Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217389811> ?p ?o ?g. }
- W3217389811 endingPage "16973" @default.
- W3217389811 startingPage "16956" @default.
- W3217389811 abstract "The ligand-activated transcription factor liver receptor homologue 1 (LRH-1, NR5A2) is involved in the regulation of metabolic homeostasis, including cholesterol and glucose balance. Preliminary evidence points to therapeutic potential of LRH-1 modulation in diabetes, hepatic diseases, inflammatory bowel diseases, atherosclerosis, and certain cancers, but because of a lack of suitable ligands, pharmacological control of LRH-1 has been insufficiently studied. Despite the availability of considerable structural knowledge on LRH-1, only a few ligand chemotypes have been developed, and potent, selective, and bioavailable tools to explore LRH-1 modulation in vivo are lacking. In view of the therapeutic potential of LRH-1 in prevalent diseases, improved chemical tools are needed to probe the beneficial and adverse effects of pharmacological LRH-1 modulation in sophisticated preclinical models and to further elucidate the receptor's molecular function." @default.
- W3217389811 created "2021-12-06" @default.
- W3217389811 creator A5012077256 @default.
- W3217389811 creator A5046792293 @default.
- W3217389811 creator A5078902926 @default.
- W3217389811 creator A5082330771 @default.
- W3217389811 date "2021-11-27" @default.
- W3217389811 modified "2023-09-27" @default.
- W3217389811 title "The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators" @default.
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