Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217379353> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3217379353 endingPage "vi138" @default.
- W3217379353 startingPage "vi138" @default.
- W3217379353 abstract "Abstract The current study tested the hypotheses that (1) pH-weighted MRI measurements of tumor acidity reflect glycolytic activity in human gliomas, (2) that tumor acidity, and thus glycolytic activity, differs between human IDH mutant (mIDH) and wild type gliomas, and (3) that an increase in tumor acidity, suggestive of increased glycolytic activity, occurs after inhibition of mutant IDH enzyme activity and reduction in 2HG, an oncometabolite. To test these hypotheses, we employed a custom pH-weighted amine chemical exchange saturation transfer echoplanar (CEST-EPI) technique in 152 patients with IDH mutant or wildtype glioma prior to surgery and 11 patients before and after treatment with AG120 or AG881 enrolled at our institution in a phase 1 perioperative study in patients with recurrent, non-enhancing, IDH mutant low-grade gliomas (NCT03343197). Results from image-guided biopsies in more than 100 patients demonstrated a significant correlation between MTRasym at 3ppm, a measure of tumor acidity from pH-weighted amine CEST-EPI, and expression of key glycolytic proteins including GLUT3 (R2=0.2188,P=0.0105), HK2 (R2=0.1788,P=0.0314), LDHA (R2=0.1111,P=0.0071), and MCT1 (R2=0.1228,P=0.0039) as well as ex vivo extracellular flux analysis estimates of ATP consumption from glycolysis (R2=0.6684,P=0.0021). Data suggests a significantly lower acidity (MTRasym@3ppm) within non-enhancing tumor in IDH mutant gliomas when compared to IDH wild type gliomas (P< 0.0001). Patients in a phase 1 perioperative study showed a shift toward higher tumor acidity (i.e. higher glycolytic activity) following inhibition of IDH based on 2HG suppression in resected tumors, but at levels below that of IDH wild type gliomas. Levels of 2HG within the tumor after IDH inhibition were inversely correlated with post-treatment tumor acidity (R2=0.6342, P=0.0180). Overall, results suggest mIDH gliomas have low levels of glycolytic activity, and successful inhibition of the mutant IDH enzyme results in reduction in 2HG and a measurable metabolic shift toward elevated glycolysis as evidenced using pH-weighted molecular MRI." @default.
- W3217379353 created "2021-12-06" @default.
- W3217379353 creator A5002744472 @default.
- W3217379353 creator A5009012019 @default.
- W3217379353 creator A5009485093 @default.
- W3217379353 creator A5012475223 @default.
- W3217379353 creator A5013892365 @default.
- W3217379353 creator A5017671349 @default.
- W3217379353 creator A5019281368 @default.
- W3217379353 creator A5019669804 @default.
- W3217379353 creator A5025351354 @default.
- W3217379353 creator A5030410351 @default.
- W3217379353 creator A5038569402 @default.
- W3217379353 creator A5041483225 @default.
- W3217379353 creator A5046758575 @default.
- W3217379353 creator A5072005094 @default.
- W3217379353 creator A5077230063 @default.
- W3217379353 creator A5079316205 @default.
- W3217379353 creator A5084168615 @default.
- W3217379353 creator A5086009314 @default.
- W3217379353 date "2021-11-02" @default.
- W3217379353 modified "2023-10-15" @default.
- W3217379353 title "NIMG-41. PH-WEIGHTED MOLECULAR MRI AS AN EARLY BIOMARKER OF METABOLIC RESPONSE TO IDH INHIBITION IN IDH MUTANT GLIOMAS" @default.
- W3217379353 doi "https://doi.org/10.1093/neuonc/noab196.540" @default.
- W3217379353 hasPublicationYear "2021" @default.
- W3217379353 type Work @default.
- W3217379353 sameAs 3217379353 @default.
- W3217379353 citedByCount "0" @default.
- W3217379353 crossrefType "journal-article" @default.
- W3217379353 hasAuthorship W3217379353A5002744472 @default.
- W3217379353 hasAuthorship W3217379353A5009012019 @default.
