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• W3217496680 abstract "Immune checkpoint inhibitors (ICIs) are now a cornerstone of advanced non-small cell lung cancer (NSCLC) treatment. However, heterogeneity in ICI benefit is significant, and it is increasingly apparent that resistance is likely multifactorial. As cigarette smoking is associated with increased tumour mutation burden (TMB) [ [1] Gainor J.F. Rizvi H. Jimenez Aguilar E. Skoulidis F. Yeap B.Y. Naidoo J. et al. Clinical activity of programmed cell death 1 (PD-1) blockade in never, light, and heavy smokers with non-small-cell lung cancer and PD-L1 expression ≥50. Ann Oncol. 2020; 31: 404-411 Abstract Full Text Full Text PDF PubMed Scopus (31) Google Scholar , [2] Wang X. Ricciuti B. Alessi J.V. Nguyen T. Awad M.M. Lin X. et al. Smoking history as a potential predictor of immune checkpoint inhibitor efficacy in metastatic non-small cell lung cancer. J Natl Cancer Inst. 2021; (Online only at this stage. Online issue)https://doi.org/10.1093/jnci/djab116 Crossref Google Scholar ], it is possible that ‘never smokers’ could obtain less ICI benefit. Recent study-level meta-analyses report that never smokers may obtain less effect from ICIs than previous/current smokers [ [3] Mo J. Hu X. Gu L. Chen B. Khadaroo P.A. Shen Z. et al. Smokers or non-smokers: who benefits more from immune checkpoint inhibitors in treatment of malignancies? An up-to-date meta-analysis. World J Surg Oncol. 2020; 18: 15 Crossref PubMed Scopus (29) Google Scholar , [4] Dai L. Jin B. Liu T. Chen J. Li G. Dang J. The effect of smoking status on efficacy of immune checkpoint inhibitors in metastatic non-small cell lung cancer: a systematic review and meta-analysis. EClinicalMedicine. 2021; 38 Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar ], while small cohort studies report prognosis may be poorer in never smokers compared to previous/current smokers [ [1] Gainor J.F. Rizvi H. Jimenez Aguilar E. Skoulidis F. Yeap B.Y. Naidoo J. et al. Clinical activity of programmed cell death 1 (PD-1) blockade in never, light, and heavy smokers with non-small-cell lung cancer and PD-L1 expression ≥50. Ann Oncol. 2020; 31: 404-411 Abstract Full Text Full Text PDF PubMed Scopus (31) Google Scholar , [2] Wang X. Ricciuti B. Alessi J.V. Nguyen T. Awad M.M. Lin X. et al. Smoking history as a potential predictor of immune checkpoint inhibitor efficacy in metastatic non-small cell lung cancer. J Natl Cancer Inst. 2021; (Online only at this stage. Online issue)https://doi.org/10.1093/jnci/djab116 Crossref Google Scholar ]. However, these studies (1) used small cohorts, (2) failed to recognise previous and current smokers have different TMBs, and (3) have not reported according to PDL1 expression." @default.
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• W3217496680 date "2022-01-01" @default.
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• W3217496680 title "Smoking and immunotherapy efficacy in lung cancer by PDL1 subgroups: An individual participant data meta-analysis of atezolizumab clinical trials" @default.
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• W3217496680 doi "https://doi.org/10.1016/j.ejca.2021.10.020" @default.
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