Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217504860> ?p ?o ?g. }
- W3217504860 endingPage "100083" @default.
- W3217504860 startingPage "100083" @default.
- W3217504860 abstract "Elizabethkingia species are ubiquitous in aquatic environments, colonize water systems in healthcare settings and are emerging opportunistic pathogens with reports surfacing in 25 countries across six continents. Elizabethkingia infections are challenging to treat, and case fatality rates are high. Chromosomal blaB, blaGOB and blaCME genes encoding carbapenemases and cephalosporinases are unique to Elizabethkingia spp. and reports of concomitant resistance to aminoglycosides, fluoroquinolones and sulfamethoxazole-trimethoprim are known. Here, we characterized whole-genome sequences of 94 Elizabethkingia isolates carrying multiple wide-spectrum metallo-β-lactamase (blaBand blaGOB) and extended-spectrum serine‑β-lactamase (blaCME) genes from Australian aquatic environments and performed comparative phylogenomic analyses against national clinical and international strains. qPCR was performed to quantify the levels of Elizabethkingia species in the source environments. Antibiotic MIC testing revealed significant resistance to carbapenems and cephalosporins but susceptibility to fluoroquinolones, tetracyclines and trimethoprim-sulfamethoxazole. Phylogenetics show that three environmental E. anophelis isolates are closely related to E. anophelis from Australian clinical isolates (∼36 SNPs), and a new species, E. umeracha sp. novel, was discovered. Genomic signatures provide insight into potentially shared origins and a capacity to transfer mobile genetic elements with both national and international isolates." @default.
- W3217504860 created "2021-12-06" @default.
- W3217504860 creator A5004522511 @default.
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- W3217504860 creator A5054595285 @default.
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- W3217504860 creator A5072354171 @default.
- W3217504860 creator A5073778415 @default.
- W3217504860 creator A5074670629 @default.
- W3217504860 creator A5088062526 @default.
- W3217504860 date "2022-01-01" @default.
- W3217504860 modified "2023-09-30" @default.
- W3217504860 title "Genomic analysis of Elizabethkingia species from aquatic environments: Evidence for potential clinical transmission" @default.
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