Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217478524> ?p ?o ?g. }
- W3217478524 abstract "Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is one of the main types of intestinal inflammatory diseases with intestine mucosal immune disorder. Intestine mucosal immune system plays a remarkable and important role in the etiology and pathogenesis of IBD. Therefore, understanding the intestine mucosal immune mechanism is a key step to develop therapeutic interventions for IBD. Intestine mucosal immune system and IBD are influenced by various factors, such as inflammation, gut permeability, gut microbiota, and nutrients. Among these factors, emerging evidence show that nutrients play a key role in inflammation activation, integrity of intestinal barrier, and immune cell modulation. Lactoferrin (LF), an iron-binding glycoprotein belonging to transferrin family, is a dietary bioactive component abundantly found in mammalian milk. Notably, LF has been reported to perform diverse biological functions including antibacterial activity, anti-inflammatory activity, intestinal barrier protection, and immune cell modulation, and is involved in maintaining intestine mucosal immune homeostasis. The improved understanding of the properties of LF in intestine mucosal immune system and IBD will facilitate its application in nutrition, clinical medicine, and health. Herein, this review outlines the recent advancements on LF as a potential therapeutic intervention for IBD associated with intestine mucosal immune system dysfunction. We hope this review will provide a reference for future studies and lay a theoretical foundation for LF-based therapeutic interventions for IBD by understanding the particular effects of LF on intestine mucosal immune system." @default.
- W3217478524 created "2021-12-06" @default.
- W3217478524 creator A5004319733 @default.
- W3217478524 creator A5017170149 @default.
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- W3217478524 creator A5086664284 @default.
- W3217478524 creator A5091440140 @default.
- W3217478524 date "2021-11-25" @default.
- W3217478524 modified "2023-10-17" @default.
- W3217478524 title "The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease" @default.
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