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- W3217528022 abstract "<b>Background:</b> Exposure to traffic-related air pollution (TRAP) is linked to COPD morbidity and mortality, suggesting airway susceptibility in those with COPD exposed to TRAP. <b>Objective:</b> Evaluate the impact of TRAP exposure on the epithelial transcriptome in human bronchioles. <b>Methods:</b> We recruited healthy never-smokers (NS; N=9), ex-smokers (ES; N=7) with >10 pack-year smoking but not COPD, and GOLD stage 1&2 COPD participants (COPD; N=9). In an order-randomized crossover study, each participant was exposed to diesel exhaust (DE; PM<sub>2.5</sub> concentration of 300 µg/m<sup>3</sup>) and filtered air (control) for 2 hours. 24 hours post-exposure, bronchoscopy was performed to collect endobronchial brushes. PolyA RNA sequencing was performed. <b>Results:</b> DE significantly modulated expression of 35, 131 and 10 genes in NS, ES and COPD epithelium, respectively (Fig 1). The effect of DE on139 genes was significantly modified by COPD status. Differentially expressed genes common to NS and ES were <i>GPX2</i>, <i>PSMC1P1</i> and <i>TRIM16L</i>, and functional enrichment analysis revealed NRF2 pathway activation. <b>Conclusions:</b> Exposure to TRAP, typical of congested urban areas, increases expression of antioxidant genes in the airway epithelium in vivo, and this expression is modified in COPD epithelium." @default.
- W3217528022 created "2021-12-06" @default.
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- W3217528022 date "2021-09-05" @default.
- W3217528022 modified "2023-09-27" @default.
- W3217528022 title "Effects of traffic-related air pollution on airway epithelial transcriptome in older adults with and without COPD: a controlled human exposure study" @default.
- W3217528022 doi "https://doi.org/10.1183/13993003.congress-2021.pa1797" @default.
- W3217528022 hasPublicationYear "2021" @default.
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