FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217431161> ?p ?o ?g. }

• W3217431161 endingPage "452" @default.
• W3217431161 startingPage "440" @default.
• W3217431161 abstract "In the endoplasmic reticulum (ER), the translocation-associated protein complex (TRAP), also called signal sequence receptor (SSR), includes four integral membrane proteins TRAPα/SSR1, TRAPβ/SSR2, and TRAPδ/SSR4 with the bulk of their extramembranous portions primarily in the ER lumen, whereas the extramembranous portion of TRAPγ/SSR3 is primarily cytosolic. Individually diminished expression of either TRAPα/SSR1, TRAPβ/SSR2, or TRAPδ/SSR4 mRNA is known in each case to lower TRAPα/SSR1 protein levels, leading to impaired proinsulin biosynthesis, whereas forced expression of TRAPα/SSR1 at least partially suppresses the proinsulin biosynthetic defect. Here, we report that diminished TRAPγ/SSR3 expression in pancreatic β-cells leaves TRAPα/SSR1 levels unaffected while nevertheless inhibiting cotranslational and posttranslational translocation of preproinsulin into the ER. Crucially, acute exposure to high glucose leads to a rapid upregulation of both TRAPγ/SSR3 and proinsulin protein without change in the respective mRNA levels, as observed in cultured rodent β-cell lines and confirmed in human islets. Strikingly, pancreatic β-cells with suppressed TRAPγ/SSR3 expression are blocked in glucose-dependent upregulation of proinsulin (or insulin) biosynthesis. Most remarkably, overexpression of TRAPγ/SSR3 in control β-cells raises proinsulin levels, even without boosting extracellular glucose. The data suggest the possibility that TRAPγ/SSR3 may fulfill a rate-limiting function in preproinsulin translocation across the ER membrane for proinsulin biosynthesis." @default.
• W3217431161 created "2021-12-06" @default.
• W3217431161 creator A5018010593 @default.
• W3217431161 creator A5022526821 @default.
• W3217431161 creator A5040985293 @default.
• W3217431161 creator A5072170846 @default.
• W3217431161 creator A5086298971 @default.
• W3217431161 date "2021-12-02" @default.
• W3217431161 modified "2023-10-16" @default.
• W3217431161 title "The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum" @default.
• W3217431161 cites W1881940044 @default.
• W3217431161 cites W2009020353 @default.
• W3217431161 cites W2026717550 @default.
• W3217431161 cites W2032487852 @default.
• W3217431161 cites W2037347257 @default.
• W3217431161 cites W2069247329 @default.
• W3217431161 cites W2097198889 @default.
• W3217431161 cites W2101902163 @default.
• W3217431161 cites W2105308918 @default.
• W3217431161 cites W2105713675 @default.
• W3217431161 cites W2148749248 @default.
• W3217431161 cites W2153134360 @default.
• W3217431161 cites W2162824898 @default.
• W3217431161 cites W2580186481 @default.
• W3217431161 cites W2589383075 @default.
• W3217431161 cites W2771127244 @default.
• W3217431161 cites W2889562110 @default.
• W3217431161 cites W2890986735 @default.
• W3217431161 cites W2894662039 @default.
• W3217431161 cites W2929477372 @default.
• W3217431161 cites W2949822571 @default.
• W3217431161 cites W2953056615 @default.
• W3217431161 cites W2993782769 @default.
• W3217431161 cites W2999361287 @default.
• W3217431161 cites W3005033638 @default.
• W3217431161 cites W3017988969 @default.
• W3217431161 cites W3083970205 @default.
• W3217431161 cites W3097054707 @default.
• W3217431161 cites W3122378831 @default.
• W3217431161 cites W3122519595 @default.
• W3217431161 cites W3142143740 @default.
• W3217431161 doi "https://doi.org/10.2337/db21-0638" @default.
• W3217431161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34857543" @default.
• W3217431161 hasPublicationYear "2021" @default.
• W3217431161 type Work @default.
• W3217431161 sameAs 3217431161 @default.
• W3217431161 citedByCount "3" @default.
• W3217431161 countsByYear W32174311612022 @default.
• W3217431161 countsByYear W32174311612023 @default.
• W3217431161 crossrefType "journal-article" @default.
• W3217431161 hasAuthorship W3217431161A5018010593 @default.
• W3217431161 hasAuthorship W3217431161A5022526821 @default.
• W3217431161 hasAuthorship W3217431161A5040985293 @default.
• W3217431161 hasAuthorship W3217431161A5072170846 @default.
• W3217431161 hasAuthorship W3217431161A5086298971 @default.
• W3217431161 hasBestOaLocation W32174311611 @default.
• W3217431161 hasConcept C104317684 @default.
• W3217431161 hasConcept C121099081 @default.
• W3217431161 hasConcept C126322002 @default.
• W3217431161 hasConcept C127413603 @default.
• W3217431161 hasConcept C134018914 @default.
• W3217431161 hasConcept C138626823 @default.
• W3217431161 hasConcept C158617107 @default.
• W3217431161 hasConcept C181199279 @default.
• W3217431161 hasConcept C185592680 @default.
• W3217431161 hasConcept C2779306644 @default.
• W3217431161 hasConcept C553450214 @default.
• W3217431161 hasConcept C55493867 @default.
• W3217431161 hasConcept C71924100 @default.
• W3217431161 hasConcept C86803240 @default.
• W3217431161 hasConcept C87717796 @default.
• W3217431161 hasConcept C90061646 @default.
• W3217431161 hasConcept C95444343 @default.
• W3217431161 hasConcept C98539663 @default.
• W3217431161 hasConceptScore W3217431161C104317684 @default.
• W3217431161 hasConceptScore W3217431161C121099081 @default.
• W3217431161 hasConceptScore W3217431161C126322002 @default.
• W3217431161 hasConceptScore W3217431161C127413603 @default.
• W3217431161 hasConceptScore W3217431161C134018914 @default.
• W3217431161 hasConceptScore W3217431161C138626823 @default.
• W3217431161 hasConceptScore W3217431161C158617107 @default.
• W3217431161 hasConceptScore W3217431161C181199279 @default.
• W3217431161 hasConceptScore W3217431161C185592680 @default.
• W3217431161 hasConceptScore W3217431161C2779306644 @default.
• W3217431161 hasConceptScore W3217431161C553450214 @default.
• W3217431161 hasConceptScore W3217431161C55493867 @default.
• W3217431161 hasConceptScore W3217431161C71924100 @default.
• W3217431161 hasConceptScore W3217431161C86803240 @default.
• W3217431161 hasConceptScore W3217431161C87717796 @default.
• W3217431161 hasConceptScore W3217431161C90061646 @default.
• W3217431161 hasConceptScore W3217431161C95444343 @default.
• W3217431161 hasConceptScore W3217431161C98539663 @default.
• W3217431161 hasIssue "3" @default.
• W3217431161 hasLocation W32174311611 @default.
• W3217431161 hasLocation W32174311612 @default.
• W3217431161 hasLocation W32174311613 @default.
• W3217431161 hasLocation W32174311614 @default.
• W3217431161 hasLocation W32174311615 @default.

• next