FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217589610> ?p ?o ?g. }

• W3217589610 endingPage "162" @default.
• W3217589610 startingPage "141" @default.
• W3217589610 abstract "One hundred years have passed since Warburg discovered alterations in cancer metabolism, more than 70 years since Sidney Farber introduced anti-folates that transformed the treatment of childhood leukaemia, and 20 years since metabolism was linked to oncogenes. However, progress in targeting cancer metabolism therapeutically in the past decade has been limited. Only a few metabolism-based drugs for cancer have been successfully developed, some of which are in — or en route to — clinical trials. Strategies for targeting the intrinsic metabolism of cancer cells often did not account for the metabolism of non-cancer stromal and immune cells, which have pivotal roles in tumour progression and maintenance. By considering immune cell metabolism and the clinical manifestations of inborn errors of metabolism, it may be possible to isolate undesirable off-tumour, on-target effects of metabolic drugs during their development. Hence, the conceptual framework for drug design must consider the metabolic vulnerabilities of non-cancer cells in the tumour immune microenvironment, as well as those of cancer cells. In this Review, we cover the recent developments, notable milestones and setbacks in targeting cancer metabolism, and discuss the way forward for the field. Despite the link between metabolism and oncogenes, very few metabolism-based drugs for cancer have been successfully developed. This Review covers the setbacks and recent developments in targeting cancer metabolism, and discusses the path forward for the field." @default.
• W3217589610 created "2021-12-06" @default.
• W3217589610 creator A5000153144 @default.
• W3217589610 creator A5006901424 @default.
• W3217589610 creator A5016122970 @default.
• W3217589610 creator A5067716685 @default.
• W3217589610 date "2021-12-03" @default.
• W3217589610 modified "2023-10-17" @default.
• W3217589610 title "Targeting cancer metabolism in the era of precision oncology" @default.
• W3217589610 cites W1247621250 @default.
• W3217589610 cites W1838945435 @default.
• W3217589610 cites W1932780354 @default.
• W3217589610 cites W1963638269 @default.
• W3217589610 cites W1966099909 @default.
• W3217589610 cites W1972254548 @default.
• W3217589610 cites W1975215468 @default.
• W3217589610 cites W1980181091 @default.
• W3217589610 cites W1982233059 @default.
• W3217589610 cites W1982318323 @default.
• W3217589610 cites W1983107759 @default.
• W3217589610 cites W1989273117 @default.
• W3217589610 cites W2002583208 @default.
• W3217589610 cites W2003260126 @default.
• W3217589610 cites W2004574994 @default.
• W3217589610 cites W2009408852 @default.
• W3217589610 cites W2009999719 @default.
• W3217589610 cites W2012442095 @default.
• W3217589610 cites W2017007251 @default.
• W3217589610 cites W2025265597 @default.
• W3217589610 cites W2036659083 @default.
• W3217589610 cites W2038009564 @default.
• W3217589610 cites W2038652783 @default.
• W3217589610 cites W2042921832 @default.
• W3217589610 cites W2044515618 @default.
• W3217589610 cites W2045570288 @default.
• W3217589610 cites W2046858377 @default.
• W3217589610 cites W2051181260 @default.
• W3217589610 cites W2056174640 @default.
• W3217589610 cites W2058218780 @default.
• W3217589610 cites W2059010575 @default.
• W3217589610 cites W2063229165 @default.
• W3217589610 cites W2066800748 @default.
• W3217589610 cites W2066808338 @default.
• W3217589610 cites W2067337288 @default.
• W3217589610 cites W2068812060 @default.
• W3217589610 cites W207053144 @default.
• W3217589610 cites W2072019190 @default.
• W3217589610 cites W2072223844 @default.
• W3217589610 cites W2072635345 @default.
• W3217589610 cites W2073387842 @default.
• W3217589610 cites W2074873270 @default.
• W3217589610 cites W2078770291 @default.
• W3217589610 cites W2082135892 @default.
• W3217589610 cites W2086222405 @default.
• W3217589610 cites W2090415246 @default.
• W3217589610 cites W2090846942 @default.
• W3217589610 cites W2093985232 @default.
• W3217589610 cites W2095383299 @default.
• W3217589610 cites W2096404967 @default.
• W3217589610 cites W2097259163 @default.
• W3217589610 cites W2099613995 @default.
• W3217589610 cites W2105250121 @default.
• W3217589610 cites W2107975811 @default.
• W3217589610 cites W2109447452 @default.
• W3217589610 cites W2112861594 @default.
• W3217589610 cites W2121593996 @default.
• W3217589610 cites W2129050532 @default.
• W3217589610 cites W2132117833 @default.
• W3217589610 cites W2136014653 @default.
• W3217589610 cites W2138202978 @default.
• W3217589610 cites W2139466117 @default.
• W3217589610 cites W2141467202 @default.
• W3217589610 cites W2141732292 @default.
• W3217589610 cites W2142239579 @default.
• W3217589610 cites W2143394009 @default.
• W3217589610 cites W2149441684 @default.
• W3217589610 cites W2152358473 @default.
• W3217589610 cites W2164355096 @default.
• W3217589610 cites W2169626949 @default.
• W3217589610 cites W2172697812 @default.
• W3217589610 cites W2193134010 @default.
• W3217589610 cites W2266126951 @default.
• W3217589610 cites W2266570683 @default.
• W3217589610 cites W2295060570 @default.
• W3217589610 cites W2297834160 @default.
• W3217589610 cites W2298914518 @default.
• W3217589610 cites W2310326452 @default.
• W3217589610 cites W2314067388 @default.
• W3217589610 cites W2328999771 @default.
• W3217589610 cites W2343452853 @default.
• W3217589610 cites W2395626624 @default.
• W3217589610 cites W2395662745 @default.
• W3217589610 cites W2409153565 @default.
• W3217589610 cites W2418504051 @default.
• W3217589610 cites W2488460578 @default.
• W3217589610 cites W2488631284 @default.
• W3217589610 cites W2503851771 @default.
• W3217589610 cites W2513280988 @default.

• next