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- W3217553653 abstract "The development of selective inhibitors of cyclin dependent kinases 4 and 6 (CDK4/6i) has transformed the management of hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative metastatic breast cancer (BC).1 The addition of a CDK4/6i to endocrine therapy improves response rates, progression-free and overall survival with manageable toxicity.2,3 Consequently, three CDK4/6i, palbociclib, ribociclib, and abemaciclib, have gained regulatory approval for metastatic BC." @default.
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- W3217553653 date "2021-12-01" @default.
- W3217553653 modified "2023-10-04" @default.
- W3217553653 title "Adjuvant abemaciclib for high-risk breast cancer: the story continues" @default.
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- W3217553653 doi "https://doi.org/10.1016/j.annonc.2021.10.214" @default.
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