Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217507071> ?p ?o ?g. }
- W3217507071 abstract "Cellular quiescence is a state of reversible cell cycle arrest that is associated with tissue dormancy. Timely regulated entry into and exit from quiescence is important for processes such as tissue homeostasis, tissue repair, stem cell maintenance, developmental processes, and immunity. However, little is known about processes that control the mechanical adaption to cell behavior changes during the transition from quiescence to proliferation. Here, we show that quiescent human keratinocyte monolayers sustain an actinomyosin-based system that facilitates global cell sheet displacements upon serum-stimulated exit from quiescence. Mechanistically, exposure of quiescent cells to serum-borne mitogens leads to rapid amplification of preexisting contractile sites, leading to a burst in monolayer tension that subsequently drives large-scale displacements of otherwise motility-restricted monolayers. The stress level after quiescence exit correlates with the level of quiescence depth at the time of activation, and a critical stress magnitude must be reached to overcome the cell sheet displacement barrier. The study shows that static quiescent cell monolayers are mechanically poised for motility, and it identifies global stress amplification as a mechanism for overcoming motility restrictions in confined confluent cell monolayers." @default.
- W3217507071 created "2021-12-06" @default.
- W3217507071 creator A5017381687 @default.
- W3217507071 creator A5020299015 @default.
- W3217507071 creator A5024998704 @default.
- W3217507071 creator A5040249823 @default.
- W3217507071 creator A5051560174 @default.
- W3217507071 creator A5055268607 @default.
- W3217507071 creator A5086512047 @default.
- W3217507071 date "2022-08-01" @default.
- W3217507071 modified "2023-10-18" @default.
- W3217507071 title "Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence" @default.
- W3217507071 cites W1666901150 @default.
- W3217507071 cites W1963583989 @default.
- W3217507071 cites W1964847767 @default.
- W3217507071 cites W1968931043 @default.
- W3217507071 cites W1984484225 @default.
- W3217507071 cites W1992353872 @default.
- W3217507071 cites W1993085259 @default.
- W3217507071 cites W2003444365 @default.
- W3217507071 cites W2011585659 @default.
- W3217507071 cites W2016029650 @default.
- W3217507071 cites W2025419865 @default.
- W3217507071 cites W2028542401 @default.
- W3217507071 cites W2031126348 @default.
- W3217507071 cites W2031896438 @default.
- W3217507071 cites W2040843328 @default.
- W3217507071 cites W2052209192 @default.
- W3217507071 cites W2060119002 @default.
- W3217507071 cites W2074106315 @default.
- W3217507071 cites W2076394578 @default.
- W3217507071 cites W2083393209 @default.
- W3217507071 cites W2091389429 @default.
- W3217507071 cites W2092015664 @default.
- W3217507071 cites W2094098398 @default.
- W3217507071 cites W2110834542 @default.
- W3217507071 cites W2112311198 @default.
- W3217507071 cites W2124186838 @default.
- W3217507071 cites W2139754605 @default.
- W3217507071 cites W2143001044 @default.
- W3217507071 cites W2143464311 @default.
- W3217507071 cites W2160780620 @default.
- W3217507071 cites W2173637151 @default.
- W3217507071 cites W2175332918 @default.
- W3217507071 cites W2184806432 @default.
- W3217507071 cites W2257204829 @default.
- W3217507071 cites W2304754051 @default.
- W3217507071 cites W2342153670 @default.
- W3217507071 cites W2465250101 @default.
- W3217507071 cites W2474539144 @default.
- W3217507071 cites W2513054915 @default.
- W3217507071 cites W2522612544 @default.
- W3217507071 cites W2581589183 @default.
- W3217507071 cites W2593476638 @default.
- W3217507071 cites W2593620662 @default.
- W3217507071 cites W2605362309 @default.
- W3217507071 cites W2782225074 @default.
- W3217507071 cites W2889800002 @default.
- W3217507071 cites W2891109293 @default.
- W3217507071 cites W2911631359 @default.
- W3217507071 cites W2945041308 @default.
- W3217507071 cites W2945076939 @default.
- W3217507071 cites W2954832902 @default.
- W3217507071 cites W2963579838 @default.
- W3217507071 cites W2997944126 @default.
- W3217507071 cites W3025066903 @default.
- W3217507071 cites W3039795571 @default.
- W3217507071 cites W3089738900 @default.
- W3217507071 cites W3092611455 @default.
- W3217507071 cites W3098725301 @default.
- W3217507071 cites W3103368541 @default.
- W3217507071 cites W3105969188 @default.
- W3217507071 cites W3133566862 @default.
- W3217507071 cites W3177286333 @default.
- W3217507071 cites W3201875431 @default.
- W3217507071 cites W39099202 @default.
- W3217507071 cites W4245654886 @default.
- W3217507071 cites W970680158 @default.
- W3217507071 cites W982799556 @default.
- W3217507071 doi "https://doi.org/10.1073/pnas.2201328119" @default.
- W3217507071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35914175" @default.
- W3217507071 hasPublicationYear "2022" @default.
- W3217507071 type Work @default.
- W3217507071 sameAs 3217507071 @default.
- W3217507071 citedByCount "2" @default.
- W3217507071 countsByYear W32175070712023 @default.
- W3217507071 crossrefType "journal-article" @default.
- W3217507071 hasAuthorship W3217507071A5017381687 @default.
- W3217507071 hasAuthorship W3217507071A5020299015 @default.
- W3217507071 hasAuthorship W3217507071A5024998704 @default.
- W3217507071 hasAuthorship W3217507071A5040249823 @default.
- W3217507071 hasAuthorship W3217507071A5051560174 @default.
- W3217507071 hasAuthorship W3217507071A5055268607 @default.
- W3217507071 hasAuthorship W3217507071A5086512047 @default.
- W3217507071 hasBestOaLocation W32175070711 @default.
- W3217507071 hasConcept C12554922 @default.
- W3217507071 hasConcept C1491633281 @default.
- W3217507071 hasConcept C185592680 @default.
- W3217507071 hasConcept C55493867 @default.
- W3217507071 hasConcept C58207958 @default.