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• W3217627172 endingPage "1544" @default.
• W3217627172 startingPage "1544" @default.
• W3217627172 abstract "Antibiotic therapy and photodynamic therapy (PDT) are commonly used to treat bacterial infections. Unfortunately, these methods are often ineffective. Therefore, agents that could effectively support antibiotic therapy and PDT in the inactivation of pathogens are being sought. Phytotherapy seems to be a good solution. The aim of the current research was to examine whether Polypodium vulgare extract (PvE) would improve the effectiveness of PDT and ciprofloxacin (CIP), an antibiotic that is commonly used to treat urinary tract infections in humans. UHPLC-MS analysis was performed to establish the PvE content. Chlorin e6 has been used as a photosensitizer in the PDT method. Biofilm production was established using the spectrophotometric method. The live cell count in planktonic and biofilm consortia was determined with the microdilution method and DAPI staining. The decrease of the bacterial survival, biofilm mass synthesis, and morphological changes of the bacteria under the combined treatments: PDT+PvE and CIP+PvE was noted. The results clearly indicate that the PvE can be used as a good agent for improving the efficacy of both PDT and the CIP activity to inactivate uropathogenic Escherichia coli strains. The obtained results are of particular value in the era of widespread and still-increasing drug resistance among bacterial pathogens." @default.
• W3217627172 created "2021-12-06" @default.
• W3217627172 creator A5018483199 @default.
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• W3217627172 date "2021-11-25" @default.
• W3217627172 modified "2023-10-17" @default.
• W3217627172 title "The Enhancement of the Photodynamic Therapy and Ciprofloxacin Activity against Uropathogenic Escherichia coli Strains by Polypodium vulgare Rhizome Aqueous Extract" @default.
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• W3217627172 doi "https://doi.org/10.3390/pathogens10121544" @default.
• W3217627172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34959499" @default.
• W3217627172 hasPublicationYear "2021" @default.
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