Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217608077> ?p ?o ?g. }
- W3217608077 abstract "Our study investigates the potential of diffusion MRI (dMRI), including diffusion tensor imaging (DTI), fixel-based analysis (FBA) and neurite orientation dispersion and density imaging (NODDI), to detect microstructural tissue abnormalities in rats after mild traumatic brain injury (mTBI). The brains of sham-operated and mTBI rats 35 days after lateral fluid percussion injury were imaged ex vivo in a 11.7-T scanner. Voxel-based analyses of DTI-, fixel- and NODDI-based metrics detected extensive tissue changes in directly affected brain areas close to the primary injury, and more importantly, also in distal areas connected to primary injury and indirectly affected by the secondary injury mechanisms. Histology revealed ongoing axonal abnormalities and inflammation, 35 days after the injury, in the brain areas highlighted in the group analyses. Fractional anisotropy (FA), fiber density (FD) and fiber density and fiber bundle cross-section (FDC) showed similar pattern of significant areas throughout the brain; however, FA showed more significant voxels in gray matter areas, while FD and FDC in white matter areas, and orientation dispersion index (ODI) in areas most damage based on histology. Region-of-interest (ROI)-based analyses on dMRI maps and histology in selected brain regions revealed that the changes in MRI parameters could be attributed to both alterations in myelinated fiber bundles and increased cellularity. This study demonstrates that the combination of dMRI methods can provide a more complete insight into the microstructural alterations in white and gray matter after mTBI, which may aid diagnosis and prognosis following a mild brain injury." @default.
- W3217608077 created "2021-12-06" @default.
- W3217608077 creator A5007108693 @default.
- W3217608077 creator A5008075513 @default.
- W3217608077 creator A5019751091 @default.
- W3217608077 creator A5021572716 @default.
- W3217608077 creator A5034757327 @default.
- W3217608077 creator A5040293704 @default.
- W3217608077 creator A5048214966 @default.
- W3217608077 creator A5065702208 @default.
- W3217608077 date "2021-11-26" @default.
- W3217608077 modified "2023-09-27" @default.
- W3217608077 title "Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury" @default.
- W3217608077 cites W1582730964 @default.
- W3217608077 cites W1964802316 @default.
- W3217608077 cites W1965894642 @default.
- W3217608077 cites W1975017507 @default.
- W3217608077 cites W1984861119 @default.
- W3217608077 cites W1988822817 @default.
- W3217608077 cites W1988954604 @default.
- W3217608077 cites W1990022633 @default.
- W3217608077 cites W1993445932 @default.
- W3217608077 cites W1995138343 @default.
- W3217608077 cites W1998081288 @default.
- W3217608077 cites W2001611992 @default.
- W3217608077 cites W2010125850 @default.
- W3217608077 cites W2019836674 @default.
- W3217608077 cites W2019925358 @default.
- W3217608077 cites W2027556635 @default.
- W3217608077 cites W2032254014 @default.
- W3217608077 cites W2033809837 @default.
- W3217608077 cites W2034252184 @default.
- W3217608077 cites W2045442080 @default.
- W3217608077 cites W2046557060 @default.
- W3217608077 cites W2053999216 @default.
- W3217608077 cites W2072391600 @default.
- W3217608077 cites W2075074515 @default.
- W3217608077 cites W2075900572 @default.
- W3217608077 cites W2080198834 @default.
- W3217608077 cites W2082182286 @default.
- W3217608077 cites W2083249651 @default.
- W3217608077 cites W2092899809 @default.
- W3217608077 cites W2104731959 @default.
- W3217608077 cites W2108243930 @default.
- W3217608077 cites W2109806433 @default.
- W3217608077 cites W2110065044 @default.
- W3217608077 cites W2117340355 @default.
- W3217608077 cites W2117987496 @default.
- W3217608077 cites W2122662954 @default.
- W3217608077 cites W2127635814 @default.
- W3217608077 cites W2137679584 @default.
- W3217608077 cites W2141188392 @default.
- W3217608077 cites W2144537780 @default.
- W3217608077 cites W2147927529 @default.
- W3217608077 cites W2155276408 @default.
- W3217608077 cites W2157723935 @default.
- W3217608077 cites W2160112896 @default.
- W3217608077 cites W2165020904 @default.
- W3217608077 cites W2170424940 @default.
- W3217608077 cites W2172006631 @default.
- W3217608077 cites W2346471028 @default.
- W3217608077 cites W239929985 @default.
- W3217608077 cites W2520744072 @default.
- W3217608077 cites W2565283532 @default.
- W3217608077 cites W2593065467 @default.
- W3217608077 cites W2598130805 @default.
- W3217608077 cites W2608738548 @default.
- W3217608077 cites W2626287694 @default.
- W3217608077 cites W2745601452 @default.
- W3217608077 cites W2753663815 @default.
- W3217608077 cites W2768153053 @default.
- W3217608077 cites W2791758041 @default.
- W3217608077 cites W2803364018 @default.
- W3217608077 cites W2887310643 @default.
- W3217608077 cites W2889219133 @default.
- W3217608077 cites W2894578063 @default.
- W3217608077 cites W2905657554 @default.
- W3217608077 cites W2944229063 @default.
- W3217608077 cites W2951032685 @default.
- W3217608077 cites W2962681100 @default.
- W3217608077 cites W2968783567 @default.
- W3217608077 cites W2970898057 @default.
- W3217608077 cites W3004325869 @default.
- W3217608077 cites W3013886781 @default.
- W3217608077 cites W3014906913 @default.
- W3217608077 cites W3019036807 @default.
- W3217608077 cites W3026261060 @default.
- W3217608077 cites W3047684611 @default.
- W3217608077 cites W3049304068 @default.
- W3217608077 cites W3080756392 @default.
- W3217608077 cites W3096987701 @default.
- W3217608077 cites W3097783009 @default.
- W3217608077 cites W3099660684 @default.
- W3217608077 cites W3102650487 @default.
- W3217608077 cites W3112657076 @default.
- W3217608077 cites W3138181658 @default.
- W3217608077 cites W3156523967 @default.
- W3217608077 doi "https://doi.org/10.3389/fnins.2021.746214" @default.
- W3217608077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34899158" @default.
- W3217608077 hasPublicationYear "2021" @default.