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- W3217489025 endingPage "816" @default.
- W3217489025 startingPage "805" @default.
- W3217489025 abstract "A growing number of epidemiological and experimental studies has established that circadian disruption is strongly associated with psychiatric disorders, including major depressive disorder (MDD). This association is becoming increasingly relevant considering that modern lifestyles, social zeitgebers (time cues) and genetic variants contribute to disrupting circadian rhythms that may lead to psychiatric disorders. Circadian abnormalities associated with MDD include dysregulated rhythms of sleep, temperature, hormonal secretions, and mood which are modulated by the molecular clock. Rapid-acting antidepressants such as subanesthetic ketamine and sleep deprivation therapy can improve symptoms within 24 h in a subset of depressed patients, in striking contrast to conventional treatments, which generally require weeks for a full clinical response. Importantly, animal data show that sleep deprivation and ketamine have overlapping effects on clock gene expression. Furthermore, emerging data implicate the circadian system as a critical component involved in rapid antidepressant responses via several intracellular signaling pathways such as GSK3β, mTOR, MAPK, and NOTCH to initiate synaptic plasticity. Future research on the relationship between depression and the circadian clock may contribute to the development of novel therapeutic strategies for depression-like symptoms. In this review we summarize recent evidence describing: (1) how the circadian clock is implicated in depression, (2) how clock genes may contribute to fast-acting antidepressants, and (3) the mechanistic links between the clock genes driving circadian rhythms and neuroplasticity." @default.
- W3217489025 created "2021-12-06" @default.
- W3217489025 creator A5013754150 @default.
- W3217489025 creator A5019252768 @default.
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- W3217489025 creator A5040864182 @default.
- W3217489025 creator A5054827230 @default.
- W3217489025 creator A5080427251 @default.
- W3217489025 date "2021-11-27" @default.
- W3217489025 modified "2023-10-18" @default.
- W3217489025 title "Rapid-acting antidepressants and the circadian clock" @default.
- W3217489025 cites W1486750289 @default.
- W3217489025 cites W1507341955 @default.
- W3217489025 cites W1632905719 @default.
- W3217489025 cites W1820117428 @default.
- W3217489025 cites W1903124221 @default.
- W3217489025 cites W1942495330 @default.
- W3217489025 cites W1965581817 @default.
- W3217489025 cites W1968748283 @default.
- W3217489025 cites W1974227915 @default.
- W3217489025 cites W1974822318 @default.
- W3217489025 cites W1975182501 @default.
- W3217489025 cites W1976379858 @default.
- W3217489025 cites W1977647750 @default.
- W3217489025 cites W1981097208 @default.
- W3217489025 cites W1981307611 @default.
- W3217489025 cites W1986185847 @default.
- W3217489025 cites W1989108716 @default.
- W3217489025 cites W1991021935 @default.
- W3217489025 cites W1994345197 @default.
- W3217489025 cites W1995120027 @default.
- W3217489025 cites W1995200202 @default.
- W3217489025 cites W1997718482 @default.
- W3217489025 cites W2001997781 @default.
- W3217489025 cites W2002673415 @default.
- W3217489025 cites W2003916765 @default.
- W3217489025 cites W2003982930 @default.
- W3217489025 cites W2005613383 @default.
- W3217489025 cites W2007091097 @default.
- W3217489025 cites W2009010658 @default.
- W3217489025 cites W2011039340 @default.
- W3217489025 cites W2011282592 @default.
- W3217489025 cites W2012199810 @default.
- W3217489025 cites W2018553282 @default.
- W3217489025 cites W2020333671 @default.
- W3217489025 cites W2020371172 @default.
- W3217489025 cites W2021748681 @default.
- W3217489025 cites W2023848782 @default.
- W3217489025 cites W2024774829 @default.
- W3217489025 cites W2026743859 @default.
- W3217489025 cites W2027575852 @default.
- W3217489025 cites W2027764072 @default.
- W3217489025 cites W2029819292 @default.
- W3217489025 cites W2032739515 @default.
- W3217489025 cites W2036520019 @default.
- W3217489025 cites W2037145446 @default.
- W3217489025 cites W2039923358 @default.
- W3217489025 cites W2041979789 @default.
- W3217489025 cites W2042045791 @default.
- W3217489025 cites W2044458189 @default.
- W3217489025 cites W2044652422 @default.
- W3217489025 cites W2045072430 @default.
- W3217489025 cites W2051187163 @default.
- W3217489025 cites W2051700776 @default.
- W3217489025 cites W2060035717 @default.
- W3217489025 cites W2060550584 @default.
- W3217489025 cites W2061711185 @default.
- W3217489025 cites W2061864948 @default.
- W3217489025 cites W2067102106 @default.
- W3217489025 cites W2068327995 @default.
- W3217489025 cites W2075361934 @default.
- W3217489025 cites W2076267123 @default.
- W3217489025 cites W2077477890 @default.
- W3217489025 cites W2078546989 @default.
- W3217489025 cites W2080758948 @default.
- W3217489025 cites W2086588094 @default.
- W3217489025 cites W2089351762 @default.
- W3217489025 cites W2091531174 @default.
- W3217489025 cites W2094166526 @default.
- W3217489025 cites W2094867986 @default.
- W3217489025 cites W2100229639 @default.
- W3217489025 cites W2106623141 @default.
- W3217489025 cites W2111344509 @default.
- W3217489025 cites W2111842512 @default.
- W3217489025 cites W2117389116 @default.
- W3217489025 cites W2120115128 @default.
- W3217489025 cites W2120144854 @default.
- W3217489025 cites W2129084135 @default.
- W3217489025 cites W2133693969 @default.
- W3217489025 cites W2133918896 @default.
- W3217489025 cites W2134597112 @default.
- W3217489025 cites W2144813428 @default.
- W3217489025 cites W2147897732 @default.
- W3217489025 cites W2149119305 @default.
- W3217489025 cites W2149677176 @default.
- W3217489025 cites W2155654222 @default.
- W3217489025 cites W2159094371 @default.