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• W3217631472 abstract "See Clinical Research on Page 28 See Clinical Research on Page 28 Women with advanced CKD are often advised to postpone pregnancy until after kidney transplant owing to improved fertility, higher quality of life, and lower pregnancy complication rates compared with those receiving dialysis.1Piccoli G.B. Minelli F. Versino E. et al.Pregnancy in dialysis patients in the new millennium: a systematic review and meta-regression analysis correlating dialysis schedules and pregnancy outcomes.Nephrol Dial Transplant. 2016; 31: 1915-1934https://doi.org/10.1093/ndt/gfv395Crossref PubMed Scopus (95) Google Scholar,S1 Nevertheless, pregnancy after kidney transplant remains at high risk for adverse outcomes, with preeclampsia occurring in 25% to 30% of women and preterm birth occurring at a mean gestational age of 35 to 36 weeks.2Shah S. Venkatesan R.L. Gupta A. et al.Pregnancy outcomes in women with kidney transplant: meta-analysis and systematic review.BMC Nephrol. 2019; 20: 24https://doi.org/10.1186/s12882-019-1213-5Crossref PubMed Scopus (49) Google Scholar,S2 In addition to the impact of a kidney transplant on maternal and fetal outcomes, the impact of pregnancy on graft loss is of serious concern to both women with advanced CKD anticipating transplant and those with functioning kidney transplants pursuing preconception counseling.S3 Time to conception may play a role, as Rose et al.3Rose C. Gill J. Zalunardo N. et al.Timing of pregnancy after kidney transplantation and risk of allograft failure.Am J Transplant. 2016; 16: 2360-2367https://doi.org/10.1111/ajt.13773Crossref PubMed Scopus (40) Google Scholar found a higher rate of death-censored graft loss when pregnancy occurred within 1 to 2 years after transplant. If pregnancy is associated with long-term graft loss, some women with advanced CKD may choose to pursue pregnancy with their native kidneys—understanding that dialysis could be used as a bridge to subsequent transplant postpartum (albeit this is most easily achieved with a living donor on standby). In women with a functioning kidney transplant, knowledge of graft loss owing to pregnancy may affect their decision to pursue pregnancy, or perhaps consider alternative options, such as adoption or a gestational carrier.S4 In this multicenter retrospective study, Kattah et al.4Kattah A.G. Albadri S. Alexander M.P. et al.Impact of pregnancy on GFR decline and kidney histology in kidney transplant recipients.Kidney Int Rep. 2022; 7: 28-35https://doi.org/10.1016/j.ekir.2021.10.010Abstract Full Text Full Text PDF Scopus (1) Google Scholar set out to evaluate whether pregnancy contributed to graft loss over time. Uniquely, the authors used both protocol and indicated allograft biopsies, performed up to 10 years post-transplant, to also investigate the impact of pregnancy on allograft histology. To evaluate glomerular filtration rate (GFR) decline, the authors were able to examine >36,000 serum creatinine values from 816 women of childbearing age at the time of transplant. After pregnancy, they found a statistically significant increase in the rate of estimated GFR decline per year of −2.4 ml/min per 1.73 m2 in women who had been pregnant compared with −1.9 ml/min per 1.73 m2 in those not pregnant (P < 0.001). It should be noted though that pregnancies occurred at a median of 59.5 months post-transplant, and it is unclear whether the time from transplant is taken into account when comparing the rate of decline in these 2 groups. Conversely, even with an accelerated reduction in estimated GFR over time, the authors did not find a difference in graft loss, or loss of >50% of GFR over a median of 8-year follow-up time. This is somewhat disconcerting and clearly may require longer follow-up to fully elucidate the impact of pregnancy on the allograft. Nevertheless, a recent meta-analysis found similar results—including a marginally increased serum creatinine level (0.18 mg/dl, 95% CI 0.05–0.32, P = 0.01) within 2 years postpartum without risk for long-term graft loss from >10 years of follow-up data.5van Buren M.C. Schellekens A. Groenhof T.K.J. et al.Long-term graft survival and graft function following pregnancy in kidney transplant recipients: a systematic review and meta-analysis.Transplantation. 2020; 104: 1675-1685https://doi.org/10.1097/TP.0000000000003026Crossref PubMed Scopus (14) Google Scholar Previous studies have identified preconception hypertension, creatinine level >1.5 mg/dl, and proteinuria as risk factors associated with graft loss.2Shah S. Venkatesan R.L. Gupta A. et al.Pregnancy outcomes in women with kidney transplant: meta-analysis and systematic review.BMC Nephrol. 2019; 20: 24https://doi.org/10.1186/s12882-019-1213-5Crossref PubMed Scopus (49) Google Scholar,5van Buren M.C. Schellekens A. Groenhof T.K.J. et al.Long-term graft survival and graft function following pregnancy in kidney transplant recipients: a systematic review and meta-analysis.Transplantation. 2020; 104: 1675-1685https://doi.org/10.1097/TP.0000000000003026Crossref PubMed Scopus (14) Google Scholar,S5 Surprisingly, pre-existing hypertension and GFR <60 ml/min were not significant risk factors for loss of GFR in this cohort, but severity of disease is not well described and GFR may have been clustered at approximately 60 ml/min. Significant preconception proteinuria level of >300 mg/dl occurred only in 3 women, limiting conclusions that can be drawn from this group, but did seem to contribute to a significantly faster decline in kidney function postpartum. Among 37 women with pregnancies occurring beyond 20 weeks, the authors found a significantly higher vascular fibrous intimal thickening score in 21 postpregnancy biopsies compared with 33 prepregnancy biopsies. This was not accounted for by the time from transplant, or the presence of hypertension at time of conception. The impact of preeclampsia was not fully elucidated