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- W3217355299 endingPage "162" @default.
- W3217355299 startingPage "111" @default.
- W3217355299 abstract "Statins, otherwise known as 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are a pharmacological class of medication frequently utilized in the treatment of dyslipidemia. These agents have shown some promise in preclinical and early phase trials for neuroprotection after acute neurological injury. While the primary mechanism of action of statins is inhibition of the HMG-CoA enzyme, the rate-limiting enzyme in cholesterol synthesis, resulting in an increased expression of low-density lipoprotein (LDL) receptors and ultimately a reduction in serum LDL, statins have been reported to have several pleiotropic effects including improvement in endothelial function, reducing inflammation, inhibition of platelet aggregation, and anticoagulant properties. This chapter describes the available evidence to date examining statin pharmacotherapy for neuroprotection after traumatic brain injury, acute ischemic stroke, intracerebral hemorrhage, and aneurysmal subarachnoid hemorrhage." @default.
- W3217355299 created "2021-12-06" @default.
- W3217355299 creator A5009723834 @default.
- W3217355299 creator A5010468780 @default.
- W3217355299 creator A5044158756 @default.
- W3217355299 creator A5047982417 @default.
- W3217355299 date "2022-01-01" @default.
- W3217355299 modified "2023-10-13" @default.
- W3217355299 title "Role of statins for neuroprotection" @default.
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