FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217503492> ?p ?o ?g. }

• W3217503492 endingPage "100058" @default.
• W3217503492 startingPage "100058" @default.
• W3217503492 abstract "gp130 is the signal-transducing receptor for the Interleukin (IL)-6 type cytokines IL-6 and IL-11. To induce signaling, IL-6 forms a complex with IL-6 receptor (IL-6R) and IL-11 with IL-11 receptor (IL-11R). Membrane-bound IL-6R and IL-11R in complex with gp130 and the cytokine mediate classic-signaling, whereas trans-signaling needs soluble IL-6R and IL-11R variants. Interleukin (IL)-6 trans-signaling is of particular importance because it drives the development of autoimmune diseases, including rheumatoid arthritis and chronic inflammatory bowel diseases, whereas a role for IL-11 trans-signaling remains elusive. Soluble gp130 selectively inhibits trans-signaling of IL-6 whereas both, classic- and trans-signaling are abrogated by IL-6- and IL-6R-antibodies. Recently, we described an optimized sgp130 variant, which carries three amino acid substitutions T102Y/Q113F/N114L (sgp130FlyFc) resulting in reduced inhibition of IL-11 trans-signaling by increasing the affinity of sgp130 for the site I of IL-6. Moreover, we described that the patient mutation R281Q in gp130 results in reduced IL-11 signaling. Here, we show that the combination of T102Y/Q113F/N114L and R281Q in the new variant sgp130FlyRFc results in complete preservation of IL-11 mediated trans-signaling, whereas inhibition of IL-6 trans-signaling is maintained. Since sgp130Fc (olamkicept) has successfully completed a phase IIa trial in Crohn's disease (CD) and ulcerative colitis, sgp130FlyRFc might serve as second-generation therapeutic to diminish IL-11 trans-signaling cross-reactivity." @default.
• W3217503492 created "2021-12-06" @default.
• W3217503492 creator A5000593127 @default.
• W3217503492 creator A5008534812 @default.
• W3217503492 creator A5027842348 @default.
• W3217503492 creator A5034675603 @default.
• W3217503492 creator A5053465992 @default.
• W3217503492 creator A5062365573 @default.
• W3217503492 creator A5088470216 @default.
• W3217503492 date "2021-12-01" @default.
• W3217503492 modified "2023-10-14" @default.
• W3217503492 title "Exclusive inhibition of IL-6 trans-signaling by soluble gp130FlyRFc" @default.
• W3217503492 cites W1567207438 @default.
• W3217503492 cites W1597588755 @default.
• W3217503492 cites W1723158139 @default.
• W3217503492 cites W1846093453 @default.
• W3217503492 cites W1856650971 @default.
• W3217503492 cites W1969682613 @default.
• W3217503492 cites W1989542542 @default.
• W3217503492 cites W1996650419 @default.
• W3217503492 cites W1998847200 @default.
• W3217503492 cites W2005260135 @default.
• W3217503492 cites W2007606465 @default.
• W3217503492 cites W2012967865 @default.
• W3217503492 cites W2018261512 @default.
• W3217503492 cites W2024171722 @default.
• W3217503492 cites W2024255214 @default.
• W3217503492 cites W2032848182 @default.
• W3217503492 cites W2032999541 @default.
• W3217503492 cites W2038479043 @default.
• W3217503492 cites W2082626794 @default.
• W3217503492 cites W2093206483 @default.
• W3217503492 cites W2093643472 @default.
• W3217503492 cites W2110463517 @default.
• W3217503492 cites W2117521006 @default.
• W3217503492 cites W2120088649 @default.
• W3217503492 cites W2266423547 @default.
• W3217503492 cites W2558510664 @default.
• W3217503492 cites W2769120956 @default.
• W3217503492 cites W2770331207 @default.
• W3217503492 cites W2937789693 @default.
• W3217503492 cites W3033020384 @default.
• W3217503492 cites W3133637024 @default.
• W3217503492 cites W3173233514 @default.
• W3217503492 cites W3193523037 @default.
• W3217503492 cites W4244158828 @default.
• W3217503492 cites W1992358981 @default.
• W3217503492 doi "https://doi.org/10.1016/j.cytox.2021.100058" @default.
• W3217503492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34927050" @default.
• W3217503492 hasPublicationYear "2021" @default.
• W3217503492 type Work @default.
• W3217503492 sameAs 3217503492 @default.
• W3217503492 citedByCount "6" @default.
• W3217503492 countsByYear W32175034922022 @default.
• W3217503492 countsByYear W32175034922023 @default.
• W3217503492 crossrefType "journal-article" @default.
• W3217503492 hasAuthorship W3217503492A5000593127 @default.
• W3217503492 hasAuthorship W3217503492A5008534812 @default.
• W3217503492 hasAuthorship W3217503492A5027842348 @default.
• W3217503492 hasAuthorship W3217503492A5034675603 @default.
• W3217503492 hasAuthorship W3217503492A5053465992 @default.
• W3217503492 hasAuthorship W3217503492A5062365573 @default.
• W3217503492 hasAuthorship W3217503492A5088470216 @default.
• W3217503492 hasBestOaLocation W32175034921 @default.
• W3217503492 hasConcept C11988809 @default.
• W3217503492 hasConcept C126037660 @default.
• W3217503492 hasConcept C150555746 @default.
• W3217503492 hasConcept C170493617 @default.
• W3217503492 hasConcept C185592680 @default.
• W3217503492 hasConcept C203014093 @default.
• W3217503492 hasConcept C2775855021 @default.
• W3217503492 hasConcept C2778690821 @default.
• W3217503492 hasConcept C54355233 @default.
• W3217503492 hasConcept C62478195 @default.
• W3217503492 hasConcept C74172505 @default.
• W3217503492 hasConcept C86803240 @default.
• W3217503492 hasConcept C95444343 @default.
• W3217503492 hasConceptScore W3217503492C11988809 @default.
• W3217503492 hasConceptScore W3217503492C126037660 @default.
• W3217503492 hasConceptScore W3217503492C150555746 @default.
• W3217503492 hasConceptScore W3217503492C170493617 @default.
• W3217503492 hasConceptScore W3217503492C185592680 @default.
• W3217503492 hasConceptScore W3217503492C203014093 @default.
• W3217503492 hasConceptScore W3217503492C2775855021 @default.
• W3217503492 hasConceptScore W3217503492C2778690821 @default.
• W3217503492 hasConceptScore W3217503492C54355233 @default.
• W3217503492 hasConceptScore W3217503492C62478195 @default.
• W3217503492 hasConceptScore W3217503492C74172505 @default.
• W3217503492 hasConceptScore W3217503492C86803240 @default.
• W3217503492 hasConceptScore W3217503492C95444343 @default.
• W3217503492 hasFunder F4320320879 @default.
• W3217503492 hasIssue "4" @default.
• W3217503492 hasLocation W32175034921 @default.
• W3217503492 hasLocation W32175034922 @default.
• W3217503492 hasLocation W32175034923 @default.
• W3217503492 hasLocation W32175034924 @default.
• W3217503492 hasOpenAccess W3217503492 @default.
• W3217503492 hasPrimaryLocation W32175034921 @default.

• next