FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217654974> ?p ?o ?g. }

• W3217654974 endingPage "6996" @default.
• W3217654974 startingPage "6996" @default.
• W3217654974 abstract "Antimicrobial resistance (AMR) is a complex threat to human health and, to date, it represents a hot topic in drug discovery. The use of non-antibiotic molecules to block resistance mechanisms is a powerful alternative to the identification of new antibiotics. Bacterial efflux pumps exert the early step of AMR development, allowing the bacteria to grow in presence of sub-inhibitory drug concentration and develop more specific resistance mechanisms. Thus, efflux pump inhibitors (EPIs) offer a great opportunity to fight AMR, potentially restoring antibiotic activity. Based on our experience in designing and synthesizing novel EPIs, herein, we retrieved information around quinoline and indole derivatives reported in literature on this topic. Thus, our aim was to collect all data around these promising classes of EPIs in order to delineate a comprehensive structure-activity relationship (SAR) around each core for different microbes. With this review article, we aim to help future research in the field in the discovery of new microbial EPIs with improved activity and a better safety profile." @default.
• W3217654974 created "2021-12-06" @default.
• W3217654974 creator A5001818513 @default.
• W3217654974 creator A5057923752 @default.
• W3217654974 creator A5077113911 @default.
• W3217654974 date "2021-11-19" @default.
• W3217654974 modified "2023-10-05" @default.
• W3217654974 title "Microbial Efflux Pump Inhibitors: A Journey around Quinoline and Indole Derivatives" @default.
• W3217654974 cites W1788555328 @default.
• W3217654974 cites W1844817938 @default.
• W3217654974 cites W1924338650 @default.
• W3217654974 cites W1967457339 @default.
• W3217654974 cites W1968965739 @default.
• W3217654974 cites W1973782344 @default.
• W3217654974 cites W1973843350 @default.
• W3217654974 cites W1978227254 @default.
• W3217654974 cites W1978707497 @default.
• W3217654974 cites W1980655272 @default.
• W3217654974 cites W1981267913 @default.
• W3217654974 cites W1983887734 @default.
• W3217654974 cites W1988149100 @default.
• W3217654974 cites W2000572336 @default.
• W3217654974 cites W2000818650 @default.
• W3217654974 cites W2011917728 @default.
• W3217654974 cites W2012764667 @default.
• W3217654974 cites W2015050900 @default.
• W3217654974 cites W2019062034 @default.
• W3217654974 cites W2022844274 @default.
• W3217654974 cites W2032054300 @default.
• W3217654974 cites W2034401300 @default.
• W3217654974 cites W2042505056 @default.
• W3217654974 cites W2044882852 @default.
• W3217654974 cites W2047721231 @default.
• W3217654974 cites W2049929180 @default.
• W3217654974 cites W2050266703 @default.
• W3217654974 cites W2058762922 @default.
• W3217654974 cites W2059905849 @default.
• W3217654974 cites W2061805336 @default.
• W3217654974 cites W2068017011 @default.
• W3217654974 cites W2069814511 @default.
• W3217654974 cites W2070196678 @default.
• W3217654974 cites W2071490774 @default.
• W3217654974 cites W2072632087 @default.
• W3217654974 cites W2073177849 @default.
• W3217654974 cites W2075693596 @default.
• W3217654974 cites W2079111596 @default.
• W3217654974 cites W2079530723 @default.
• W3217654974 cites W2086941118 @default.
• W3217654974 cites W2093411397 @default.
• W3217654974 cites W2096503523 @default.
• W3217654974 cites W2099095400 @default.
• W3217654974 cites W2101559322 @default.
• W3217654974 cites W2102351560 @default.
• W3217654974 cites W2102906662 @default.
• W3217654974 cites W2103220533 @default.
• W3217654974 cites W2105574566 @default.
• W3217654974 cites W2114625913 @default.
• W3217654974 cites W2115486016 @default.
• W3217654974 cites W2119373372 @default.
• W3217654974 cites W2122432936 @default.
• W3217654974 cites W2124820238 @default.
• W3217654974 cites W2132501554 @default.
• W3217654974 cites W2132793435 @default.
• W3217654974 cites W2134836136 @default.
• W3217654974 cites W2141481816 @default.
• W3217654974 cites W2142400495 @default.
• W3217654974 cites W2142948383 @default.
• W3217654974 cites W2144944670 @default.
• W3217654974 cites W2147807811 @default.
• W3217654974 cites W2149482606 @default.
• W3217654974 cites W2151991784 @default.
• W3217654974 cites W2153763474 @default.
• W3217654974 cites W2154704910 @default.
• W3217654974 cites W2162198167 @default.
• W3217654974 cites W2165306733 @default.
• W3217654974 cites W2175741618 @default.
• W3217654974 cites W2204075485 @default.
• W3217654974 cites W2226757949 @default.
• W3217654974 cites W2228675744 @default.
• W3217654974 cites W2239972278 @default.
• W3217654974 cites W2298100294 @default.
• W3217654974 cites W2328100822 @default.
• W3217654974 cites W2331005861 @default.
• W3217654974 cites W2339059423 @default.
• W3217654974 cites W2343105778 @default.
• W3217654974 cites W2396203445 @default.
• W3217654974 cites W2489596030 @default.
• W3217654974 cites W2527865960 @default.
• W3217654974 cites W2558631499 @default.
• W3217654974 cites W2582772886 @default.
• W3217654974 cites W2597700712 @default.
• W3217654974 cites W2608777297 @default.
• W3217654974 cites W2617364164 @default.
• W3217654974 cites W2622501379 @default.
• W3217654974 cites W2737846718 @default.
• W3217654974 cites W2752848087 @default.
• W3217654974 cites W2755377931 @default.
• W3217654974 cites W2756084051 @default.

• next