given the small sample size; the authors reported that 37% of pregnancies were complicated by preeclampsia, but it is unclear whether higher amount of vascular fibrous intimal thickening occurred after a preeclamptic pregnancy. Reassuringly to our patients, the changes in postpregnancy biopsies were otherwise consistent with features found in allografts over time—namely increased arteriolar hyalinosis, global sclerosis of glomeruli, and interstitial fibrosis/tubular atrophy. Moreover, although glomerulonephritis was the most common cause of end-stage kidney disease before transplant, there was no increased risk of recurrence in the allograft after pregnancy. The potential mechanism for pregnancy-related GFR decline or graft loss among kidney transplant recipients is not well understood. Preeclampsia is well known to cause glomerular endotheliosis that is generally reversed after delivery.6Stillman I.E. Karumanchi S.A. The glomerular injury of preeclampsia.J Am Soc Nephrol. 2007; 18: 2281-2284https://doi.org/10.1681/ASN.2007020255Crossref PubMed Scopus (207) Google Scholar Nevertheless, population-based studies have revealed that a history of preeclampsia is associated with higher incidence of both CKD and end-stage kidney disease and subtle endothelial injury may account for the development of chronic hypertension after preeclampsia.6Stillman I.E. Karumanchi S.A. The glomerular injury of preeclampsia.J Am Soc Nephrol. 2007; 18: 2281-2284https://doi.org/10.1681/ASN.2007020255Crossref PubMed Scopus (207) Google Scholar,7Kristensen J.H. Basit S. Wohlfahrt J. Damholt M.B. Boyd H.A. Pre-eclampsia and risk of later kidney disease: nationwide cohort study.BMJ. 2019; 365: l1516https://doi.org/10.1136/bmj.l1516Crossref PubMed Scopus (43) Google Scholar,S6 In addition, focal segmental glomerular sclerosis is more common in pregnancy-related biopsies compared with controls.8Webster P. Webster L.M. Cook H.T. et al.A multicenter cohort study of histologic findings and long-term outcomes of kidney disease in women who have been pregnant.Clin J Am Soc Nephrol. 2017; 12: 408-416https://doi.org/10.2215/CJN.05610516Crossref PubMed Scopus (10) Google Scholar Given the higher postpregnancy vascular findings, it is imperative to evaluate this outcome within a larger cohort and specifically among women with and without preeclampsia. The impact of aspirin use to prevent preeclampsia should also be evaluated in the kidney transplant recipient population and whether treatment (and/or a dose response) could potentially mitigate these findings. More aggressive blood pressure (BP) management in pregnancy may also be beneficial. Although BP goals in pregnancy for women with CKD generally target a BP level <140/90 mm Hg, we know from the CHIPS trial that aiming for a lower diastolic BP of 85 mm Hg did not increase risk of pregnancy loss and reduced frequency of severe maternal hypertension.9Magee L.A. von Dadelszen P. Rey E. et al.Less-tight versus tight control of hypertension in pregnancy.N Engl J Med. 2015; 372: 407-417https://doi.org/10.1056/NEJMoa1404595Crossref PubMed Scopus (240) Google Scholar Overall, the inclusion of renal histopathology by Kattah et al. provides compelling insight into the potential mechanism of pregnancy-induced GFR decline. Unfortunately, the small sample size limits conclusions that can be drawn on critically important but rare clinical outcomes, including allograft failure and allograft rejection. In addition, the impact of hypertension within pregnancy and development of preeclampsia on allograft histology remains unknown. Until larger and longer-term studies are accomplished, we should reassure our patients that there is no evidence thus far that pregnancy itself contributes significantly to graft loss over time. Kattah et al. add to our preconception counseling to include the potential for a mild, yet statistically significant, GFR decline postpartum and potential chronic vascular changes in the allograft. Women with advanced CKD or a functioning kidney allograft who are contemplating pregnancy must be made aware that the risk of preeclampsia and preterm birth remains substantial in a pregnancy pursued after a kidney transplant. Obstetric care in a multidisciplinary clinic with both nephrology and maternal-fetal medicine is ideal. Low-dose aspirin started after 12 weeks of gestation should be included in their medication armamentarium to help reduce risk of preeclampsia. In addition, preconception optimization of BP and proteinuria, along with stable graft function, remains prudent to reduce adverse maternal/fetal outcomes and potentially lessen GFR decline postpartum. Motherhood is a life goal for many women with CKD, and caring for our patients during this time is both rewarding and fulfilling. Transparency regarding the knowns and unknowns of obstetrical nephrology leads to stronger relationships with our patients as they navigate this often stressful and difficult journey. Although questions remain surrounding the origin and significance of both postpartum GFR decline and vascular changes in the allograft, we applaud Kattah et al. for their use of histopathology to pave the way for larger studies evaluating mechanisms of pregnancy-associated progression of CKD. All the authors declared no competing interests. Download .pdf (.11 MB) Help with pdf files Supplementary References Impact of Pregnancy on GFR Decline and Kidney Histology in Kidney Transplant RecipientsKidney International ReportsVol. 7Issue 1PreviewWomen with advanced kidney disease are advised to wait until after transplant to pursue pregnancy, but the impact of pregnancy on estimated glomerular filtration rate (eGFR) decline and kidney histology is unclear. Full-Text PDF Open Access" @default.
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• W3217631472 title "Pregnancy in Renal Transplant Recipients: Histopathology Provides New Insight" @default.
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