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• W3217461285 abstract "High-fat Western diets contribute to tissue dysregulation of fatty acid and glucose intake, resulting in obesity and insulin resistance and their sequelae, including atherosclerosis. New therapies are desperately needed to interrupt this epidemic. The significant idea driving this research is that the understudied regulation of fatty acid entry into tissues at the endothelial cell (EC) interface can provide novel therapeutic targets that will greatly modify health outcomes and advance health-related knowledge. Dysfunctional endothelium, defined as activated, pro-inflammatory, and pro-thrombotic, is critical in atherosclerosis initiation, in modulating thrombotic events that could result in myocardial infarction and stroke, and is a hallmark of insulin resistance. Dyslipidemia from high-fat diets overwhelmingly contributes to the development of dysfunctional endothelium. CD36 acts as a receptor for pathological ligands generated by high-fat diets and in fatty acid uptake, and therefore, it may additionally contribute to EC dysfunction. We created EC CD36 knockout (CD36°) mice using cre-lox technology and a cre-promoter that does not eliminate CD36 in hematopoietic cells (Tie2e cre). These mice were studied on different diets, and crossed to the low density lipoprotein receptor (LDLR) knockout for atherosclerosis assessment. Our data show that EC CD36° and EC CD36°/LDLR° mice have metabolic changes suggestive of an uncompensated role for EC CD36 in fatty acid uptake. The mice lacking expression of EC CD36 had increased glucose clearance compared with controls when fed with multiple diets. EC CD36° male mice showed increased carbohydrate utilization and decreased energy expenditure by indirect calorimetry. Female EC CD36°/LDLR° mice have reduced atherosclerosis. Taken together, these data support a significant role for EC CD36 in systemic metabolism and reveal sex-specific impact on atherosclerosis and energy substrate use." @default.
• W3217461285 created "2021-12-06" @default.
• W3217461285 creator A5022534546 @default.
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• W3217461285 date "2021-11-23" @default.
• W3217461285 modified "2023-09-26" @default.
• W3217461285 title "Endothelial Cell CD36 Reduces Atherosclerosis and Controls Systemic Metabolism" @default.
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• W3217461285 cites W1512516272 @default.
• W3217461285 cites W1541675330 @default.
• W3217461285 cites W1549631663 @default.
• W3217461285 cites W1591469694 @default.
• W3217461285 cites W1653408396 @default.
• W3217461285 cites W1984150991 @default.
• W3217461285 cites W1990720074 @default.
• W3217461285 cites W1991274029 @default.
• W3217461285 cites W1992479323 @default.
• W3217461285 cites W2001496481 @default.
• W3217461285 cites W2002456170 @default.
• W3217461285 cites W2002812554 @default.
• W3217461285 cites W2013899166 @default.
• W3217461285 cites W2014610911 @default.
• W3217461285 cites W2019685005 @default.
• W3217461285 cites W2025439383 @default.
• W3217461285 cites W2028658648 @default.
• W3217461285 cites W2029684068 @default.
• W3217461285 cites W2034779218 @default.
• W3217461285 cites W2038147480 @default.
• W3217461285 cites W2040197119 @default.
• W3217461285 cites W2040261887 @default.
• W3217461285 cites W2045772297 @default.
• W3217461285 cites W2049335989 @default.
• W3217461285 cites W2053655408 @default.
• W3217461285 cites W2055057583 @default.
• W3217461285 cites W2055469239 @default.
• W3217461285 cites W2056398216 @default.
• W3217461285 cites W2058194924 @default.
• W3217461285 cites W2069663822 @default.
• W3217461285 cites W2070690965 @default.
• W3217461285 cites W2074592896 @default.
• W3217461285 cites W2077296914 @default.
• W3217461285 cites W2083507739 @default.
• W3217461285 cites W2092032357 @default.
• W3217461285 cites W2097901390 @default.
• W3217461285 cites W2099635702 @default.
• W3217461285 cites W2107542389 @default.
• W3217461285 cites W2114328654 @default.
• W3217461285 cites W2122852774 @default.
• W3217461285 cites W2125242137 @default.
• W3217461285 cites W2126408606 @default.
• W3217461285 cites W2129449137 @default.
• W3217461285 cites W2129527328 @default.
• W3217461285 cites W2133246254 @default.
• W3217461285 cites W2133850792 @default.
• W3217461285 cites W2134096102 @default.
• W3217461285 cites W2134101952 @default.
• W3217461285 cites W2134252550 @default.
• W3217461285 cites W2136943950 @default.
• W3217461285 cites W2137506791 @default.
• W3217461285 cites W2147135174 @default.
• W3217461285 cites W2153245546 @default.
• W3217461285 cites W2154455571 @default.
• W3217461285 cites W2155441375 @default.
• W3217461285 cites W2158974927 @default.
• W3217461285 cites W2164212234 @default.
• W3217461285 cites W2165266002 @default.
• W3217461285 cites W2165628817 @default.
• W3217461285 cites W2167810162 @default.
• W3217461285 cites W2267794917 @default.
• W3217461285 cites W2316741386 @default.
• W3217461285 cites W2524443653 @default.
• W3217461285 cites W2796174912 @default.
• W3217461285 cites W2799755811 @default.
• W3217461285 cites W2883909768 @default.
• W3217461285 cites W2913214687 @default.
• W3217461285 cites W2914125461 @default.
• W3217461285 cites W2950484331 @default.
• W3217461285 cites W2964245665 @default.
• W3217461285 cites W2965229793 @default.
• W3217461285 cites W2995654976 @default.
• W3217461285 cites W3003265560 @default.
• W3217461285 cites W3087320494 @default.
• W3217461285 cites W3127989294 @default.
• W3217461285 cites W3140276280 @default.
• W3217461285 cites W3154955118 @default.
• W3217461285 cites W3184002526 @default.
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• W3217461285 doi "https://doi.org/10.3389/fcvm.2021.768481" @default.
• W3217461285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34888367" @default.
• W3217461285 hasPublicationYear "2021" @default.
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