FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217498351> ?p ?o ?g. }

• W3217498351 endingPage "12872" @default.
• W3217498351 startingPage "12872" @default.
• W3217498351 abstract "Ovarian cancer (OC) is the deadliest among all gynecological cancers. Epidemiological studies showed that obesity might influence many cancers including OC. One of the key factors that may link obesity and OC is leptin (LEP), known as an adipokine with pleiotropic effects on body homeostasis. This study aims to investigate the expression pattern of LEP, assess the methylation profiles of LEP and their associations with clinicopathological features including survival outcomes of OC patients. The protein expression of LEP was evaluated in 208 samples using both tissue microarray and immunohistochemistry techniques. The methylation profiles of LEP were measured in 63 formalin-fixed, paraffin-embedded tumor tissues by quantitative polymerase chain reaction using a MethyLight assay. Our results showed a significant association of LEP protein overexpression with several clinicopathological variables, mainly tumor subtype, LVI, age of menarche, tumor size and stage (p < 0.04). Kaplan–Meier analysis (using low expression versus high expression as a discriminator) indicated that LEP protein overexpression is a powerful positive prognosticator of both OC recurrence (DFS) and disease-specific survival (DSS) in our OC cohort (log-rank p = 0.01 and p = 0.002, respectively). This implies that patients with high LEP expression profiles live longer with less recurrence rates. Methylation analysis results demonstrated a clear association between no/low LEP protein expression pattern (38%) and LEP promoter CpG island hypermethylation (43%). Results of this study suggest that LEP is a powerful prognosticator of OC recurrence and DSS. LEP expression in OC seems to be regulated by its promoter hypermethylation through gene partial/total silencing. Further multi-institutional studies using larger cohorts are required to demystify the intricate molecular functions of this leptin-driven effects in OC pathophysiology and to accurately assess its theranostic potential and validate its prognostic/predictive power in OC onset, progression towards more effective and personalized management of OC patients." @default.
• W3217498351 created "2021-12-06" @default.
• W3217498351 creator A5039910761 @default.
• W3217498351 creator A5040878674 @default.
• W3217498351 creator A5051729036 @default.
• W3217498351 creator A5052350300 @default.
• W3217498351 creator A5057053037 @default.
• W3217498351 creator A5067239285 @default.
• W3217498351 creator A5077011338 @default.
• W3217498351 creator A5082949438 @default.
• W3217498351 creator A5083603407 @default.
• W3217498351 creator A5086398273 @default.
• W3217498351 date "2021-11-28" @default.
• W3217498351 modified "2023-10-03" @default.
• W3217498351 title "Leptin Protein Expression and Promoter Methylation in Ovarian Cancer: A Strong Prognostic Value with Theranostic Promises" @default.
• W3217498351 cites W1488600094 @default.
• W3217498351 cites W1580084546 @default.
• W3217498351 cites W1965472905 @default.
• W3217498351 cites W1975382160 @default.
• W3217498351 cites W1980870023 @default.
• W3217498351 cites W1980991473 @default.
• W3217498351 cites W2002736272 @default.
• W3217498351 cites W2004882228 @default.
• W3217498351 cites W2012630942 @default.
• W3217498351 cites W2025940044 @default.
• W3217498351 cites W2027112907 @default.
• W3217498351 cites W2027646895 @default.
• W3217498351 cites W2027676433 @default.
• W3217498351 cites W2028313225 @default.
• W3217498351 cites W2036849525 @default.
• W3217498351 cites W2061623083 @default.
• W3217498351 cites W2063575312 @default.
• W3217498351 cites W2067625941 @default.
• W3217498351 cites W2070190142 @default.
• W3217498351 cites W2079690592 @default.
• W3217498351 cites W2099521499 @default.
• W3217498351 cites W2100782535 @default.
• W3217498351 cites W2127205066 @default.
• W3217498351 cites W2128296774 @default.
• W3217498351 cites W2138102988 @default.
• W3217498351 cites W2143085509 @default.
• W3217498351 cites W2150197335 @default.
• W3217498351 cites W2160172641 @default.
• W3217498351 cites W2161390044 @default.
• W3217498351 cites W2164346577 @default.
• W3217498351 cites W2170380504 @default.
• W3217498351 cites W2217355440 @default.
• W3217498351 cites W2225488124 @default.
• W3217498351 cites W2234784039 @default.
• W3217498351 cites W2255721471 @default.
• W3217498351 cites W2277140261 @default.
• W3217498351 cites W2318251140 @default.
• W3217498351 cites W2378532668 @default.
• W3217498351 cites W2434640362 @default.
• W3217498351 cites W2484362226 @default.
• W3217498351 cites W2521343666 @default.
• W3217498351 cites W2596652271 @default.
• W3217498351 cites W2602781230 @default.
• W3217498351 cites W2618143438 @default.
• W3217498351 cites W2740173227 @default.
• W3217498351 cites W2743605511 @default.
• W3217498351 cites W2756471067 @default.
• W3217498351 cites W2804993332 @default.
• W3217498351 cites W2805508348 @default.
• W3217498351 cites W2807649309 @default.
• W3217498351 cites W2810136617 @default.
• W3217498351 cites W2900423390 @default.
• W3217498351 cites W2902419363 @default.
• W3217498351 cites W2910560574 @default.
• W3217498351 cites W2922069015 @default.
• W3217498351 cites W2946377670 @default.
• W3217498351 cites W2947328322 @default.
• W3217498351 cites W2949685167 @default.
• W3217498351 cites W2966964832 @default.
• W3217498351 cites W2977736386 @default.
• W3217498351 cites W2999417355 @default.
• W3217498351 cites W3007419720 @default.
• W3217498351 cites W3010146989 @default.
• W3217498351 cites W3041287992 @default.
• W3217498351 cites W3049167578 @default.
• W3217498351 cites W3087919306 @default.
• W3217498351 cites W3088349261 @default.
• W3217498351 cites W3092888988 @default.
• W3217498351 cites W3112887444 @default.
• W3217498351 cites W3134118467 @default.
• W3217498351 cites W3134522652 @default.
• W3217498351 cites W3162505504 @default.
• W3217498351 cites W3165163479 @default.
• W3217498351 cites W3173058446 @default.
• W3217498351 cites W3174203635 @default.
• W3217498351 cites W3188391722 @default.
• W3217498351 cites W3188674202 @default.
• W3217498351 cites W3190412793 @default.
• W3217498351 cites W3190579723 @default.
• W3217498351 cites W3195293962 @default.
• W3217498351 cites W3203160280 @default.
• W3217498351 cites W6013967 @default.
• W3217498351 cites W828328739 @default.

• next