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- W3217291208 abstract "Primary hyperoxalurias (PHs) are rare genetic disorders that cause hyperproduction of oxalate in the liver. The clinical manifestations of excess oxalate include urolithiasis, nephrocalcinosis, and end-stage renal disease. The onset of renal failure—which typically represents a turning point in the course of PHs—results in the inability to remove oxalate in the urine. This in turn leads to a progressive accumulation of insoluble calcium-oxalate (Ca-Ox) crystals in various tissues. This severe condition, termed systemic oxalosis (SO),1 has an unfavorable prognosis characterized by persistent pain, increased vulnerability to fractures,2 and significant mortality." @default.
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- W3217291208 date "2022-02-01" @default.
- W3217291208 modified "2023-10-16" @default.
- W3217291208 title "Granulomatous Inflammation and Hypercalcemia in Patients With Severe Systemic Oxalosis" @default.
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- W3217291208 doi "https://doi.org/10.1016/j.ekir.2021.11.020" @default.
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