FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217387659> ?p ?o ?g. }

• W3217387659 abstract "Gene co-expression networks (GCNs) provide multiple benefits to molecular research including hypothesis generation and biomarker discovery. Transcriptome profiles serve as input for GCN construction and are derived from increasingly larger studies with samples across multiple experimental conditions, treatments, time points, genotypes, etc. Such experiments with larger numbers of variables confound discovery of true network edges, exclude edges and inhibit discovery of context (or condition) specific network edges. To demonstrate this problem, a 475-sample dataset is used to show that up to 97% of GCN edges can be misleading because correlations are false or incorrect. False and incorrect correlations can occur when tests are applied without ensuring assumptions are met, and pairwise gene expression may not meet test assumptions if the expression of at least one gene in the pairwise comparison is a function of multiple confounding variables. The 'one-size-fits-all' approach to GCN construction is therefore problematic for large, multivariable datasets. Recently, the Knowledge Independent Network Construction toolkit has been used in multiple studies to provide a dynamic approach to GCN construction that ensures statistical tests meet assumptions and confounding variables are addressed. Additionally, it can associate experimental context for each edge of the network resulting in context-specific GCNs (csGCNs). To help researchers recognize such challenges in GCN construction, and the creation of csGCNs, we provide a review of the workflow." @default.
• W3217387659 created "2021-12-06" @default.
• W3217387659 creator A5003436355 @default.
• W3217387659 creator A5015114586 @default.
• W3217387659 creator A5021360029 @default.
• W3217387659 creator A5037779471 @default.
• W3217387659 creator A5041599600 @default.
• W3217387659 creator A5043923029 @default.
• W3217387659 creator A5045232150 @default.
• W3217387659 creator A5059972300 @default.
• W3217387659 creator A5083665803 @default.
• W3217387659 date "2021-11-30" @default.
• W3217387659 modified "2023-10-11" @default.
• W3217387659 title "Addressing noise in co-expression network construction" @default.
• W3217387659 cites W1891041548 @default.
• W3217387659 cites W1973651601 @default.
• W3217387659 cites W1986849266 @default.
• W3217387659 cites W2003456502 @default.
• W3217387659 cites W2006810478 @default.
• W3217387659 cites W2014731896 @default.
• W3217387659 cites W2015968355 @default.
• W3217387659 cites W2021164824 @default.
• W3217387659 cites W2024467994 @default.
• W3217387659 cites W2030813272 @default.
• W3217387659 cites W2034784092 @default.
• W3217387659 cites W2043701535 @default.
• W3217387659 cites W2044525257 @default.
• W3217387659 cites W2044692345 @default.
• W3217387659 cites W2047311093 @default.
• W3217387659 cites W2060705109 @default.
• W3217387659 cites W2072103747 @default.
• W3217387659 cites W2079574756 @default.
• W3217387659 cites W2094238140 @default.
• W3217387659 cites W2102043440 @default.
• W3217387659 cites W2104724027 @default.
• W3217387659 cites W2115111790 @default.
• W3217387659 cites W2116041602 @default.
• W3217387659 cites W2118258530 @default.
• W3217387659 cites W2121695897 @default.
• W3217387659 cites W2122982115 @default.
• W3217387659 cites W2123828448 @default.
• W3217387659 cites W2124088880 @default.
• W3217387659 cites W2125118217 @default.
• W3217387659 cites W2130116522 @default.
• W3217387659 cites W2133254377 @default.
• W3217387659 cites W2142720308 @default.
• W3217387659 cites W2147649238 @default.
• W3217387659 cites W2150646520 @default.
• W3217387659 cites W2150926065 @default.
• W3217387659 cites W2156615630 @default.
• W3217387659 cites W2158261276 @default.
• W3217387659 cites W2159767718 @default.
• W3217387659 cites W2162142896 @default.
• W3217387659 cites W2164242630 @default.
• W3217387659 cites W2169353806 @default.
• W3217387659 cites W2171327609 @default.
• W3217387659 cites W2179127114 @default.
• W3217387659 cites W2179438025 @default.
• W3217387659 cites W2342127666 @default.
• W3217387659 cites W2444102376 @default.
• W3217387659 cites W2492873402 @default.
• W3217387659 cites W2510962238 @default.
• W3217387659 cites W2523095706 @default.
• W3217387659 cites W2741327874 @default.
• W3217387659 cites W2742474178 @default.
• W3217387659 cites W2783035651 @default.
• W3217387659 cites W2794191669 @default.
• W3217387659 cites W2799451098 @default.
• W3217387659 cites W2809000676 @default.
• W3217387659 cites W2903183108 @default.
• W3217387659 cites W2945570991 @default.
• W3217387659 cites W2951582270 @default.
• W3217387659 cites W2952588534 @default.
• W3217387659 cites W2963583236 @default.
• W3217387659 cites W2979433844 @default.
• W3217387659 cites W2987583765 @default.
• W3217387659 cites W2989127161 @default.
• W3217387659 cites W3088521497 @default.
• W3217387659 cites W3091836256 @default.
• W3217387659 cites W3171070554 @default.
• W3217387659 doi "https://doi.org/10.1093/bib/bbab495" @default.
• W3217387659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34850822" @default.
• W3217387659 hasPublicationYear "2021" @default.
• W3217387659 type Work @default.
• W3217387659 sameAs 3217387659 @default.
• W3217387659 citedByCount "4" @default.
• W3217387659 countsByYear W32173876592022 @default.
• W3217387659 countsByYear W32173876592023 @default.
• W3217387659 crossrefType "journal-article" @default.
• W3217387659 hasAuthorship W3217387659A5003436355 @default.
• W3217387659 hasAuthorship W3217387659A5015114586 @default.
• W3217387659 hasAuthorship W3217387659A5021360029 @default.
• W3217387659 hasAuthorship W3217387659A5037779471 @default.
• W3217387659 hasAuthorship W3217387659A5041599600 @default.
• W3217387659 hasAuthorship W3217387659A5043923029 @default.
• W3217387659 hasAuthorship W3217387659A5045232150 @default.
• W3217387659 hasAuthorship W3217387659A5059972300 @default.
• W3217387659 hasAuthorship W3217387659A5083665803 @default.
• W3217387659 hasBestOaLocation W32173876591 @default.
• W3217387659 hasConcept C104317684 @default.

• next