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• W3217406019 endingPage "103813" @default.
• W3217406019 startingPage "103813" @default.
• W3217406019 abstract "This study was aimed to explore the precise dose of corticosteroid therapy in critical COVID-19. A total of forty-five critical COVID-19 patients were enrolled. The process of critical COVID-19 was divided into alveolitis and fibrosis stages. Most nonsurvivors died in fibrosis phase. Nonsurvivors had more dyspnea symptoms, fewer days of hospitalization, shorter duration of alveolitis and fibrosis. High-dose daily corticosteroid therapy (≥150 mg/d) was associated with shorter survival time and lower lymphocyte count in fibrosis phase. Moreover, a high cumulative dose (≥604 mg) was tied to longer duration of virus shedding, lower oxygenation index (OI), higher incidence of tracheal intubation, fewer lymphocytes and higher levels of C-reactive protein (CRP) and lactate dehydrogenase (LDH). In alveolitis phase, the low-to-moderate-dose daily corticosteroid therapy and a small cumulative dose reduced lymphocytes. In conclusion, low-to-moderate dose corticosteroids may be beneficial in the fibrosis phase. High-dose corticosteroid therapy in the fibrosis phase aggravates the severity of critical COVID-19." @default.
• W3217406019 created "2021-12-06" @default.
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• W3217406019 date "2022-03-01" @default.
• W3217406019 modified "2023-10-06" @default.
• W3217406019 title "Potential benefits of precise corticosteroid therapy for critical COVID-19" @default.
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• W3217406019 doi "https://doi.org/10.1016/j.resp.2021.103813" @default.
• W3217406019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8600764" @default.
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