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- W3217614897 abstract "RP-HPLC method was developed for the estimation of Lisinopril and Hydrochlorothiazide in tablet dosage form with the help of Quality by Design (QbD) approaches. In this method concentration of each drug was obtained by using the absorptivity values calculated for drug wavelength 226.0 nm and solving the equation. The RP-HPLC method was performed C18-(100mm x 4.6 mm,)2.5 μm particle size in gradient mode, and the sample was analysed using methanol 45.0 ml and 55.0 ml (pH 3.3 0.05% OPA with TEA) as a mobile phase at a flow rate of 0.8 ml/min and detection at nm. By the retention time for Lisinopril and Hydrochlorothiazide found 3.39 and 4.59 min respectively. Validation related the method is specific, rapid, accurate, precise, reliable, and reproducible. Calibration plots by both HPLC were linear over the 5-25 and 12.5-62.5 μg/ml for Lisinopril and Hydrochlorothiazide respectively, and recoveries from tablet dosage form were between 99.02 and 100.00 %. The method can be used for routine of the quality control in pharmaceuticals. The degradation profiling of Lisinopril and Hydrochlorothiazide were also carried out." @default.
- W3217614897 created "2021-12-06" @default.
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- W3217614897 date "2021-11-27" @default.
- W3217614897 modified "2023-09-23" @default.
- W3217614897 title "Degradation Profiling of Lisinopril and Hydrochlorothiazide by RP- HPLC method with QbD Approach" @default.
- W3217614897 cites W2609452135 @default.
- W3217614897 doi "https://doi.org/10.52711/2231-5675.2021.00046" @default.
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