FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217387852> ?p ?o ?g. }

• W3217387852 abstract "To explore the protective effects of bradykinin postconditioning on cardiopulmonary resuscitation (CPR) rats, and to assess the underlying mechanisms.Forty-eight adult male Sprague-Dawley (SD) rats were randomly divided into four groups according to random number table: Sham operation group, cardiac arrest (CA) group, bradykinin treatment (BK) group, and AMP-activated protein kinase (AMPK) inhibitor Compound C+ bradykinin treatment (CP+BK) group, finally, 8 rats in each group were taken for follow-up experiment. CA was induced by asphyxia. Rats in the Sham group received arteriovenous catheterization, endotracheal intubation, and mechanical ventilation, without CA. Compound C (250 μg/kg) was intraperitoneally injected in CP+BK group 30 minutes before CA, and the same volume of dimethyl sulfoxide (DMSO) was given in the remaining groups. Bradykinin (150 μg/kg) was intraperitoneally injected in BK group and CP+BK group 48 hours after restoration of spontaneous circulation (ROSC), and same volume of saline was given in the remaining groups. The neural function of rats in each group was evaluated with neurological deficit score (NDS) 72 hours after ROSC. Microtubule-associated protein light chain 3 (LC3) and p62 expressions were detected by immunohistochemistry, autophagosomes were observed by transmission electron microscopy, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method (TUNEL) assay was used to assess apoptosis.Compared with the Sham group, the NDS was decreased (60.75±5.80 vs. 80.00±0.00, P < 0.01), the expression levels of LC3 and p62 elevated [LC3 (A value): 1.04±0.64 vs. 0.40±0.14, p62 (A value): 2.75±0.57 vs. 0.36±0.12, both P < 0.05], the number of autophagosomes and apoptotic cells increased in the CA group [(39.00±8.00)% vs. (3.87±1.90)%, P < 0.05]. Compared with the CA group, the NDS (67.75±6.32 vs. 60.75±5.80, P < 0.05), the expression of LC3 (A value: 1.60±0.34 vs. 1.04±0.64, P < 0.05), and the number of autophagosomes increased in the BK group, while the expression of p62 and the rate of apoptotic cells reduced [p62 (A value): 1.51±0.32 vs. 2.75±0.57, apoptotic cells rate: (23.03±1.91)% vs. (39.00±8.00)%, both P < 0.05]. Compared with the BK group, the NDS (59.00±8.19 vs. 67.75±6.32, P < 0.05), the expression of LC3 (A value: 0.62±0.41 vs. 1.60±0.34, P < 0.05) and the number of autophagosomes declined in the CP+BK group, while the expression of p62 and the rate of apoptotic cells elevated [p62 (A value): 3.50±0.47 vs. 1.51±0.32, apoptotic cells rate: (44.53±10.15)% vs. (23.03±1.91)%, both P < 0.05].Bradykinin postconditioning played a neuroprotective role in CPR rats by activating autophagy and reducing apoptosis." @default.
• W3217387852 created "2021-12-06" @default.
• W3217387852 creator A5006119430 @default.
• W3217387852 creator A5014802707 @default.
• W3217387852 creator A5021532914 @default.
• W3217387852 creator A5030781681 @default.
• W3217387852 creator A5068313409 @default.
• W3217387852 creator A5070573117 @default.
• W3217387852 creator A5089812226 @default.
• W3217387852 date "2021-09-01" @default.
• W3217387852 modified "2023-09-26" @default.
• W3217387852 title "[Neuroprotective mechanism of autophagy in bradykinin postconditioning after cardiac arrest in rats]." @default.
• W3217387852 doi "https://doi.org/10.3760/cma.j.cn121430-20210528-00791" @default.
• W3217387852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34839869" @default.
• W3217387852 hasPublicationYear "2021" @default.
• W3217387852 type Work @default.
• W3217387852 sameAs 3217387852 @default.
• W3217387852 citedByCount "1" @default.
• W3217387852 countsByYear W32173878522023 @default.
• W3217387852 crossrefType "journal-article" @default.
• W3217387852 hasAuthorship W3217387852A5006119430 @default.
• W3217387852 hasAuthorship W3217387852A5014802707 @default.
• W3217387852 hasAuthorship W3217387852A5021532914 @default.
• W3217387852 hasAuthorship W3217387852A5030781681 @default.
• W3217387852 hasAuthorship W3217387852A5068313409 @default.
• W3217387852 hasAuthorship W3217387852A5070573117 @default.
• W3217387852 hasAuthorship W3217387852A5089812226 @default.
• W3217387852 hasConcept C126322002 @default.
• W3217387852 hasConcept C134018914 @default.
• W3217387852 hasConcept C153939273 @default.
• W3217387852 hasConcept C154113507 @default.
• W3217387852 hasConcept C170493617 @default.
• W3217387852 hasConcept C196795494 @default.
• W3217387852 hasConcept C204232928 @default.
• W3217387852 hasConcept C2777055891 @default.
• W3217387852 hasConcept C2778165595 @default.
• W3217387852 hasConcept C2779591629 @default.
• W3217387852 hasConcept C42219234 @default.
• W3217387852 hasConcept C71924100 @default.
• W3217387852 hasConcept C98274493 @default.
• W3217387852 hasConceptScore W3217387852C126322002 @default.
• W3217387852 hasConceptScore W3217387852C134018914 @default.
• W3217387852 hasConceptScore W3217387852C153939273 @default.
• W3217387852 hasConceptScore W3217387852C154113507 @default.
• W3217387852 hasConceptScore W3217387852C170493617 @default.
• W3217387852 hasConceptScore W3217387852C196795494 @default.
• W3217387852 hasConceptScore W3217387852C204232928 @default.
• W3217387852 hasConceptScore W3217387852C2777055891 @default.
• W3217387852 hasConceptScore W3217387852C2778165595 @default.
• W3217387852 hasConceptScore W3217387852C2779591629 @default.
• W3217387852 hasConceptScore W3217387852C42219234 @default.
• W3217387852 hasConceptScore W3217387852C71924100 @default.
• W3217387852 hasConceptScore W3217387852C98274493 @default.
• W3217387852 hasLocation W32173878521 @default.
• W3217387852 hasOpenAccess W3217387852 @default.
• W3217387852 hasPrimaryLocation W32173878521 @default.
• W3217387852 hasRelatedWork W11522807 @default.
• W3217387852 hasRelatedWork W12129130 @default.
• W3217387852 hasRelatedWork W1326407 @default.
• W3217387852 hasRelatedWork W14728159 @default.
• W3217387852 hasRelatedWork W14843090 @default.
• W3217387852 hasRelatedWork W18546972 @default.
• W3217387852 hasRelatedWork W20910285 @default.
• W3217387852 hasRelatedWork W4139224 @default.
• W3217387852 hasRelatedWork W7173770 @default.
• W3217387852 hasRelatedWork W13042210 @default.
• W3217387852 isParatext "false" @default.
• W3217387852 isRetracted "false" @default.
• W3217387852 magId "3217387852" @default.
• W3217387852 workType "article" @default.