Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217365775> ?p ?o ?g. }
- W3217365775 abstract "Men are more vulnerable to ischemic heart disease (IHD) than women, possibly due to testosterone. Correspondingly, sex hormone binding globulin (SHBG) which lowers circulating testosterone might protect men against IHD. SHBG may also affect IHD independent of testosterone, which has not previously been examined. To assess the sex-specific role of SHBG in IHD, in univariable Mendelian randomization (MR), we used sex-specific, genome-wide significant genetic variants to predict SHBG, and examined their association with IHD in the UK Biobank. We also replicated using genetic instruments from Japanese men and applied to Biobank Japan. To assess the role of SHGB independent of testosterone in men, we used multivariable MR controlling for testosterone. Genetically predicted SHBG was associated with lower IHD risk in men [odds ratio (OR) 0.78 per standard deviation, 95% confidence interval (CI) 0.70 to 0.87], and the association was less clear in women. The estimates were similar in Japanese. The inverse association remained after controlling for testosterone in men (OR 0.79, 95% CI 0.71 to 0.88). SHBG might lower the risk of IHD in men, with a role independent of testosterone. Exploring intervention strategies that increase SHBG is important for targeting IHD treatments." @default.
- W3217365775 created "2021-12-06" @default.
- W3217365775 creator A5036765539 @default.
- W3217365775 creator A5073476241 @default.
- W3217365775 date "2021-11-30" @default.
- W3217365775 modified "2023-10-18" @default.
- W3217365775 title "Genetically predicted sex hormone binding globulin and ischemic heart disease in men and women: a univariable and multivariable Mendelian randomization study" @default.
- W3217365775 cites W1532668077 @default.
- W3217365775 cites W1966222552 @default.
- W3217365775 cites W1972696558 @default.
- W3217365775 cites W2020703194 @default.
- W3217365775 cites W2032054176 @default.
- W3217365775 cites W2058072718 @default.
- W3217365775 cites W2078601979 @default.
- W3217365775 cites W2078773383 @default.
- W3217365775 cites W2082704080 @default.
- W3217365775 cites W2096913799 @default.
- W3217365775 cites W2101969517 @default.
- W3217365775 cites W2104334596 @default.
- W3217365775 cites W2108038333 @default.
- W3217365775 cites W2110318301 @default.
- W3217365775 cites W2111986533 @default.
- W3217365775 cites W2115042465 @default.
- W3217365775 cites W2129465958 @default.
- W3217365775 cites W2134471459 @default.
- W3217365775 cites W2139109527 @default.
- W3217365775 cites W2153117775 @default.
- W3217365775 cites W2153662687 @default.
- W3217365775 cites W2155533485 @default.
- W3217365775 cites W2169283889 @default.
- W3217365775 cites W2267003776 @default.
- W3217365775 cites W2324862792 @default.
- W3217365775 cites W2508534964 @default.
- W3217365775 cites W2519131377 @default.
- W3217365775 cites W2520048741 @default.
- W3217365775 cites W2528736623 @default.
- W3217365775 cites W2598625467 @default.
- W3217365775 cites W2613603864 @default.
- W3217365775 cites W2614566443 @default.
- W3217365775 cites W2742117056 @default.
- W3217365775 cites W2804870223 @default.
- W3217365775 cites W2805138198 @default.
- W3217365775 cites W2810907329 @default.
- W3217365775 cites W2818417770 @default.
- W3217365775 cites W2894314149 @default.
- W3217365775 cites W2903864664 @default.
- W3217365775 cites W2947726802 @default.
- W3217365775 cites W2949275660 @default.
- W3217365775 cites W2965936699 @default.
- W3217365775 cites W2971615841 @default.
- W3217365775 cites W2981338841 @default.
- W3217365775 cites W3004892753 @default.
- W3217365775 cites W3005295566 @default.
- W3217365775 cites W3013387105 @default.
- W3217365775 cites W3014191903 @default.
- W3217365775 cites W3029123921 @default.
- W3217365775 cites W3029417068 @default.
- W3217365775 cites W3033304694 @default.
- W3217365775 cites W3057302762 @default.
- W3217365775 cites W3080182863 @default.
- W3217365775 cites W3080355783 @default.
- W3217365775 cites W3088670731 @default.
- W3217365775 cites W3093213013 @default.
- W3217365775 cites W3111198503 @default.
- W3217365775 cites W3122256196 @default.
- W3217365775 cites W3157971051 @default.
- W3217365775 cites W3177112013 @default.
- W3217365775 cites W4210703904 @default.
- W3217365775 cites W4242554181 @default.
- W3217365775 cites W4252406137 @default.
- W3217365775 doi "https://doi.org/10.1038/s41598-021-02510-w" @default.
- W3217365775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8632960" @default.
- W3217365775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34848757" @default.
- W3217365775 hasPublicationYear "2021" @default.
- W3217365775 type Work @default.
- W3217365775 sameAs 3217365775 @default.
- W3217365775 citedByCount "6" @default.
- W3217365775 countsByYear W32173657752023 @default.
- W3217365775 crossrefType "journal-article" @default.
- W3217365775 hasAuthorship W3217365775A5036765539 @default.
- W3217365775 hasAuthorship W3217365775A5073476241 @default.
- W3217365775 hasBestOaLocation W32173657751 @default.
- W3217365775 hasConcept C104317684 @default.
- W3217365775 hasConcept C106208931 @default.
- W3217365775 hasConcept C126322002 @default.
- W3217365775 hasConcept C134018914 @default.
- W3217365775 hasConcept C135763542 @default.
- W3217365775 hasConcept C153209595 @default.
- W3217365775 hasConcept C156957248 @default.
- W3217365775 hasConcept C2777911890 @default.
- W3217365775 hasConcept C2779134260 @default.
- W3217365775 hasConcept C2779279991 @default.
- W3217365775 hasConcept C2779901538 @default.
- W3217365775 hasConcept C2993967602 @default.
- W3217365775 hasConcept C30092816 @default.
- W3217365775 hasConcept C42407357 @default.
- W3217365775 hasConcept C44249647 @default.
- W3217365775 hasConcept C54355233 @default.
- W3217365775 hasConcept C71315377 @default.
- W3217365775 hasConcept C71924100 @default.