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- W3217387867 abstract "<b>Introduction:</b> Therapy with the help of immunosuppressants (genetically engineered biological drugs, cytostatics, glucocorticoids) is becoming more widespread. Immunosuppressants has a powerful effect on the immune system. And, as a result, the risk of infectious diseases, including TB, increases <b>Aims and objectives:</b> Goal of research is to develop the approaches to diagnosis and prevention of tuberculosis in children with systemic autoimmune diseases, who receive immunosuppressants. <b>Methods:</b> Study of consultation cards of 279 patients with systemic diseases receiving immunosuppressants. <b>Results:</b> In most cases, rheumatoid arthritis (95%) was diagnosed. Also, diseases such as Crohn’s disease, systemic scleroderma, UC, SLE were found. Patients received adalimumab, infliximab, tocilizumab, etanercept. All patients were screened for tuberculosis infection 2 times a year (Mantoux test with 2 TE, ATR test, chest X-ray). Immunological tests were negative with long-term treatment of immunosuppressants in 65% of cases. According to the results of a screening examination in the absence of TB and the presence of LTI or other risk factors, preventive treatment was prescribed with 2H+R/Z drugs for 3-6 m. A total of 167 patients from 279 (59.8%) received preventive treatment. Tuberculosis of the respiratory organs was detected in 15 of 279 children (5.4%), for whom further treatment of immunosuppressants was suspended. 14 children out of 112 ones (12,5%), who did not receive preventive treatment, became ill with tuberculosis; and 1 child out of 167 ones (0.59%) (χ2 = 18.665, p <0.01), who received preventive treatment, didn’t get TB <b>Conclusions:</b> Preventive treatment for children with LTI reduces the risk of TB" @default.
- W3217387867 created "2021-12-06" @default.
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- W3217387867 date "2021-09-05" @default.
- W3217387867 modified "2023-09-26" @default.
- W3217387867 title "Current approaches to the prevention of tuberculosis in patients receiving immunosuppressants" @default.
- W3217387867 doi "https://doi.org/10.1183/13993003.congress-2021.pa2285" @default.
- W3217387867 hasPublicationYear "2021" @default.
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