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- W3217284731 abstract "The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5-year overall survival for CMR, MRDnq and MRDq at week 11 was 74·0%, 42·3% and 35·0% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0·32 and 2·25)." @default.
- W3217284731 created "2021-12-06" @default.
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- W3217284731 date "2021-11-23" @default.
- W3217284731 modified "2023-09-26" @default.
- W3217284731 title "Low levels of minimal residual disease after induction chemotherapy for BCR‐ABL1 ‐negative acute lymphoblastic leukaemia in adults are clinically relevant" @default.
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- W3217284731 doi "https://doi.org/10.1111/bjh.17966" @default.
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