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- W3217362012 abstract "<b>Introduction:</b> The impact of comorbidities in patients with unclassifiable interstitial lung disease (uILD) is sparsely studied. We aimed to describe clusters of comorbidities in uILD and their prognosis. <b>Methods:</b> uILD patients from 2 ILD centers (Aarhus, Denmark; Heidelberg, Germany) were identified and 20 prespecified comorbidities were registered. Self-organizing maps were used to compute clusters of comorbidities. Kaplan-Meier survival estimates and the log-rank test was used for survival estimates. <b>Results:</b> In total, 249 uILD patients were identified (median age 70, 60% male, FVC 76%, DLCO 50%). Three clusters were observed in the Aarhus cohort (143 patients) and verified in the Heidelberg cohort (106 patients): Few comorbidities (FC), cardiovascular (CV) and emphysema (EM) (Figure 1). Patients in the FC cluster were younger, while patients in the CV cluster were older, former smokers, had cardiac and cerebrovascular disease, arterial hypertension, chronic renal failure, sleep apnea and thyroid disease. In the EM cluster, emphysema, pulmonary hypertension, osteoporosis, reflux disease and current smoking were prevalent. Two-year survival in the FC, CV and EM clusters was 82%, 74% and 73%, respectively, p = 0.41. <b>Conclusion:</b> Three distinct comorbidities clusters were identified in uILD patients. These clusters could represent phenotypes in uILD, but no mortality difference was observed, possibly due to a limited median follow-up time of 1.4 years." @default.
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- W3217362012 date "2021-09-05" @default.
- W3217362012 modified "2023-10-18" @default.
- W3217362012 title "Clusters of comorbidities in unclassifiable interstitial lung disease" @default.
- W3217362012 doi "https://doi.org/10.1183/13993003.congress-2021.pa3744" @default.
- W3217362012 hasPublicationYear "2021" @default.
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