FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217585246> ?p ?o ?g. }

• W3217585246 endingPage "682" @default.
• W3217585246 startingPage "671" @default.
• W3217585246 abstract "Chromosome 8q gain is associated with poor clinical outcomes in prostate cancer, but the underlying biological mechanisms remain to be clarified. CSN5, a putative androgen receptor (AR) partner that is located on chromosome 8q, is the key subunit of the COP9 signalosome, which deactivates ubiquitin ligases. Deregulation of CSN5 could affect diverse cellular functions that contribute to tumor development, but there has been no comprehensive study of its function in prostate cancer. The clinical significance of CSN5 amplification/overexpression was evaluated in 16 prostate cancer clinical cohorts. Its oncogenic activity was assessed by genetic and pharmacologic perturbations of CSN5 activity in prostate cancer cell lines. The molecular mechanisms of CSN5 function were assessed, as was the efficacy of the CSN5 inhibitor CSN5i-3 in vitro and in vivo. Finally, the transcription cofactor activity of CSN5 in prostate cancer cells was determined. The prognostic significance of CSN5 amplification and overexpression in prostate cancer was independent of MYC amplification. Inhibition of CSN5 inhibited its oncogenic function by targeting AR signaling, DNA repair, multiple oncogenic pathways, and spliceosome regulation. Furthermore, inhibition of CSN5 repressed metabolic pathways, including oxidative phosphorylation and glycolysis in AR-negative prostate cancer cells. Targeting CSN5 with CSN5i-3 showed potent antitumor activity in vitro and in vivo. Importantly, CSN5i-3 synergizes with PARP inhibitors to inhibit prostate cancer cell growth. CSN5 functions as a transcription cofactor to cooperate with multiple transcription factors in prostate cancer. Inhibiting CSN5 strongly attenuates prostate cancer progression and could enhance PARP inhibition efficacy in the treatment of prostate cancer." @default.
• W3217585246 created "2021-12-06" @default.
• W3217585246 creator A5010079764 @default.
• W3217585246 creator A5018914638 @default.
• W3217585246 creator A5031836646 @default.
• W3217585246 creator A5036500285 @default.
• W3217585246 creator A5048014496 @default.
• W3217585246 creator A5048060846 @default.
• W3217585246 creator A5049809483 @default.
• W3217585246 creator A5052676364 @default.
• W3217585246 creator A5056766924 @default.
• W3217585246 creator A5060792750 @default.
• W3217585246 creator A5069334303 @default.
• W3217585246 creator A5080705644 @default.
• W3217585246 creator A5084847927 @default.
• W3217585246 creator A5085414722 @default.
• W3217585246 creator A5086714347 @default.
• W3217585246 date "2021-11-20" @default.
• W3217585246 modified "2023-09-26" @default.
• W3217585246 title "Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer" @default.
• W3217585246 cites W1549203021 @default.
• W3217585246 cites W1883773314 @default.
• W3217585246 cites W1963807140 @default.
• W3217585246 cites W1976022788 @default.
• W3217585246 cites W1976445111 @default.
• W3217585246 cites W1977918192 @default.
• W3217585246 cites W1988031203 @default.
• W3217585246 cites W1998646713 @default.
• W3217585246 cites W2002630364 @default.
• W3217585246 cites W2011957420 @default.
• W3217585246 cites W2022005587 @default.
• W3217585246 cites W2030086669 @default.
• W3217585246 cites W2045589622 @default.
• W3217585246 cites W2052861741 @default.
• W3217585246 cites W2081251804 @default.
• W3217585246 cites W2081365151 @default.
• W3217585246 cites W2095527205 @default.
• W3217585246 cites W2097226696 @default.
• W3217585246 cites W2112877739 @default.
• W3217585246 cites W2114843025 @default.
• W3217585246 cites W2114913629 @default.
• W3217585246 cites W2121023961 @default.
• W3217585246 cites W2123879591 @default.
• W3217585246 cites W2130410032 @default.
• W3217585246 cites W2141255350 @default.
• W3217585246 cites W2148892736 @default.
• W3217585246 cites W2159715390 @default.
• W3217585246 cites W2162147642 @default.
• W3217585246 cites W2169489936 @default.
• W3217585246 cites W2179708332 @default.
• W3217585246 cites W2431963657 @default.
• W3217585246 cites W2461244735 @default.
• W3217585246 cites W2613162682 @default.
• W3217585246 cites W2789605409 @default.
• W3217585246 cites W2789900707 @default.
• W3217585246 cites W2890052597 @default.
• W3217585246 cites W2901667276 @default.
• W3217585246 cites W2920191405 @default.
• W3217585246 cites W2937151884 @default.
• W3217585246 cites W2941165855 @default.
• W3217585246 cites W2943849032 @default.
• W3217585246 cites W2944403040 @default.
• W3217585246 cites W2967333631 @default.
• W3217585246 cites W2991319487 @default.
• W3217585246 cites W3008961309 @default.
• W3217585246 cites W3010407329 @default.
• W3217585246 cites W3014482292 @default.
• W3217585246 cites W3023432511 @default.
• W3217585246 cites W3089079164 @default.
• W3217585246 cites W3132330467 @default.
• W3217585246 doi "https://doi.org/10.1038/s41388-021-02118-4" @default.
• W3217585246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34802033" @default.
• W3217585246 hasPublicationYear "2021" @default.
• W3217585246 type Work @default.
• W3217585246 sameAs 3217585246 @default.
• W3217585246 citedByCount "8" @default.
• W3217585246 countsByYear W32175852462021 @default.
• W3217585246 countsByYear W32175852462022 @default.
• W3217585246 countsByYear W32175852462023 @default.
• W3217585246 crossrefType "journal-article" @default.
• W3217585246 hasAuthorship W3217585246A5010079764 @default.
• W3217585246 hasAuthorship W3217585246A5018914638 @default.
• W3217585246 hasAuthorship W3217585246A5031836646 @default.
• W3217585246 hasAuthorship W3217585246A5036500285 @default.
• W3217585246 hasAuthorship W3217585246A5048014496 @default.
• W3217585246 hasAuthorship W3217585246A5048060846 @default.
• W3217585246 hasAuthorship W3217585246A5049809483 @default.
• W3217585246 hasAuthorship W3217585246A5052676364 @default.
• W3217585246 hasAuthorship W3217585246A5056766924 @default.
• W3217585246 hasAuthorship W3217585246A5060792750 @default.
• W3217585246 hasAuthorship W3217585246A5069334303 @default.
• W3217585246 hasAuthorship W3217585246A5080705644 @default.
• W3217585246 hasAuthorship W3217585246A5084847927 @default.
• W3217585246 hasAuthorship W3217585246A5085414722 @default.
• W3217585246 hasAuthorship W3217585246A5086714347 @default.
• W3217585246 hasBestOaLocation W32175852462 @default.
• W3217585246 hasConcept C104292427 @default.
• W3217585246 hasConcept C104317684 @default.

• next