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- W3217520512 abstract "An efficient approach to the synthesis of indolizines and pyrrolo[2,1- a ]isoquinolines based on a domino reaction is described. The reactivity of the derivatives and the structure-activity analysis are carried out in a number of the obtained compounds. We found a hit showing high cytotoxicity on tumor cells (IC 50 = 5.92 ± 0.08 µM) whose cytotoxic effect is comparable to that of the known topoisomerase I inhibitor camptothecin ." @default.
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- W3217520512 date "2021-12-01" @default.
- W3217520512 modified "2023-10-03" @default.
- W3217520512 title "Synthesis and cytotoxicity of novel 1-arylindolizines and 1-arylpyrrolo[2,1-a]isoquinolines" @default.
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- W3217520512 doi "https://doi.org/10.1016/j.tetlet.2021.153552" @default.
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