- W3217379353 hasAuthorship W3217379353A5009485093 @default.
- W3217379353 hasAuthorship W3217379353A5012475223 @default.
- W3217379353 hasAuthorship W3217379353A5013892365 @default.
- W3217379353 hasAuthorship W3217379353A5017671349 @default.
- W3217379353 hasAuthorship W3217379353A5019281368 @default.
- W3217379353 hasAuthorship W3217379353A5019669804 @default.
- W3217379353 hasAuthorship W3217379353A5025351354 @default.
- W3217379353 hasAuthorship W3217379353A5030410351 @default.
- W3217379353 hasAuthorship W3217379353A5038569402 @default.
- W3217379353 hasAuthorship W3217379353A5041483225 @default.
- W3217379353 hasAuthorship W3217379353A5046758575 @default.
- W3217379353 hasAuthorship W3217379353A5072005094 @default.
- W3217379353 hasAuthorship W3217379353A5077230063 @default.
- W3217379353 hasAuthorship W3217379353A5079316205 @default.
- W3217379353 hasAuthorship W3217379353A5084168615 @default.
- W3217379353 hasAuthorship W3217379353A5086009314 @default.
- W3217379353 hasBestOaLocation W32173793531 @default.
- W3217379353 hasConcept C104317684 @default.
- W3217379353 hasConcept C126322002 @default.
- W3217379353 hasConcept C143065580 @default.
- W3217379353 hasConcept C181199279 @default.
- W3217379353 hasConcept C185592680 @default.
- W3217379353 hasConcept C20251656 @default.
- W3217379353 hasConcept C207583985 @default.
- W3217379353 hasConcept C2778227246 @default.
- W3217379353 hasConcept C2781197716 @default.
- W3217379353 hasConcept C28406088 @default.
- W3217379353 hasConcept C502942594 @default.
- W3217379353 hasConcept C55493867 @default.
- W3217379353 hasConcept C71924100 @default.
- W3217379353 hasConcept C86803240 @default.
- W3217379353 hasConceptScore W3217379353C104317684 @default.
- W3217379353 hasConceptScore W3217379353C126322002 @default.
- W3217379353 hasConceptScore W3217379353C143065580 @default.
- W3217379353 hasConceptScore W3217379353C181199279 @default.
- W3217379353 hasConceptScore W3217379353C185592680 @default.
- W3217379353 hasConceptScore W3217379353C20251656 @default.
- W3217379353 hasConceptScore W3217379353C207583985 @default.
- W3217379353 hasConceptScore W3217379353C2778227246 @default.
- W3217379353 hasConceptScore W3217379353C2781197716 @default.
- W3217379353 hasConceptScore W3217379353C28406088 @default.
- W3217379353 hasConceptScore W3217379353C502942594 @default.
- W3217379353 hasConceptScore W3217379353C55493867 @default.
- W3217379353 hasConceptScore W3217379353C71924100 @default.
- W3217379353 hasConceptScore W3217379353C86803240 @default.
- W3217379353 hasIssue "Supplement_6" @default.
- W3217379353 hasLocation W32173793531 @default.
- W3217379353 hasOpenAccess W3217379353 @default.
- W3217379353 hasPrimaryLocation W32173793531 @default.
- W3217379353 hasRelatedWork W1921927879 @default.
- W3217379353 hasRelatedWork W2009344637 @default.
- W3217379353 hasRelatedWork W2061099251 @default.
- W3217379353 hasRelatedWork W2127276750 @default.
- W3217379353 hasRelatedWork W2168276823 @default.
- W3217379353 hasRelatedWork W2345878551 @default.
- W3217379353 hasRelatedWork W3048089101 @default.
- W3217379353 hasRelatedWork W4213030096 @default.
- W3217379353 hasRelatedWork W4246662077 @default.
- W3217379353 hasRelatedWork W214510971 @default.
- W3217379353 hasVolume "23" @default.
- W3217379353 isParatext "false" @default.
- W3217379353 isRetracted "false" @default.
- W3217379353 magId "3217379353" @default.
- W3217379353 workType "article" @default.