Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217697925> ?p ?o ?g. }
- W3217697925 endingPage "118742" @default.
- W3217697925 startingPage "118742" @default.
- W3217697925 abstract "The descending pain modulatory system in humans is commonly investigated using conditioned pain modulation (CPM). Whilst variability in CPM efficiency, i.e., inhibition and facilitation, is normal in healthy subjects, exploring the inter-relationship between brain structure, resting-state functional connectivity (rsFC) and CPM readouts will provide greater insight into the underlying CPM efficiency seen in healthy individuals. Thus, this study combined CPM testing, voxel-based morphometry (VBM) and rsFC to identify the neural correlates of CPM in a cohort of healthy subjects (n =40), displaying pain inhibition (n = 29), facilitation (n = 10) and no CPM effect (n = 1). Clusters identified in the VBM analysis were implemented in the rsFC analysis alongside key constituents of the endogenous pain modulatory system. Greater pain inhibition was related to higher volume of left frontal cortices and stronger rsFC between the motor cortex and periaqueductal grey. Conversely, weaker pain inhibition was related to higher volume of the right frontal cortex - coupled with stronger rsFC to the primary somatosensory cortex, and rsFC between the amygdala and posterior insula. Overall, healthy subjects showed higher volume and stronger rsFC of brain regions involved with descending modulation, while the lateral and medial pain systems were related to greater pain inhibition and facilitation during CPM, respectively. These findings reveal structural alignments and functional interactions between supraspinal areas involved in CPM efficiency. Ultimately understanding these underlying variations and how they may become affected in chronic pain conditions, will advance a more targeted subgrouping in pain patients for future cross-sectional studies investigating endogenous pain modulation." @default.
- W3217697925 created "2021-12-06" @default.
- W3217697925 creator A5009576815 @default.
- W3217697925 creator A5012717312 @default.
- W3217697925 creator A5026159303 @default.
- W3217697925 creator A5032736128 @default.
- W3217697925 creator A5032775119 @default.
- W3217697925 creator A5055781836 @default.
- W3217697925 creator A5061297073 @default.
- W3217697925 creator A5069598374 @default.
- W3217697925 date "2022-02-01" @default.
- W3217697925 modified "2023-10-16" @default.
- W3217697925 title "Descending pain modulatory efficiency in healthy subjects is related to structure and resting connectivity of brain regions" @default.
- W3217697925 cites W1520188707 @default.
- W3217697925 cites W155313802 @default.
- W3217697925 cites W1679990541 @default.
- W3217697925 cites W1735057880 @default.
- W3217697925 cites W1760829075 @default.
- W3217697925 cites W1963771706 @default.
- W3217697925 cites W1966510219 @default.
- W3217697925 cites W1967320240 @default.
- W3217697925 cites W1968369248 @default.
- W3217697925 cites W1969164050 @default.
- W3217697925 cites W1972817980 @default.
- W3217697925 cites W1975161961 @default.
- W3217697925 cites W1981291046 @default.
- W3217697925 cites W1982893910 @default.
- W3217697925 cites W1983183519 @default.
- W3217697925 cites W1983395697 @default.
- W3217697925 cites W1986792164 @default.
- W3217697925 cites W1990134753 @default.
- W3217697925 cites W1995863592 @default.
- W3217697925 cites W2004607543 @default.
- W3217697925 cites W2011131455 @default.
- W3217697925 cites W2015880870 @default.
- W3217697925 cites W2016596542 @default.
- W3217697925 cites W2029045410 @default.
- W3217697925 cites W2029543844 @default.
- W3217697925 cites W2036601288 @default.
- W3217697925 cites W2046836290 @default.
- W3217697925 cites W2048203787 @default.
- W3217697925 cites W2053050435 @default.
- W3217697925 cites W2054014224 @default.
- W3217697925 cites W2059217700 @default.
- W3217697925 cites W2062645254 @default.
- W3217697925 cites W2067346310 @default.
- W3217697925 cites W2068281394 @default.
- W3217697925 cites W2068906079 @default.
- W3217697925 cites W2072181608 @default.
- W3217697925 cites W2079542232 @default.
- W3217697925 cites W2081288257 @default.
- W3217697925 cites W2084892943 @default.
- W3217697925 cites W2087742007 @default.
- W3217697925 cites W2088132969 @default.
- W3217697925 cites W2089082503 @default.
- W3217697925 cites W2107026046 @default.
- W3217697925 cites W2108197576 @default.
- W3217697925 cites W2111464173 @default.
- W3217697925 cites W2113217511 @default.
- W3217697925 cites W2119848633 @default.
- W3217697925 cites W2120013916 @default.
- W3217697925 cites W2120546516 @default.
- W3217697925 cites W2124811217 @default.
- W3217697925 cites W2130010412 @default.
- W3217697925 cites W2135487512 @default.
- W3217697925 cites W2155298532 @default.
- W3217697925 cites W2160662805 @default.
- W3217697925 cites W2165792664 @default.
- W3217697925 cites W2167344375 @default.
- W3217697925 cites W2319720537 @default.
- W3217697925 cites W2331512098 @default.
- W3217697925 cites W2339767472 @default.
- W3217697925 cites W2342066231 @default.
- W3217697925 cites W2399492758 @default.
- W3217697925 cites W2511763988 @default.
- W3217697925 cites W2518532335 @default.
- W3217697925 cites W2551166349 @default.
- W3217697925 cites W2587871103 @default.
- W3217697925 cites W2604834320 @default.
- W3217697925 cites W2775139643 @default.
- W3217697925 cites W2782710572 @default.
- W3217697925 cites W2790266628 @default.
- W3217697925 cites W2793285114 @default.
- W3217697925 cites W2807426801 @default.
- W3217697925 cites W2887089493 @default.
- W3217697925 cites W2889154044 @default.
- W3217697925 cites W2890125899 @default.
- W3217697925 cites W2907047302 @default.
- W3217697925 cites W2922337242 @default.
- W3217697925 cites W2924889935 @default.
- W3217697925 cites W2937324870 @default.
- W3217697925 cites W2945624084 @default.
- W3217697925 cites W2965274893 @default.
- W3217697925 cites W2972864586 @default.
- W3217697925 cites W2998347587 @default.
- W3217697925 doi "https://doi.org/10.1016/j.neuroimage.2021.118742" @default.
- W3217697925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34863962" @default.
- W3217697925 hasPublicationYear "2022" @default.