FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217264326> ?p ?o ?g. }

• W3217264326 endingPage "S11" @default.
• W3217264326 startingPage "S11" @default.
• W3217264326 abstract "BackgroundSurgery is the main modality of cure for solid cancers and was prioritised to continue during SARS-CoV-2 outbreaks. This study aimed to identify areas for health system strengthening by comparing the delivery of elective cancer surgery during COVID-19 in periods of lockdown versus light restriction.MethodsIn this international, multicentre, prospective cohort study, we enrolled patients with 15 cancer types who had a decision for surgery during the SARS-CoV-2 pandemic (between Jan 21, 2020 and April 14, 2020) to Aug 31, 2020. Any hospital worldwide providing elective cancer surgery was eligible. The primary outcome was the non-operation rate (proportion of patients who did not undergo planned surgery). Reasons for non-operation were classified as COVID-19 related (societal, operational, or personal) or unrelated. Average national Oxford COVID-19 Stringency Index scores were calculated for each patient during their wait for surgery and classified into light restrictions (index <20), moderate lockdowns (20–60), and full lockdowns (>60). Cox proportional-hazards regression models were used to explore associations between lockdowns and non-operation. This study was registered at ClinicalTrials.gov, NCT04384926.FindingsWe enrolled 27 700 participants, of whom 20 006 patients (8526 men and 11480 women) from 466 hospitals and 61 countries did not receive surgery after a minimum of 3-months' follow up (median 23 weeks [IQR 16–30]). All patients had a COVID-19-related reason for non-operation. Light restrictions were associated with a 0·6% reference non-operation rate, moderate lockdowns with a 5·5% rate (HR 0·81, 95% CI 0·77–0·84, p<0·0001), and full lockdowns with a 15·0% rate (0·51, 0·50– 0·53, p<0·0001). In sensitivity analyses, including adjustment for SARS-COV-2 case notification rates, moderate (0·84, 0·80–0·88; p<0·001), and full lockdowns (0·57, 0·54–0·60; p<0·001) remained independently associated with non-operation. Frail patients with advanced cancer, particularly those from low-income and middle-income countries and those requiring postoperative critical care, were more likely to not have an operation.InterpretationCancer surgery systems worldwide were affected by lockdowns, including in the UK, with one in seven patients not undergoing planned surgery. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which could include protected elective surgical pathways and long-term investment in surge capacity for acute care during public health emergencies. In the UK, a whole-health system approach is required to mitigate against further harm for NHS patients.FundingNational Institute for Health Research (NIHR) Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, Economic and Social Research Council, European Society of Coloproctology, Medtronic, NIHR Academy, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research." @default.
• W3217264326 created "2021-12-06" @default.
• W3217264326 creator A5072254735 @default.
• W3217264326 date "2021-11-01" @default.
• W3217264326 modified "2023-10-17" @default.
• W3217264326 title "Resilience of elective cancer surgery systems during COVID-19 lockdowns: an international, multicentre, prospective cohort study" @default.
• W3217264326 doi "https://doi.org/10.1016/s0140-6736(21)02554-x" @default.
• W3217264326 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8617314" @default.
• W3217264326 hasPublicationYear "2021" @default.
• W3217264326 type Work @default.
• W3217264326 sameAs 3217264326 @default.
• W3217264326 citedByCount "1" @default.
• W3217264326 countsByYear W32172643262022 @default.
• W3217264326 crossrefType "journal-article" @default.
• W3217264326 hasAuthorship W3217264326A5072254735 @default.
• W3217264326 hasBestOaLocation W32172643261 @default.
• W3217264326 hasConcept C121608353 @default.
• W3217264326 hasConcept C126322002 @default.
• W3217264326 hasConcept C141071460 @default.
• W3217264326 hasConcept C188816634 @default.
• W3217264326 hasConcept C194828623 @default.
• W3217264326 hasConcept C201903717 @default.
• W3217264326 hasConcept C2779134260 @default.
• W3217264326 hasConcept C2781312054 @default.
• W3217264326 hasConcept C2992687050 @default.
• W3217264326 hasConcept C3008058167 @default.
• W3217264326 hasConcept C50382708 @default.
• W3217264326 hasConcept C524204448 @default.
• W3217264326 hasConcept C71924100 @default.
• W3217264326 hasConcept C72563966 @default.
• W3217264326 hasConceptScore W3217264326C121608353 @default.
• W3217264326 hasConceptScore W3217264326C126322002 @default.
• W3217264326 hasConceptScore W3217264326C141071460 @default.
• W3217264326 hasConceptScore W3217264326C188816634 @default.
• W3217264326 hasConceptScore W3217264326C194828623 @default.
• W3217264326 hasConceptScore W3217264326C201903717 @default.
• W3217264326 hasConceptScore W3217264326C2779134260 @default.
• W3217264326 hasConceptScore W3217264326C2781312054 @default.
• W3217264326 hasConceptScore W3217264326C2992687050 @default.
• W3217264326 hasConceptScore W3217264326C3008058167 @default.
• W3217264326 hasConceptScore W3217264326C50382708 @default.
• W3217264326 hasConceptScore W3217264326C524204448 @default.
• W3217264326 hasConceptScore W3217264326C71924100 @default.
• W3217264326 hasConceptScore W3217264326C72563966 @default.
• W3217264326 hasLocation W32172643261 @default.
• W3217264326 hasLocation W32172643262 @default.
• W3217264326 hasLocation W32172643263 @default.
• W3217264326 hasOpenAccess W3217264326 @default.
• W3217264326 hasPrimaryLocation W32172643261 @default.
• W3217264326 hasRelatedWork W2031086945 @default.
• W3217264326 hasRelatedWork W2042664817 @default.
• W3217264326 hasRelatedWork W2750095015 @default.
• W3217264326 hasRelatedWork W2912705052 @default.
• W3217264326 hasRelatedWork W2987985474 @default.
• W3217264326 hasRelatedWork W3116131585 @default.
• W3217264326 hasRelatedWork W3176033318 @default.
• W3217264326 hasRelatedWork W4254169278 @default.
• W3217264326 hasRelatedWork W4281965648 @default.
• W3217264326 hasRelatedWork W4226344455 @default.
• W3217264326 hasVolume "398" @default.
• W3217264326 isParatext "false" @default.
• W3217264326 isRetracted "false" @default.
• W3217264326 magId "3217264326" @default.
• W3217264326 workType "article" @default.