
- W3217221444 hasConceptScore W3217221444C126894567 @default.
- W3217221444 hasConceptScore W3217221444C24998067 @default.
- W3217221444 hasConceptScore W3217221444C2778345441 @default.
- W3217221444 hasConceptScore W3217221444C2780375056 @default.
- W3217221444 hasConceptScore W3217221444C71924100 @default.
- W3217221444 hasConceptScore W3217221444C90924648 @default.
- W3217221444 hasLocation W32172214441 @default.
- W3217221444 hasOpenAccess W3217221444 @default.
- W3217221444 hasPrimaryLocation W32172214441 @default.
- W3217221444 hasRelatedWork W1986199235 @default.
- W3217221444 hasRelatedWork W2033525850 @default.
- W3217221444 hasRelatedWork W2057208631 @default.
- W3217221444 hasRelatedWork W2071668753 @default.
- W3217221444 hasRelatedWork W2111056386 @default.
- W3217221444 hasRelatedWork W2148656812 @default.
- W3217221444 hasRelatedWork W2151556292 @default.
- W3217221444 hasRelatedWork W2171655093 @default.
- W3217221444 hasRelatedWork W2392413698 @default.
- W3217221444 hasRelatedWork W2118673085 @default.
- W3217221444 isParatext "false" @default.
- W3217221444 isRetracted "false" @default.
- W3217221444 magId "3217221444" @default.
- W3217221444 workType "article" @default.