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- W3217239675 endingPage "1419.e6" @default.
- W3217239675 startingPage "1394" @default.
- W3217239675 abstract "Hookworms are hematophagous nematode parasites that have infected a billion people worldwide. Anthelmintic drugs have limited efficacy and do not prevent reinfection. Therefore, prophylactic vaccines are in high demand. Whole parasite vaccines are allergic and unsafe; thus, research into subunit vaccines has been warranted. A comprehensive overview of protein or peptide subunit vaccines' safety, protective efficacy, and associated immune responses is provided herein. The differences between the immune responses against hookworm infection by patients from epidemic versus nonepidemic areas are discussed in detail. Moreover, the different immunologic mechanisms of protection are discussed, including those that rely on allergic and nonallergic humoral and antibody-dependent cellular responses. The allergic and autoimmune potential of hookworm antigens is also explored, as are the immunoregulatory responses induced by the hookworm secretome. The potential of oral mucosal immunizations has been overlooked. Oral immunity against hookworms is a long-lived and safer immune response that is associated with elimination of infection and protective against reinfections. However, the harsh conditions of the gastrointestinal environment necessitates special oral delivery systems to unlock vaccines' protective potential. The potential for development of safer and more effective peptide- and protein-based anthelmintic vaccines is explored herein." @default.
- W3217239675 created "2021-12-06" @default.
- W3217239675 creator A5008581557 @default.
- W3217239675 creator A5028490375 @default.
- W3217239675 creator A5051605057 @default.
- W3217239675 creator A5086825190 @default.
- W3217239675 date "2021-12-01" @default.
- W3217239675 modified "2023-10-13" @default.
- W3217239675 title "Hookworm infection: Toward development of safe and effective peptide vaccines" @default.
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