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- W3217516843 abstract "Asarum heterotropoides extracts showed strong antibacterial activity against selected phytopathogenic bacteria. Bioguided isolation was conducted to obtain 11 phenanthrene derivatives (1-11), 4 phenylpropanoids (12-15), a flavonoid (16), and a steroid (17), including a new phenanthrene derivative (1). In vitro bioassay results showed that phenanthrene derivatives are the main active components of A. heterotropoides extracts. The new compound aristoloxazine C (1) was found to exhibit outstanding antibacterial activity against Ralstonia solanacearum, Xanthomonas oryzae, Erwinia carolovora, Pseudomonas syringae, and Xanthomonas axonopodis, with MIC values of 0.05, 2.5, 2.5, 5, and 6.25 μg/mL, respectively. These values were significantly higher than that of the positive control, streptomycin sulfate. Aristoloxazine C (1) also demonstrated an excellent control effect on tobacco bacterial wilt. Physiological and biochemical experiments combined with electron microscopy showed that the antibacterial activity of aristoloxazine C (1) was primarily related to the destruction of the bacterial cell wall structure. Thus, aristoloxazine C (1) may have the potential to be used as a template for the development of new bactericides or as a probe for the discovery of new antimicrobial targets." @default.
- W3217516843 created "2021-12-06" @default.
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- W3217516843 date "2021-11-23" @default.
- W3217516843 modified "2023-10-10" @default.
- W3217516843 title "Phenanthrene Derivatives from <i>Asarum heterotropoides</i> Showed Excellent Antibacterial Activity against Phytopathogenic Bacteria" @default.
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- W3217516843 doi "https://doi.org/10.1021/acs.jafc.1c04385" @default.
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