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• W3217599642 abstract "Approximately 20% of patients with transient abnormal myelopoiesis (TAM) die due to hepatic or multiorgan failure. To identify potential new treatments for TAM, we performed in vitro drug sensitivity testing (DST) using the peripheral blood samples of eight patients with TAM. DST screened 41 agents for cytotoxic properties against TAM blasts. Compared with the reference samples of healthy subjects, TAM blasts were more sensitive to glucocorticoids, the mitogen-activated protein kinase kinase (MAP2K) inhibitor trametinib, and cytarabine. Our present results support the therapeutic potential of glucocorticoids and the role of the RAS/MAP2K signalling pathway in TAM pathogenesis." @default.
• W3217599642 created "2021-12-06" @default.
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• W3217599642 date "2021-11-23" @default.
• W3217599642 modified "2023-10-01" @default.
• W3217599642 title "Using the <i>in vitro</i> drug sensitivity test to identify candidate treatments for transient abnormal myelopoiesis" @default.
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• W3217599642 doi "https://doi.org/10.1111/bjh.17970" @default.
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