FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217607978> ?p ?o ?g. }

• W3217607978 endingPage "131999" @default.
• W3217607978 startingPage "131999" @default.
• W3217607978 abstract "Naturally occurring terpene core compounds have been used extensively in both pharmaceutical and cosmetic industry. However, since chirality of these compounds has profound influence on the level of their bioactivity, the aim of the present study was to assess broad spectrum activities of four possible stereoisomers of monoterpene alcohol verbenol and both enantiomers of monoterpene ketone verbenone. Antimicrobial activity was evaluated against different bacterial and fungal strains of clinical relevance. Tested compounds exhibited antibacterial activity within MICs range of 0.6–2.5 mg mL−1, antifungal activity within MICs range of 0.08–0.6 mg mL−1, and anticandidal activity with MICs 0.3–1.2 mg mL−1. While there was no difference in antibacterial activity between the enantiomers of verbenone, this was not the case with tested verbenol enantiomers. Furthermore, the compounds expressed no cytotoxicity to human keratinocyte cell line HaCaT at the tested concentrations. Interestingly, compounds contributed to the downregulation of interleukin IL-6 levels in HaCaT cells exposed to bacterial agent Staphylococcus lugdunensis. According to our knowledge, this study is the first that comparatively describes biological activities of stereoisomers of verbenol and enantiomers of verbenone. Current findings highlighted the importance of stereochemical purity of monoterpenoids in relation to their unique biological features." @default.
• W3217607978 created "2021-12-06" @default.
• W3217607978 creator A5018546596 @default.
• W3217607978 creator A5018667343 @default.
• W3217607978 creator A5040517622 @default.
• W3217607978 creator A5060592354 @default.
• W3217607978 creator A5068615210 @default.
• W3217607978 creator A5087367073 @default.
• W3217607978 date "2022-03-01" @default.
• W3217607978 modified "2023-09-27" @default.
• W3217607978 title "Individual stereoisomers of verbenol and verbenone express bioactive features" @default.
• W3217607978 cites W1563110019 @default.
• W3217607978 cites W1986970926 @default.
• W3217607978 cites W1999497169 @default.
• W3217607978 cites W2015368195 @default.
• W3217607978 cites W2043165163 @default.
• W3217607978 cites W2058303382 @default.
• W3217607978 cites W207556588 @default.
• W3217607978 cites W2075780404 @default.
• W3217607978 cites W2081081183 @default.
• W3217607978 cites W2084702397 @default.
• W3217607978 cites W2092061024 @default.
• W3217607978 cites W2098127312 @default.
• W3217607978 cites W2132767279 @default.
• W3217607978 cites W2148658155 @default.
• W3217607978 cites W2316428856 @default.
• W3217607978 cites W2425948998 @default.
• W3217607978 cites W2569769014 @default.
• W3217607978 cites W2575030453 @default.
• W3217607978 cites W2577195602 @default.
• W3217607978 cites W2734647920 @default.
• W3217607978 cites W2735092774 @default.
• W3217607978 cites W2761818796 @default.
• W3217607978 cites W2775176611 @default.
• W3217607978 cites W2801338277 @default.
• W3217607978 cites W2926099237 @default.
• W3217607978 cites W2967581379 @default.
• W3217607978 cites W3036216179 @default.
• W3217607978 cites W3041107962 @default.
• W3217607978 cites W3087901656 @default.
• W3217607978 cites W3088505225 @default.
• W3217607978 cites W3118980126 @default.
• W3217607978 cites W3123006638 @default.
• W3217607978 cites W84185627 @default.
• W3217607978 doi "https://doi.org/10.1016/j.molstruc.2021.131999" @default.
• W3217607978 hasPublicationYear "2022" @default.
• W3217607978 type Work @default.
• W3217607978 sameAs 3217607978 @default.
• W3217607978 citedByCount "3" @default.
• W3217607978 countsByYear W32176079782022 @default.
• W3217607978 countsByYear W32176079782023 @default.
• W3217607978 crossrefType "journal-article" @default.
• W3217607978 hasAuthorship W3217607978A5018546596 @default.
• W3217607978 hasAuthorship W3217607978A5018667343 @default.
• W3217607978 hasAuthorship W3217607978A5040517622 @default.
• W3217607978 hasAuthorship W3217607978A5060592354 @default.
• W3217607978 hasAuthorship W3217607978A5068615210 @default.
• W3217607978 hasAuthorship W3217607978A5087367073 @default.
• W3217607978 hasConcept C118995209 @default.
• W3217607978 hasConcept C178790620 @default.
• W3217607978 hasConcept C185592680 @default.
• W3217607978 hasConcept C202751555 @default.
• W3217607978 hasConcept C2776211264 @default.
• W3217607978 hasConcept C2777671706 @default.
• W3217607978 hasConcept C2780104969 @default.
• W3217607978 hasConcept C44937612 @default.
• W3217607978 hasConcept C486523 @default.
• W3217607978 hasConcept C4937899 @default.
• W3217607978 hasConcept C523546767 @default.
• W3217607978 hasConcept C54355233 @default.
• W3217607978 hasConcept C55493867 @default.
• W3217607978 hasConcept C71240020 @default.
• W3217607978 hasConcept C86803240 @default.
• W3217607978 hasConceptScore W3217607978C118995209 @default.
• W3217607978 hasConceptScore W3217607978C178790620 @default.
• W3217607978 hasConceptScore W3217607978C185592680 @default.
• W3217607978 hasConceptScore W3217607978C202751555 @default.
• W3217607978 hasConceptScore W3217607978C2776211264 @default.
• W3217607978 hasConceptScore W3217607978C2777671706 @default.
• W3217607978 hasConceptScore W3217607978C2780104969 @default.
• W3217607978 hasConceptScore W3217607978C44937612 @default.
• W3217607978 hasConceptScore W3217607978C486523 @default.
• W3217607978 hasConceptScore W3217607978C4937899 @default.
• W3217607978 hasConceptScore W3217607978C523546767 @default.
• W3217607978 hasConceptScore W3217607978C54355233 @default.
• W3217607978 hasConceptScore W3217607978C55493867 @default.
• W3217607978 hasConceptScore W3217607978C71240020 @default.
• W3217607978 hasConceptScore W3217607978C86803240 @default.
• W3217607978 hasFunder F4320309920 @default.
• W3217607978 hasFunder F4320311365 @default.
• W3217607978 hasFunder F4320322729 @default.
• W3217607978 hasLocation W32176079781 @default.
• W3217607978 hasOpenAccess W3217607978 @default.
• W3217607978 hasPrimaryLocation W32176079781 @default.
• W3217607978 hasRelatedWork W108295400 @default.
• W3217607978 hasRelatedWork W2030915119 @default.
• W3217607978 hasRelatedWork W2137204070 @default.
• W3217607978 hasRelatedWork W2151330911 @default.

• next