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- W3217249110 endingPage "5812" @default.
- W3217249110 startingPage "5812" @default.
- W3217249110 abstract "Mitochondria constitute an ever-reorganizing dynamic network that plays a key role in several fundamental cellular functions, including the regulation of metabolism, energy production, calcium homeostasis, production of reactive oxygen species, and programmed cell death. Each of these activities can be found to be impaired in cancer cells. It has been reported that mitochondrial dynamics are actively involved in both tumorigenesis and metabolic plasticity, allowing cancer cells to adapt to unfavorable environmental conditions and, thus, contributing to tumor progression. The mitochondrial dynamics include fusion, fragmentation, intracellular trafficking responsible for redistributing the organelle within the cell, biogenesis, and mitophagy. Although the mitochondrial dynamics are driven by the cytoskeleton-particularly by the microtubules and the microtubule-associated motor proteins dynein and kinesin-the molecular mechanisms regulating these complex processes are not yet fully understood. More recently, an exchange of mitochondria between stromal and cancer cells has also been described. The advantage of mitochondrial transfer in tumor cells results in benefits to cell survival, proliferation, and spreading. Therefore, understanding the molecular mechanisms that regulate mitochondrial trafficking can potentially be important for identifying new molecular targets in cancer therapy to interfere specifically with tumor dissemination processes." @default.
- W3217249110 created "2021-12-06" @default.
- W3217249110 creator A5005017125 @default.
- W3217249110 creator A5021070443 @default.
- W3217249110 creator A5062137970 @default.
- W3217249110 date "2021-11-19" @default.
- W3217249110 modified "2023-10-18" @default.
- W3217249110 title "Microtubule-Based Mitochondrial Dynamics as a Valuable Therapeutic Target in Cancer" @default.
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