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• W3217627552 endingPage "101296" @default.
• W3217627552 startingPage "101296" @default.
• W3217627552 abstract "Tumor treating fields (TTFields)-an intermediate-frequency, electric field therapy-has emerged as a promising alternative therapy for the treatment of solid cancers. Since the first publication describing the anticancer effects of TTFields in 2004 there have been numerous follow-up studies by other groups, either to confirm the efficacy of TTFields or to study the primary mechanism of interaction. The overwhelming conclusion from these in vitro studies is that TTFields reduce the viability of aggressively replicating cell lines. However, there is still speculation as to the primary mechanism for this effect; moreover, observations both in vitro and in vivo of inhibited migration and metastases have been made, which may be unrelated to the originally proposed hypothesis of replication stress. Adding to this, the in vivo environment is much more complex spatially, structurally, and involves intricate networks of cell signaling, all of which could change the efficacy of TTFields in the same way pharmaceutical interventions often struggle transitioning in vivo. Despite this, TTFields have shown promise in clinical practice on multiple cancer types, which begs the question: has the primary mechanism carried over from in vitro to in vivo or are there new mechanisms at play? The goal of this review is to highlight the current proposed mechanism of action of TTFields based primarily on in vitro experiments and animal models, provide a summary of the clinical efficacy of TTFields, and finally, propose future directions of research to identify all possible mechanisms in vivo utilizing novel tumor-on-a-chip platforms." @default.
• W3217627552 created "2021-12-06" @default.
• W3217627552 creator A5084923675 @default.
• W3217627552 creator A5086522219 @default.
• W3217627552 creator A5086584544 @default.
• W3217627552 date "2022-01-01" @default.
• W3217627552 modified "2023-10-18" @default.
• W3217627552 title "Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers" @default.
• W3217627552 cites W1514820219 @default.
• W3217627552 cites W1605126740 @default.
• W3217627552 cites W1899509494 @default.
• W3217627552 cites W1964287957 @default.
• W3217627552 cites W1982834516 @default.
• W3217627552 cites W2013594083 @default.
• W3217627552 cites W2020220911 @default.
• W3217627552 cites W2033278321 @default.
• W3217627552 cites W2041236572 @default.
• W3217627552 cites W2049157316 @default.
• W3217627552 cites W2049656714 @default.
• W3217627552 cites W2077340768 @default.
• W3217627552 cites W2087597921 @default.
• W3217627552 cites W2098950184 @default.
• W3217627552 cites W2099951637 @default.
• W3217627552 cites W2100384057 @default.
• W3217627552 cites W2103537491 @default.
• W3217627552 cites W2111838337 @default.
• W3217627552 cites W2134667653 @default.
• W3217627552 cites W2149659626 @default.
• W3217627552 cites W2149768128 @default.
• W3217627552 cites W2151418338 @default.
• W3217627552 cites W2155073814 @default.
• W3217627552 cites W2156826863 @default.
• W3217627552 cites W2165480504 @default.
• W3217627552 cites W2168283594 @default.
• W3217627552 cites W2174255059 @default.
• W3217627552 cites W2196065821 @default.
• W3217627552 cites W2205491921 @default.
• W3217627552 cites W2215044613 @default.
• W3217627552 cites W2293801493 @default.
• W3217627552 cites W2295491540 @default.
• W3217627552 cites W2339359864 @default.
• W3217627552 cites W2441337908 @default.
• W3217627552 cites W2510046850 @default.
• W3217627552 cites W2513363024 @default.
• W3217627552 cites W2516444448 @default.
• W3217627552 cites W2517404177 @default.
• W3217627552 cites W2519932552 @default.
• W3217627552 cites W2547557999 @default.
• W3217627552 cites W2549115354 @default.
• W3217627552 cites W2549188558 @default.
• W3217627552 cites W2569858041 @default.
• W3217627552 cites W2597844539 @default.
• W3217627552 cites W2601868035 @default.
• W3217627552 cites W2603622659 @default.
• W3217627552 cites W2739037777 @default.
• W3217627552 cites W2778267282 @default.
• W3217627552 cites W2781425532 @default.
• W3217627552 cites W2791134790 @default.
• W3217627552 cites W2791464582 @default.
• W3217627552 cites W2791685368 @default.
• W3217627552 cites W2792993918 @default.
• W3217627552 cites W2884166908 @default.
• W3217627552 cites W2885451988 @default.
• W3217627552 cites W2887966780 @default.
• W3217627552 cites W2890938824 @default.
• W3217627552 cites W2894570671 @default.
• W3217627552 cites W2896382962 @default.
• W3217627552 cites W2897336072 @default.
• W3217627552 cites W2897589691 @default.
• W3217627552 cites W2899503349 @default.
• W3217627552 cites W2902560780 @default.
• W3217627552 cites W2909570965 @default.
• W3217627552 cites W2913210263 @default.
• W3217627552 cites W2914067845 @default.
• W3217627552 cites W2936516935 @default.
• W3217627552 cites W2945428285 @default.
• W3217627552 cites W2948870515 @default.
• W3217627552 cites W2953410222 @default.
• W3217627552 cites W2953504750 @default.
• W3217627552 cites W2968196231 @default.
• W3217627552 cites W2971543513 @default.
• W3217627552 cites W2979167290 @default.
• W3217627552 cites W2979984433 @default.
• W3217627552 cites W2981250206 @default.
• W3217627552 cites W2981658574 @default.
• W3217627552 cites W2982046850 @default.
• W3217627552 cites W2990939926 @default.
• W3217627552 cites W3008709031 @default.
• W3217627552 cites W3009856270 @default.
• W3217627552 cites W3031388342 @default.
• W3217627552 cites W3041951665 @default.
• W3217627552 cites W3087102249 @default.
• W3217627552 cites W3092664852 @default.
• W3217627552 cites W3119005666 @default.
• W3217627552 cites W3183523147 @default.
• W3217627552 cites W4211010502 @default.
• W3217627552 cites W4306173260 @default.
• W3217627552 doi "https://doi.org/10.1016/j.tranon.2021.101296" @default.

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