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- W3217296584 endingPage "204173142110605" @default.
- W3217296584 startingPage "204173142110605" @default.
- W3217296584 abstract "In modern life, several factors such as genetics, exposure to toxins, and aging have resulted in significant levels of male infertility, estimated to be approximately 18% worldwide. In response, substantial progress has been made to improve in vitro fertilization treatments (e.g. microsurgical testicular sperm extraction (m-TESE), intra-cytoplasmic sperm injection (ICSI), and round spermatid injection (ROSI)). Mimicking the structure of testicular natural extracellular matrices (ECM) outside of the body is one clear route toward complete in vitro spermatogenesis and male fertility preservation. Here, a new wave of technological innovations is underway applying regenerative medicine strategies to cell-tissue culture on natural or synthetic scaffolds supplemented with bioactive factors. The emergence of advanced bioengineered systems suggests new hope for male fertility preservation through development of functional male germ cells. To date, few studies aimed at in vitro spermatogenesis have resulted in relevant numbers of mature gametes. However, a substantial body of knowledge on conditions that are required to maintain and mature male germ cells in vitro is now in place. This review focuses on advanced bioengineering methods such as microfluidic systems, bio-fabricated scaffolds, and 3D organ culture applied to the germline for fertility preservation through in vitro spermatogenesis." @default.
- W3217296584 created "2021-12-06" @default.
- W3217296584 creator A5002403527 @default.
- W3217296584 creator A5010510822 @default.
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- W3217296584 creator A5053090647 @default.
- W3217296584 creator A5065858331 @default.
- W3217296584 creator A5082367236 @default.
- W3217296584 date "2021-01-01" @default.
- W3217296584 modified "2023-10-18" @default.
- W3217296584 title "Advanced bioengineering of male germ stem cells to preserve fertility" @default.
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